Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Alessio, Amatu"'
Autor:
Marco Macagno, Valeria Pessei, Noemi Congiusta, Luca Lazzari, Sara Erika Bellomo, Fariha Idrees, Alessandro Cavaliere, Filippo Pietrantonio, Alessandra Raimondi, Eleonora Gusmaroli, Maria Giulia Zampino, Lorenzo Gervaso, Davide Ciardiello, Giuseppe Mondello, Armando Santoro, Nicola Personeni, Emanuela Bonoldi, Maria Costanza Aquilano, Emanuele Valtorta, Salvatore Siena, Andrea Sartore-Bianchi, Alessio Amatu, Erica Francesca Bonazzina, Katia Bruna Bencardino, Guido Serini, Silvia Marsoni, Ludovic Barault, Federica Di Nicolantonio, Federica Maione
Publikováno v:
Diagnostics, Vol 14, Iss 22, p 2467 (2024)
Background: O-6-methylguanine-DNA methyltransferase is responsible for the direct repair of O6-methylguanine lesions induced by alkylating agents, including temozolomide. O-6-methylguanine-DNA methyltransferase promoter hypermethylation is a well-est
Externí odkaz:
https://doaj.org/article/40652073bce64bcb9e506faa61ad1641
Autor:
Gianluca Mauri, Giorgio Patelli, Viviana Gori, Calogero Lauricella, Benedetta Mussolin, Alessio Amatu, Katia Bencardino, Federica Tosi, Erica Bonazzina, Emanuela Bonoldi, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/47b02fe9b6e54c8f96e333df60d08614
Autor:
Gianluca Mauri, Giorgio Patelli, Viviana Gori, Calogero Lauricella, Benedetta Mussolin, Alessio Amatu, Katia Bencardino, Federica Tosi, Erica Bonazzina, Emanuela Bonoldi, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundWe aim to identify the prevalence and the role of the MAP2K1 K57N mutation in predicting resistance to anti-EGFR agents in metastatic colorectal cancer (mCRC) patients.MethodsWe retrospectively reviewed tumor-based next generation sequencin
Externí odkaz:
https://doaj.org/article/9d3f7e85a4bd4497ab7bb8887a40c07d
Autor:
Sara Lonardi, Valter Torri, Fortunato Ciardiello, Andrea Sartore-Bianchi, Salvatore Siena, Silvia Marsoni, Alberto Bardelli, Francesca Bergamo, Cosimo Martino, Elisabetta Fenocchio, Federica Tosi, Silvia Ghezzi, Francesco Leone, Vittorina Zagonel, Andrea Ardizzoni, Alessio Amatu, Katia Bencardino, Emanuele Valtorta, Elena Grassi, Emanuela Bonoldi, Anna Sapino, Angelo Vanzulli, Daniele Regge, Giovanni Cappello, Livio Trusolino
Publikováno v:
ESMO Open, Vol 5, Iss 5 (2020)
Background HER2 is a therapeutic target for metastatic colorectal cancer (mCRC), as demonstrated in the pivotal HERACLES-A (HER2 Amplification for Colo-rectaL cancer Enhanced Stratification) trial with trastuzumab and lapatinib. The aim of HERACLES-B
Externí odkaz:
https://doaj.org/article/83670eb46b49449fab6522df0b311a31
Autor:
Andrea Sartore-Bianchi, Filippo Pietrantonio, Sara Lonardi, Benedetta Mussolin, Francesco Rua, Giovanni Crisafulli, Alice Bartolini, Elisabetta Fenocchio, Alessio Amatu, Paolo Manca, Francesca Bergamo, Federica Tosi, Gianluca Mauri, Margherita Ambrosini, Francesca Daniel, Valter Torri, Angelo Vanzulli, Daniele Regge, Giovanni Cappello, Caterina Marchiò, Enrico Berrino, Anna Sapino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Publikováno v:
Nature Medicine
Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies are approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC), but the emergence of resistance mutations restricts their efficacy. We previously showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78476c66d1c7f63b72ea85b3eb4cbfe1
https://doi.org/10.1038/s41591-022-01886-0
https://doi.org/10.1038/s41591-022-01886-0
Autor:
Alessio Amatu, Marta Schirripa, Federica Tosi, Sara Lonardi, Katia Bencardino, Erica Bonazzina, Laura Palmeri, Damiano Alfio Patanè, Elio Gregory Pizzutilo, Benedetta Mussolin, Francesca Bergamo, Giulia Alberti, Rossana Intini, Letizia Procaccio, Marco Arese, Silvia Marsoni, Michele Nichelatti, Vittorina Zagonel, Salvatore Siena, Alberto Bardelli, Fotios Loupakis, Federica Di Nicolantonio, Andrea Sartore-Bianchi, Ludovic Barault
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Regorafenib improves progression free survival (PFS) in a subset of metastatic colorectal cancer (mCRC) patients, although no biomarkers of efficacy are available. Circulating methylated DNA (cmDNA) assessed by a five-gene panel was previ
Externí odkaz:
https://doaj.org/article/03adbb2e3faf4c54b1f03312367d97e5
Autor:
Salvatore Siena, Vasileios Askoxylakis, Glenn Dranoff, Marc R. Pelletier, Lang Ho Lee, Lori A. Iaconis, Sarah M. Choi, Heidi A. Schoenfeld, Kulandayan Subramanian, Ping C. Mahling, Susan E. Cellitti, Alex Cortez, Yasutoshi Kuboki, Jaffer A. Ajani, Alessio Amatu, Toshihiko Doi, Sae-Won Han, Filip Janku
Immune-stimulator antibody conjugates (ISAC) combining tumor-targeting monoclonal antibodies with immunostimulatory agents allow targeted delivery of immune activators into tumors. NJH395 is a novel, first-in-class ISAC comprising a Toll‐like recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7971b7d07116fc0c53b6de7673a36ee9
https://doi.org/10.1158/2326-6066.c.6551021.v1
https://doi.org/10.1158/2326-6066.c.6551021.v1
Autor:
Salvatore Siena, Vasileios Askoxylakis, Glenn Dranoff, Marc R. Pelletier, Lang Ho Lee, Lori A. Iaconis, Sarah M. Choi, Heidi A. Schoenfeld, Kulandayan Subramanian, Ping C. Mahling, Susan E. Cellitti, Alex Cortez, Yasutoshi Kuboki, Jaffer A. Ajani, Alessio Amatu, Toshihiko Doi, Sae-Won Han, Filip Janku
Supplementary Figure from Preclinical Characterization and Phase I Study of an Anti–HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704176b41c46a7157ecea1d47d7de480
https://doi.org/10.1158/2326-6066.22545746.v1
https://doi.org/10.1158/2326-6066.22545746.v1
Autor:
Alberto Bardelli, Salvatore Siena, Silvia Marsoni, Federica Di Nicolantonio, Giovanni Germano, Emanuela Bonoldi, Emanuele Valtorta, Federica Morano, Laura Idotta, Federica Tosi, Pietro Paolo Vitiello, Valeria Pessei, Maria Giulia Zampino, Nicola Personeni, Paolo Battuello, Gianluca Mauri, Paolo Luraghi, Alice Bartolini, Andrea Cassingena, Ludovic Barault, Marco Macagno, Alessio Amatu, Filippo Pietrantonio, Luca Lazzari, Andrea Sartore-Bianchi, Giovanni Crisafulli
Supplementary Figure from Temozolomide Treatment Alters Mismatch Repair and Boosts Mutational Burden in Tumor and Blood of Colorectal Cancer Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c88c3aa4671914cfc6cc7801152c57
https://doi.org/10.1158/2159-8290.22541308
https://doi.org/10.1158/2159-8290.22541308
Autor:
Salvatore Siena, Vasileios Askoxylakis, Glenn Dranoff, Marc R. Pelletier, Lang Ho Lee, Lori A. Iaconis, Sarah M. Choi, Heidi A. Schoenfeld, Kulandayan Subramanian, Ping C. Mahling, Susan E. Cellitti, Alex Cortez, Yasutoshi Kuboki, Jaffer A. Ajani, Alessio Amatu, Toshihiko Doi, Sae-Won Han, Filip Janku
Supplementary Data from Preclinical Characterization and Phase I Study of an Anti–HER2-TLR7 Immune-Stimulator Antibody Conjugate in Patients with HER2+ Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5f94745c1462cb05163a0a0fdf5af8
https://doi.org/10.1158/2326-6066.22545749.v1
https://doi.org/10.1158/2326-6066.22545749.v1