Výsledky vyhledávání - "Alessia Tacito"

Akademický článek

Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing

Autor: Raffaele Ciampi, Cristina Romei, Teresa Ramone, Alessandro Prete, Alessia Tacito, Virginia Cappagli, Valeria Bottici, David Viola, Liborio Torregrossa, Clara Ugolini, Fulvio Basolo, Rossella Elisei

Publikováno v: iScience, Vol 20, Iss , Pp 324-336 (2019)

Summary: Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest serie

Externí odkaz: https://doaj.org/article/c067dd680ca24053bb7e48f472207fe3

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Akademický článek

A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion

Autor: Carlotta Giani, Teresa Ramone, Cristina Romei, Raffaele Ciampi, Alessia Tacito, Laura Valerio, Laura Agate, Clara Ugolini, Michele Marinò, Fulvio Basolo, Alessandro Franchi, Simona Borsari, Angela Michelucci, Cesare Selli, Gabriele Materazzi, Filomena Cetani, Rossella Elisei

Publikováno v: Case Reports in Endocrinology, Vol 2020 (2020)

Background. Multiple endocrine neoplasia type 2 (MEN2) is a hereditary cancer syndrome caused by RET proto-oncogene mutation. Two different clinical variants of MEN2 are known (MEN2A and MEN2B): medullary thyroid carcinoma (MTC) almost always present

Externí odkaz: https://doaj.org/article/735b841494db4930aef14e21dfdc9d20

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Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing

Autor: Teresa Ramone, Alessandro Prete, Raffaele Ciampi, Rossella Elisei, Liborio Torregrossa, Alessia Tacito, Virginia Cappagli, Cristina Romei, Clara Ugolini, Valeria Bottici, David Viola, Fulvio Basolo

Publikováno v: iScience
iScience, Vol 20, Iss, Pp 324-336 (2019)

Summary Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a8820a2f1f3be993cf1ca9801448c9
https://doi.org/10.1016/j.isci.2019.09.030

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A New MEN2 Syndrome with Clinical Features of Both MEN2A and MEN2B Associated with a New RET Germline Deletion

Autor: Raffaele Ciampi, Cristina Romei, Clara Ugolini, Michele Marinò, Cesare Selli, Angela Michelucci, Teresa Ramone, Rossella Elisei, Alessandro Franchi, Gabriele Materazzi, Laura Agate, Carlotta Giani, Simona Borsari, Laura Valerio, Filomena Cetani, Fulvio Basolo, Alessia Tacito

Publikováno v: Case Reports in Endocrinology
Case Reports in Endocrinology, Vol 2020 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b39a6f499bf7bff07e8c3a49a120852
http://europepmc.org/articles/PMC7411486

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MON-490 Calcitonin-Based Thyroidectomy Is a Safe Approach in Patients with Germline RET Mutation and Permits to Delay Surgery in Children

Autor: Luciana Puleo, Laura Valerio, David Viola, Valeria Bottici, Loredana Lorusso, Laura Agate, Alessia Tacito, Teresa Ramone, Cristina Romei, Alessandro Prete, Rossella Elisei, Carlotta Giani, Eleonora Molinaro, Virginia Cappagli, Antonio Matrone

Publikováno v: Journal of the Endocrine Society

Introduction: Medullary thyroid cancer (MTC) arises from C cells secreting calcitonin. In familial MTC cases, a germline RET mutation is discovered in 98% of cases. Nowadays, an early diagnosis and radical surgery are the only curative approach. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714b36b5dfffc12bf3fe4f78f439116a
http://hdl.handle.net/11568/1065386

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Medullary thyroid cancer treated with vandetanib: predictors of longer and durable response

Autor: Rossella Elisei, David Viola, Alessia Tacito, Virginia Cappagli, Antonio Matrone, Raffaele Ciampi, Teresa Ramone, Valeria Bottici, Paolo Piaggi, Cristina Romei, Laura Valerio, Eleonora Molinaro, Laura Agate

Vandetanib is an important treatment option for advanced metastatic medullary thyroid cancer. The aims of this study were to evaluate the predictors of both a longer response to vandetanib and the outcome. Medical records of 79 medullary thyroid canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4d60c57ca00f2539e9ce101234470d
https://hdl.handle.net/11568/1015758

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RET mutation heterogeneity in primary advanced medullary thyroid cancers and their metastases

Autor: Raffaele Ciampi, Paolo Vitti, Liborio Torregrossa, Fulvio Basolo, Francesca Casella, Gabriele Materazzi, Cristina Romei, Alessia Tacito, Clara Ugolini, Rossella Elisei

Publikováno v: Oncotarget

// Cristina Romei 1 , Raffaele Ciampi 1 , Francesca Casella 1 , Alessia Tacito 1 , Liborio Torregrossa 2 , Clara Ugolini 2 , Fulvio Basolo 2 , Gabriele Materazzi 2 , Paolo Vitti 1 and Rossella Elisei 1 1 Endocrine Unit, Department of Clinical and Exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688ba6d4f286441e6e616259b029c61e
https://doi.org/10.18632/oncotarget.23986

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Twenty-Five Years Experience on RET Genetic Screening on Hereditary MTC: An Update on The Prevalence of Germline RET Mutations

Autor: Cristina Campopiano, Rossella Elisei, Eleonora Molinaro, Raffaele Ciampi, Teresa Ramone, Valeria Bottici, Alessandro Prete, Laura Valerio, Cristina Romei, David Viola, Carlotta Giani, Virginia Cappagli, Antonio Matrone, Laura Agate, Loredana Lorusso, Alessia Tacito

Publikováno v: Genes, Vol 10, Iss 9, p 698 (2019)
Genes
Volume 10
Issue 9

Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie the development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were to evaluate the prevalence of germline RET mutations in a large series of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::907bf09cc18ae61903935b2f2b0938f6
https://www.mdpi.com/2073-4425/10/9/698

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