Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Alessia Ruggieri"'
Autor:
Leonie Küchenhoff, Pascal Lukas, Camila Metz-Zumaran, Paul Rothhaar, Alessia Ruggieri, Volker Lohmann, Thomas Höfer, Megan L. Stanifer, Steeve Boulant, Soheil Rastgou Talemi, Frederik Graw
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Local cell densities and positioning within cellular monolayers and stratified epithelia have important implications for cell interactions and the functionality of various biological processes. To analyze the relationship between cell locali
Externí odkaz:
https://doaj.org/article/145f2434d0ac4799ac1864a9f488f8b2
Autor:
Vera Magg, Alessandro Manetto, Katja Kopp, Chia Ching Wu, Mohsen Naghizadeh, Doris Lindner, Lucy Eke, Julia Welsch, Stefan M. Kallenberger, Johanna Schott, Volker Haucke, Nicolas Locker, Georg Stoecklin, Alessia Ruggieri
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114069- (2024)
Summary: The integrated stress response (ISR) is a key cellular signaling pathway activated by environmental alterations that represses protein synthesis to restore homeostasis. To prevent sustained damage, the ISR is counteracted by the upregulation
Externí odkaz:
https://doaj.org/article/57ac933c39544e17ab8442346bf13c6f
Synthetic virions reveal fatty acid-coupled adaptive immunogenicity of SARS-CoV-2 spike glycoprotein
Autor:
Oskar Staufer, Kapil Gupta, Jochen Estebano Hernandez Bücher, Fabian Kohler, Christian Sigl, Gunjita Singh, Kate Vasileiou, Ana Yagüe Relimpio, Meline Macher, Sebastian Fabritz, Hendrik Dietz, Elisabetta Ada Cavalcanti Adam, Christiane Schaffitzel, Alessia Ruggieri, Ilia Platzman, Imre Berger, Joachim P. Spatz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Staufer et al. provide a protocol for preparation of synthetic minimal virions (MiniV) of SARS-CoV-2, mimicking viral structure and allowing for precise investigation of receptor binding mechanism. They find that the highly conserved free fatty acid
Externí odkaz:
https://doaj.org/article/6ea4469e431243f488c82533fd47c2d8
Autor:
Carolin Zitzmann, Bianca Schmid, Alessia Ruggieri, Alan S. Perelson, Marco Binder, Ralf Bartenschlager, Lars Kaderali
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Dengue virus (DV) is a positive-strand RNA virus of the Flavivirus genus. It is one of the most prevalent mosquito-borne viruses, infecting globally 390 million individuals per year. The clinical spectrum of DV infection ranges from an asymptomatic c
Externí odkaz:
https://doaj.org/article/941a60b06fbe457c85c262d64d24f21f
Autor:
Michèle Brocard, Valentina Iadevaia, Philipp Klein, Belinda Hall, Glenys Lewis, Jia Lu, James Burke, Margaret M Willcocks, Roy Parker, Ian G Goodfellow, Alessia Ruggieri, Nicolas Locker
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008250 (2020)
Viral infections impose major stress on the host cell. In response, stress pathways can rapidly deploy defence mechanisms by shutting off the protein synthesis machinery and triggering the accumulation of mRNAs into stress granules to limit the use o
Externí odkaz:
https://doaj.org/article/434c34f4ccb84ee9bf9ac09e310feadd
Autor:
Philipp Schult, Hanna Roth, Rebecca L. Adams, Caroline Mas, Lionel Imbert, Christian Orlik, Alessia Ruggieri, Anna M. Pyle, Volker Lohmann
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The liver-specific microRNA-122 is an essential proviral host factor of Hepatitis C virus replication. Here the authors show that microRNA-122 functions as an RNA chaperone that guides the formation of a functional internal ribosome entry site by pre
Externí odkaz:
https://doaj.org/article/0fd247a540674475b845c754d80d8b1f
Autor:
Mirko Cortese, Sarah Goellner, Eliana Gisela Acosta, Christopher John Neufeldt, Olga Oleksiuk, Marko Lampe, Uta Haselmann, Charlotta Funaya, Nicole Schieber, Paolo Ronchi, Martin Schorb, Priit Pruunsild, Yannick Schwab, Laurent Chatel-Chaix, Alessia Ruggieri, Ralf Bartenschlager
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2113-2123 (2017)
Summary: A global concern has emerged with the pandemic spread of Zika virus (ZIKV) infections that can cause severe neurological symptoms in adults and newborns. ZIKV is a positive-strand RNA virus replicating in virus-induced membranous replication
Externí odkaz:
https://doaj.org/article/2c72f910e44f4593a9b7414b5b35b1da
Autor:
Ji-Young Lee, Mirko Cortese, Uta Haselmann, Keisuke Tabata, Inés Romero-Brey, Charlotta Funaya, Nicole L. Schieber, Yu Qiang, Marie Bartenschlager, Stephanie Kallis, Christian Ritter, Karl Rohr, Yannick Schwab, Alessia Ruggieri, Ralf Bartenschlager
Publikováno v:
Cell Reports, Vol 27, Iss 12, Pp 3602-3617.e5 (2019)
Summary: The hepatitis C virus (HCV) is a major cause of chronic liver disease, affecting around 71 million people worldwide. Viral RNA replication occurs in a membranous compartment composed of double-membrane vesicles (DMVs), whereas virus particle
Externí odkaz:
https://doaj.org/article/b47d6362fb914877b4724dfa3547b780
Autor:
Mirko Cortese, Anil Kumar, Petr Matula, Lars Kaderali, Pietro Scaturro, Holger Erfle, Eliana Gisela Acosta, Sandra Buehler, Alessia Ruggieri, Laurent Chatel-Chaix, Karl Rohr, Ralf Bartenschlager
Publikováno v:
Cell Reports, Vol 27, Iss 9, Pp 2579-2592.e6 (2019)
Summary: Dengue virus (DENV) is a human arboviral pathogen accounting for 390 million infections every year. The available vaccine has limited efficacy, and DENV-specific drugs have not been generated. To better understand DENV-host cell interaction,
Externí odkaz:
https://doaj.org/article/dd8a461af3af48fe99228315757f6314
Publikováno v:
Viruses, Vol 12, Iss 9, p 984 (2020)
Cells have evolved highly specialized sentinels that detect viral infection and elicit an antiviral response. Among these, the stress-sensing protein kinase R, which is activated by double-stranded RNA, mediates suppression of the host translation ma
Externí odkaz:
https://doaj.org/article/e61ee5c6ba11429e8ae2eb3d241eeae2