Výsledky vyhledávání - "Alessia Ricupito"

Data from Modulators of Arginine Metabolism Do Not Impact on Peripheral T-Cell Tolerance and Disease Progression in a Model of Spontaneous Prostate Cancer

Autor: Matteo Bellone, Massimo Freschi, Luca Generoso, Matteo Grioni, Elena Jachetti, Alessia Ricupito, Giusy Capuano, Nicolò Rigamonti

Purpose: Chronic inflammation, recruitment of myeloid-derived cells, and perturbation of the arginine metabolism have been all proposed as mechanisms favoring prostate carcinogenesis and tumor immunoescape. Objective of this study was to evaluate whe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e37f2bfb781fbba714766606d34902
https://doi.org/10.1158/1078-0432.c.6520163.v1

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Supplemental Figures 1 - 7 from Booster Vaccinations against Cancer Are Critical in Prophylactic but Detrimental in Therapeutic Settings

Autor: Matteo Bellone, Anna Mondino, Renato Longhi, Rodrigo Hess Michelini, Arianna Calcinotto, Matteo Grioni, Alessia Ricupito

Supplemental Figures 1 - 7 PDF 2666K, Supplemental Figure 1. Priming with DC-Tag induces a long-lasting antigenspecific immune response. Supplemental Figure 2. Boosting increases the absolute number of rapidly responding Ag-specific CD8+ splenocytes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c603cb76e7451d64986f4f109e8f9c
https://doi.org/10.1158/0008-5472.22397055.v1

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Booster Vaccinations against Cancer Are Critical in Prophylactic but Detrimental in Therapeutic Settings

Autor: Matteo Bellone, Anna Mondino, Alessia Ricupito, Arianna Calcinotto, Renato Longhi, Rodrigo Hess Michelini, Matteo Grioni

Publikováno v: Cancer research (Chic. Ill.) 73 (2013): 3545–3554. doi:10.1158/0008-5472.CAN-12-2449
info:cnr-pdr/source/autori:Ricupito, Alessia; Grioni, Matteo; Calcinotto, Arianna; Michelini, Rodrigo Hess; Longhi, Renato; Mondino, Anna; Bellone, Matteo/titolo:Booster Vaccinations against Cancer Are Critical in Prophylactic but Detrimental in Therapeutic Settings/doi:10.1158%2F0008-5472.CAN-12-2449/rivista:Cancer research (Chic. Ill.)/anno:2013/pagina_da:3545/pagina_a:3554/intervallo_pagine:3545–3554/volume:73

Although cancer vaccines are in the clinic, several issues remain to be addressed to increase vaccine efficacy. In particular, whether how and how frequently a patient should be boosted remains to be defined. Here, we have assessed the ability of den

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58af8a5e125baa35a910b00ee12a86e0
https://doi.org/10.1158/0008-5472.can-12-2449

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Modulation of Microenvironment Acidity Reverses Anergy in Human and Murine Tumor-Infiltrating T Lymphocytes

Autor: Elena Jachetti, Luca Generoso, Mario Santinami, Licia Rivoltini, Manuela Iero, Arianna Calcinotto, Angelo De Milito, Monica Rossetti, Giorgio Parmiani, Alessia Ricupito, Matteo Grioni, Paola Filipazzi, Rossella Canese, Agata Cova, Stefano Fais, Veronica Huber, Matteo Bellone, Martina Borghi

Publikováno v: Cancer Research. 72:2746-2756

Stimulating the effector functions of tumor-infiltrating T lymphocytes (TIL) in primary and metastatic tumors could improve active and adoptive T-cell therapies for cancer. Abnormal glycolysis, high lactic acid production, proton accumulation, and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3d86987e49bde26248e4c842df802e
https://doi.org/10.1158/0008-5472.can-11-1272

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Induction of T-cell memory by a dendritic cell vaccine: a computational model

Autor: Francesco Topputo, Matteo Bellone, Alessia Ricupito, Marzio Pennisi, Francesco Pappalardo

Publikováno v: Bioinformatics (Oxford, England). 30(13)

Motivation: Although results from phase III clinical trials substantially support the use of prophylactic and therapeutic vaccines against cancer, what has yet to be defined is how many and how frequent boosts are needed to sustain a long-lasting and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ddaf5faa3cdae8d9e767193624823a
https://pubmed.ncbi.nlm.nih.gov/24603984

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Modulators of arginine metabolism do not impact on peripheral T-cell tolerance and disease progression in a model of spontaneous prostate cancer

Autor: Massimo Freschi, Matteo Grioni, Luca Generoso, Nicolò Rigamonti, Elena Jachetti, Alessia Ricupito, Giusy Capuano, Matteo Bellone

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 17(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2be2f280e89b9663b514d337bd1225
https://pubmed.ncbi.nlm.nih.gov/21248302

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Concurrent allorecognition has a limited impact on posttransplant vaccination

Autor: Elizabeth Simpson, Matteo Bellone, Veronica Basso, Anna Mondino, Teresa Manzo, Jian-Guo Chai, Alessia Ricupito, Rodrigo Hess Michelini

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 186(3)

Transplantation of allogeneic hematopoietic stem cells with or without immunocompetent lymphocytes has proved a successful strategy in the treatment of hematological malignancies. We have recently shown that this approach can also cure mouse prostate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6780671bb3de2a149186c57c6817268
https://pubmed.ncbi.nlm.nih.gov/21209285

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