Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Alessia Lenoci"'
Autor:
Alessia Lenoci, Maria E. Ourailidou, Clemens Zwergel, Dante Rotili, Antonello Mai, Frank J. Dekker
Publikováno v:
Bioorganic & Medicinal Chemistry, 25(3), 847-856. PERGAMON-ELSEVIER SCIENCE LTD
The implications of lysine-specific demethylase-1 (LSD1) in tumorigenesis have urged scientists to develop diagnostic tools in order to explore the function of this enzyme. In this work, we present our efforts on the development of tranylcypromine (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc6385cc4af7e29bcb34a432f57c504
https://doi.org/10.1016/j.bmc.2016.11.043
https://doi.org/10.1016/j.bmc.2016.11.043
Autor:
Kim Krist, Frank J. Dekker, Niek G. J. Leus, Alessia Lenoci, Antonello Mai, Maria E. Ourailidou
Publikováno v:
MedChemCommun, 7(11), 2184-2190. ROYAL SOC CHEMISTRY
Histone deacetylases (HDACs) have been used as pharmacological targets for the treatment of various diseases. Some non-selective HDAC inhibitors (HDACi) have been clinically-used as therapeutic agents for treatment of hematological cancers but their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859ce3d6bb16a9a762f1abf985982770
https://doi.org/10.1039/c6md00375c
https://doi.org/10.1039/c6md00375c
Autor:
Antonello Mai, Daniela Secci, Patrizia Filetici, Lucia Altucci, Melissa D'Ascenzio, Celeste De Monte, Angela Nebbioso, Veronica Rodriguez, Alessia Lenoci, Marco Miceli, Dante Rotili, Simone Carradori
Publikováno v:
European journal of medicinal chemistry 80 (2014): 569–578. doi:10.1016/j.ejmech.2014.04.042
info:cnr-pdr/source/autori:Carradori, Simone; Rotili, Dante; De Monte, Celeste; Lenoci, Alessia; D'Ascenzio, Melissa; Rodriguez, Veronica; Filetici, Patrizia; Miceli, Marco; Nebbioso, Angela; Altucci, Lucia; Secci, Daniela; Mai, Antonello/titolo:Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies/doi:10.1016%2Fj.ejmech.2014.04.042/rivista:European journal of medicinal chemistry/anno:2014/pagina_da:569/pagina_a:578/intervallo_pagine:569–578/volume:80
info:cnr-pdr/source/autori:Carradori, Simone; Rotili, Dante; De Monte, Celeste; Lenoci, Alessia; D'Ascenzio, Melissa; Rodriguez, Veronica; Filetici, Patrizia; Miceli, Marco; Nebbioso, Angela; Altucci, Lucia; Secci, Daniela; Mai, Antonello/titolo:Evaluation of a large library of (thiazol-2-yl)hydrazones and analogues as histone acetyltransferase inhibitors: Enzyme and cellular studies/doi:10.1016%2Fj.ejmech.2014.04.042/rivista:European journal of medicinal chemistry/anno:2014/pagina_da:569/pagina_a:578/intervallo_pagine:569–578/volume:80
Recently we described some (thiazol-2-yl)hydrazones as antiprotozoal, antifungal and anti-MAO agents as well as Gcn5 HAT inhibitors. Among these last compounds, CPTH2 and CPTH6 showed HAT inhibition in cells and broad anticancer properties. With the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74331fe3b270bdcfa9a77c8bb6a1f8d6
https://doi.org/10.1016/j.ejmech.2014.04.042
https://doi.org/10.1016/j.ejmech.2014.04.042
Autor:
Rosaria Benedetti, Simone Carradori, Gianluca Sbardella, Alessia Lenoci, Stefano Tomassi, Lucia Altucci, Ettore Novellino, Veronica Rodriguez, Antonello Mai, Patrizia Filetici, Daniela Secci, Sabrina Castellano, Mariarosaria Conte, Dante Rotili
Publikováno v:
ChemMedChem; Vol 9
ChemMedChem
9 (2014): 542–548. doi:10.1002/cmdc.201300536
info:cnr-pdr/source/autori:Lenoci, Alessia; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Rodriguez, Veronica; Carradori, Simone; Secci, Daniela; Castellano, Sabrina; Sbardella, Gianluca; Filetici, Patrizia; Novellino, Ettore; Altucci, Lucia; Rotili, Dante; Mai, Antonello/titolo:Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells/doi:10.1002%2Fcmdc.201300536/rivista:ChemMedChem (Print)/anno:2014/pagina_da:542/pagina_a:548/intervallo_pagine:542–548/volume:9
ChemMedChem
9 (2014): 542–548. doi:10.1002/cmdc.201300536
info:cnr-pdr/source/autori:Lenoci, Alessia; Tomassi, Stefano; Conte, Mariarosaria; Benedetti, Rosaria; Rodriguez, Veronica; Carradori, Simone; Secci, Daniela; Castellano, Sabrina; Sbardella, Gianluca; Filetici, Patrizia; Novellino, Ettore; Altucci, Lucia; Rotili, Dante; Mai, Antonello/titolo:Quinoline-Based p300 Histone Acetyltransferase Inhibitors with Pro-apoptotic Activity in Human Leukemia U937 Cells/doi:10.1002%2Fcmdc.201300536/rivista:ChemMedChem (Print)/anno:2014/pagina_da:542/pagina_a:548/intervallo_pagine:542–548/volume:9
Chemical manipulations performed on 2-methyl-3-carbethoxyquinoline (1), a histone acetyltransferase inhibitor previously identified by our research group and active at the sub-millimolar/millimolar level, led to compounds bearing higher alkyl groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d0c1205b687286f4be043530b4beb1
http://hdl.handle.net/11386/4273853
http://hdl.handle.net/11386/4273853
Autor:
Marco Miceli, Antonello Mai, Gerald Brosch, Alessia Lenoci, Donatella Del Bufalo, Angela Nebbioso, Lucia Altucci, Giulio Dondio, Daniela Trisciuoglio, Sergio Valente, Teresa De Luca, Donatella Labella, Chiara Bigogno
Publikováno v:
Journal of medicinal chemistry 57 (2014): 6259–6265. doi:10.1021/jm500303u
info:cnr-pdr/source/autori:Valente, Sergio; Trisciuoglio, Daniela; De Luca, Teresa; Nebbioso, Angela; Labella, Donatella; Lenoci, Alessia; Bigogno, Chiara; Dondio, Giulio; Miceli, Marco; Brosch, Gerald; Del Bufalo, Donatella; Altucci, Lucia; Mai, Antonello/titolo:1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells/doi:10.1021%2Fjm500303u/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:6259/pagina_a:6265/intervallo_pagine:6259–6265/volume:57
info:cnr-pdr/source/autori:Valente, Sergio; Trisciuoglio, Daniela; De Luca, Teresa; Nebbioso, Angela; Labella, Donatella; Lenoci, Alessia; Bigogno, Chiara; Dondio, Giulio; Miceli, Marco; Brosch, Gerald; Del Bufalo, Donatella; Altucci, Lucia; Mai, Antonello/titolo:1,3,4-Oxadiazole-Containing Histone Deacetylase Inhibitors: Anticancer Activities in Cancer Cells/doi:10.1021%2Fjm500303u/rivista:Journal of medicinal chemistry/anno:2014/pagina_da:6259/pagina_a:6265/intervallo_pagine:6259–6265/volume:57
We describe 1,3,4-oxadiazole-containing hydroxamates (2) and 2-aminoanilides (3) as histone deacetylase inhibitors. Among them, 2t, 2x, and 3i were the most potent and selective against HDAC1. In U937 leukemia cells, 2t was more potent than SAHA in i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef6fa0a6448bf020104ae8557502636
https://publications.cnr.it/doc/287245
https://publications.cnr.it/doc/287245
Autor:
Maija Lahtela-Kakkonen, Antti Poso, Covadonga Huidobro, Angela Nebbioso, Giorgia Botta, Mario F. Fraga, Antonello Mai, Riccardo Pezzi, Alessia Lenoci, Domenico Tarantino, Ruggero De Maria, Paolo Mellini, Manel Esteller, Dante Rotili, Lucia Altucci, Paola Gallinari, Chantal Paolini, Christian Steinkühler, Ester Lara
Publikováno v:
Journal of Medicinal Chemistry; Vol 55
Journal of medicinal chemistry 55(24) (2012): 10937–10947. doi:10.1021/jm3011614
info:cnr-pdr/source/autori:Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A./titolo:Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells/doi:10.1021%2Fjm3011614/rivista:Journal of medicinal chemistry/anno:2012/pagina_da:10937/pagina_a:10947/intervallo_pagine:10937–10947/volume:55(24)
Journal of medicinal chemistry 55(24) (2012): 10937–10947. doi:10.1021/jm3011614
info:cnr-pdr/source/autori:Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A./titolo:Discovery of Salermide-Related Sirtuin Inhibitors: Binding Mode Studies and Antiproliferative Effects in Cancer Cells Including Cancer Stem Cells/doi:10.1021%2Fjm3011614/rivista:Journal of medicinal chemistry/anno:2012/pagina_da:10937/pagina_a:10947/intervallo_pagine:10937–10947/volume:55(24)
Chemical changes performed on 1a (sirtinol) led to a series of SIRT1/2 inhibitors, in some cases more potent than 1a mainly against SIRT1. Tested in human leukemia U937 cells, the benzamide and anilide derivatives 1b, 1c, 2b, and 2c as well as the 4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390e9203d2b332b0f5304b1579d37160
https://pubmed.ncbi.nlm.nih.gov/23189967
https://pubmed.ncbi.nlm.nih.gov/23189967
Autor:
Kapoor, Garima1 (AUTHOR), Bhutani, Rubina2 (AUTHOR), Pathak, Dharam Pal3 (AUTHOR), Chauhan, Garima3 (AUTHOR), Kant, Ravi4 (AUTHOR), Grover, Parul1 (AUTHOR), Nagarajan, Kandasamy1 (AUTHOR), Siddiqui, Shadab Ahmad1 (AUTHOR)
Publikováno v:
Polycyclic Aromatic Compounds. 2022, Vol. 42 Issue 7, p4183-4215. 33p.
Autor:
Luisi, Grazia1 (AUTHOR) gluisi@unich.it, Mollica, Adriano1 (AUTHOR), Carradori, Simone1 (AUTHOR), Lenoci, Alessia2 (AUTHOR), De Luca, Anastasia3 (AUTHOR), Caccuri, Anna Maria3,4 (AUTHOR) caccuri@uniroma2.it
Publikováno v:
Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2016, Vol. 31 Issue 6, p924-930. 7p.
Publikováno v:
MedChemComm; Nov2016, Vol. 7 Issue 11, p2037-2043, 7p
Autor:
Ourailidou, Maria E., Leus, Niek G. J., Krist, Kim, Lenoci, Alessia, Mai, Antonello, Dekker, Frank J.
Publikováno v:
MedChemComm; Nov2016, Vol. 7 Issue 11, p2184-2190, 7p