Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alessia Deglincerti"'
Autor:
Xu-Qiao Chen, Carlos A. Barrero, Rodrigo Vasquez-Del Carpio, E. Premkumar Reddy, Chiara Fecchio, Salim Merali, Alessia Deglincerti, Cheng Fang, Jack Rogers, Maria L. Maccecchini
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2109 (2021)
Posiphen tartrate (Posiphen) is an orally available small molecule that targets a conserved regulatory element in the mRNAs of amyloid precursor protein (APP) and α-synuclein (αSYN) and inhibits their translation. APP and αSYN can cause neurodegen
Externí odkaz:
https://doaj.org/article/89386ce687ad4c2ebd214da12cad2f41
Autor:
Albert Ruzo, Ismail Ismailoglu, Melissa Popowski, Tomomi Haremaki, Gist F Croft, Alessia Deglincerti, Ali H Brivanlou
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127687 (2015)
Huntington's disease (HD) is a devastating neurological disorder that is caused by an expansion of the poly-Q tract in exon 1 of the Huntingtin gene (HTT). HTT is an evolutionarily conserved and ubiquitously expressed protein that has been linked to
Externí odkaz:
https://doaj.org/article/b806f1ebb3894fd1b68967ca19ebda2e
Autor:
Alessia Deglincerti, Samie R. Jaffrey
Publikováno v:
Open Biology, Vol 2, Iss 6 (2012)
Summary Much of our knowledge on the roles of intra-axonal translation derives from the characterization of a small number of individual mRNAs that were found to be localized in axons. However, two recent studies, using large-scale approaches to prov
Externí odkaz:
https://doaj.org/article/f21d7fb55fbc4bbd898f83afadf87600
Publikováno v:
Developmental Biology. 408:305-315
Huntington's Disease (HD) is a neurodegenerative disorder that results from the abnormal expansion of poly-glutamine (polyQ) repeats in the Huntingtin (HTT) gene. Although HTT has been linked to a variety of cellular events, it is still not clear wha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::710ddbf42f946e0d4d4bb338cd510b78
https://doi.org/10.1016/j.ydbio.2015.07.013
https://doi.org/10.1016/j.ydbio.2015.07.013
Local translation is critical for diverse aspects of neuronal function, including mediating responses of elongating axons to guidance cues and other signaling molecules. A major determinant of the protein synthetic capacity of axons and growth cones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d3a7f08320a95a743c5a1f35e11ccf
https://europepmc.org/articles/PMC5798196/
https://europepmc.org/articles/PMC5798196/
Autor:
Anna Yoney, Eric D. Siggia, Aryeh Warmflash, Ali H. Brivanlou, Fred Etoc, Alessia Deglincerti, Jakob J. Metzger, Mijo Simunovic, Iain Martyn, Albert Ruzo, M Cecilia Guerra
Fate allocation in the gastrulating embryo is spatially organized as cells differentiate into specialized cell types depending on their positions with respect to the body axes. There is a need for in vitro protocols that allow the study of spatial or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c9eeba4f319e97b8e4937332cf3a65
https://europepmc.org/articles/PMC5821517/
https://europepmc.org/articles/PMC5821517/
Publikováno v:
Protocol Exchange.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fc708bd42ef44b0142a950b318d4fc6
https://doi.org/10.1038/protex.2016.022
https://doi.org/10.1038/protex.2016.022
Autor:
Eric D. Siggia, Magdalena Zernicka-Goetz, Ali H Brivanlou, Alessia Deglincerti, Gist F. Croft, Lauren N. Pietila
Implantation of the blastocyst is a developmental milestone in mammalian embryonic development. At this time, a coordinated program of lineage diversification, cell-fate specification, and morphogenetic movements establishes the generation of extra-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c3213798fe85e49d7bd207abfc17789
https://resolver.caltech.edu/CaltechAUTHORS:20190405-170314964
https://resolver.caltech.edu/CaltechAUTHORS:20190405-170314964
Publikováno v:
Current topics in developmental biology. 116
The developing embryo is a remarkable example of self-organization, where functional units are created in a complex spatiotemporal choreography. Recently, human embryonic stem cells (ESCs) have been used to recapitulate in vitro the self-organization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598214c724163c720afba5411b7ca6ce
https://pubmed.ncbi.nlm.nih.gov/26970615
https://pubmed.ncbi.nlm.nih.gov/26970615
Publikováno v:
Nature cell biology
During development, axon growth rates are precisely regulated to provide temporal control over pathfinding. The precise temporal regulation of axonal growth is a key step in the formation of functional synapses and the proper patterning of the nervou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a3bf948748ca3065e0ccec9b019c47
https://doi.org/10.1038/ncb1916
https://doi.org/10.1038/ncb1916