One- and Two-Electron Oxidations of β-Amyloid25-35 by Carbonate Radical Anion (CO3•−) and Peroxymonocarbonate (HCO4−): Role of Sulfur in Radical Reactions and Peptide Aggregation

Autor: Antonio Francioso, Alessia Baseggio Conrado, Carla Blarzino, Cesira Foppoli, Elita Montanari, Simone Dinarelli, Alessandra Giorgi, Luciana Mosca, Mario Fontana

Publikováno v: Molecules, Vol 25, Iss 4, p 961 (2020)

The β-amyloid (Aβ) peptide plays a key role in the pathogenesis of Alzheimer’s disease. The methionine (Met) residue at position 35 in Aβ C-terminal domain is critical for neurotoxicity, aggregation, and free radical formation initiated by the p

Externí odkaz: https://doaj.org/article/053bb1eaee4a49bab0b1b9bac629d940

Pheomelanin Effect on UVB Radiation-Induced Oxidation/Nitration of l-Tyrosine

Autor: Alessia Mariano, Irene Bigioni, Anna Scotto d’Abusco, Alessia Baseggio Conrado, Simonetta Maina, Antonio Francioso, Luciana Mosca, Mario Fontana

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 1; Pages: 267
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 23, Iss 267, p 267 (2022)

Pheomelanin is a natural yellow-reddish sulfur-containing pigment derived from tyrosinase-catalyzed oxidation of tyrosine in presence of cysteine. Generally, the formation of melanin pigments is a protective response against the damaging effects of U

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab29625dde0adb2c4b13ed813d6a9d8d

Role of Hypotaurine in Protection against UVA-Induced Damage in Keratinocytes

Autor: Sally H. Ibbotson, Sergio Fanelli, Victoria A. McGuire, Alessia Baseggio Conrado

Publikováno v: Photochemistry and photobiologyReferences. 97(2)

Photoageing and skin cancer are major causes of morbidity and are a high cost to society. Interest in the development of photoprotective agents for inclusion in topical cosmetic and sunscreen products is profound. Recently, amino acids with a sulfini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9abea43b8b93a91ade32c9514ed0f02
https://pubmed.ncbi.nlm.nih.gov/32959397

One- and two-electron oxidations of β-amyloid25-35 by carbonate radical anion (CO3•-) and peroxymonocarbonate (HCO4-): role of sulfur in radical reactions and peptide aggregation

Autor: Simone Dinarelli, Alessandra Giorgi, Luciana Mosca, Elita Montanari, Cesira Foppoli, Antonio Francioso, Mario Fontana, Alessia Baseggio Conrado, Carla Blarzino

Publikováno v: Molecules
Volume 25
Issue 4
Molecules, Vol 25, Iss 4, p 961 (2020)

The &beta
amyloid (A&beta
) peptide plays a key role in the pathogenesis of Alzheimer&rsquo
s disease. The methionine (Met) residue at position 35 in A&beta
C-terminal domain is critical for neurotoxicity, aggregation, and free ra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e402f14db6bdaa3f11e6dad7034dcee4
https://hdl.handle.net/11575/125523

Thiotaurine:from chemical and biological properties to role in H2S signaling

Autor: Luciana Mosca, Elisabetta Capuozzo, Alessia Baseggio Conrado, Antonio Francioso, Mario Fontana

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9789811380228

In the last decade thiotaurine, 2-aminoethane thiosulfonate, has been investigated as an inflammatory modulating agent as a result of its ability to release hydrogen sulfide (H2S) known to play regulatory roles in inflammation. Thiotaurine can be inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94275b1b45be238596776b5effaa9493
https://hdl.handle.net/11575/125562