Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Alessia Amore"'
Autor:
David S. Hewings, Johanna Heideker, Taylur P. Ma, Andrew P. AhYoung, Farid El Oualid, Alessia Amore, Gregory T. Costakes, Daniel Kirchhofer, Bradley Brasher, Thomas Pillow, Nataliya Popovych, Till Maurer, Carsten Schwerdtfeger, William F. Forrest, Kebing Yu, John Flygare, Matthew Bogyo, Ingrid E. Wertz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Deubiquitinases are proteases that cleave after the C-terminus of ubiquitin to hydrolyze ubiquitin chains and cleave ubiquitin from substrates. Here the authors describe a reactive-site-centric chemoproteomics approach to studying deubiquitinase acti
Externí odkaz:
https://doaj.org/article/a36fd9ead45149f0b851c7d214b80597
Autor:
Sebastian Kiehstaller, George H. Hutchins, Alessia Amore, Alan Gerber, Mohamed Ibrahim, Sven Hennig, Saskia Neubacher, Tom N. Grossmann
Publikováno v:
Kiehstaller, S, Hutchins, G H, Amore, A, Gerber, A, Ibrahim, M, Hennig, S, Neubacher, S & Grossmann, T N 2023, ' Bicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions ', Bioconjugate chemistry, vol. 34, no. 6, pp. 1114-1121 . https://doi.org/10.1021/acs.bioconjchem.3c00151
Bioconjugate chemistry. American Chemical Society
Bioconjugate chemistry. American Chemical Society
Enzymes are of central importance to many biotechnological and biomedical applications. However, for many potential applications, the required conditions impede enzyme folding and therefore function. The enzyme Sortase A is a transpeptidase that is w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::900073b38c8c7146288c8df4ea14297a
https://hdl.handle.net/1871.1/ce68c81f-f931-4ebd-93ed-e2d4861cf034
https://hdl.handle.net/1871.1/ce68c81f-f931-4ebd-93ed-e2d4861cf034
Autor:
Dharjath S. Hameed, Aysegul Sapmaz, Lindsey Burggraaff, Alessia Amore, Cornelis J. Slingerland, Gerard J. P. Westen, Huib Ovaa
Publikováno v:
Angewandte Chemie. 131:14619-14624
Autor:
Aysegul Sapmaz, Huib Ovaa, Lindsey Burggraaff, Gerard J. P. van Westen, Alessia Amore, Dharjath S. Hameed, Cornelis J Slingerland
Publikováno v:
Angewandte Chemie International Edition, 58(41), 14477-14482
Angewandte Chemie International Edition
Angewandte Chemie International Edition
Deubiquitinases (DUBs) are a family of enzymes that regulate the ubiquitin signaling cascade by removing ubiquitin from specific proteins in response to distinct signals. DUBs that belong to the metalloprotease family (metalloDUBs) contain Zn2+ in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f212b0cb1511031e277ee8dfa75b1703
https://hdl.handle.net/1887/82724
https://hdl.handle.net/1887/82724
Autor:
Rieuwert Hoppes, Evelyn Koekoek, Ton N. Schumacher, Alessia Amore, Kim Wals, Boris Rodenko, Huib Ovaa, Mireille Toebes
Publikováno v:
Chembiochem
Incorporation of cleavable linkers into peptides and proteins is of particular value in the study of biological processes. Here we describe the synthesis of a cleavable linker that is hypersensitive to oxidative cleavage as the result of the periodat
Autor:
Alessia Amore, Marcello Allegretti, Alberto Dolce, Andrea Aramini, Manolo R. Sablone, Gianluca Bianchini, Plinio Perrone, Michela Fani
Publikováno v:
Tetrahedron. 65:2015-2021
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key
Autor:
Gijs A. van der Marel, Alessia Amore, Arne van der Gen, Michael van der Hoeven, Reynier A. Tromp, Johannes Brussee, Mark Overhand
Publikováno v:
Tetrahedron: Asymmetry. 12:1109-1112
A chemoenzymatic and stereoselective synthesis of Fmoc-protected (2 S ,3 S )-2-hydroxy-3-amino acids from 2-furaldehyde is described as well as their application, without prior hydroxyl protection, in the solid-phase synthesis of a novel completely
Autor:
Gianluca Bianchini, Alessia Amore, Manolo R. Sablone, Alberto Dolce, Plinio Perrone, Michela Fani, Andrea Aramini, Marcello Allegretti
Publikováno v:
ChemInform. 40
A novel one-pot two-step procedure has been developed to synthesize highly substituted 2-arylpropionic and arylacetic acids, by treatment with aqueous HI, from cyanohydrins. The hydrogenolytic reduction of α-hydroxy-2-arylpropionic acids was the key
Autor:
Ton N. Schumacher, Rieuwert Hoppes, Boris Rodenko, Huib Ovaa, Evelien Koekoek, Mireille Toebes, Alessia Amore, Kim Wals
Publikováno v:
Molecular Immunology. 51:6-7
Publikováno v:
The Journal of Organic Chemistry
Journal of Organic Chemistry, 85(3), 1476-1483. American Chemical Society
Neubacher, S, Saya, J M, Amore, A & Grossmann, T N 2020, ' In Situ Cyclization of Proteins (INCYPRO) : Cross-Link Derivatization Modulates Protein Stability ', Journal of Organic Chemistry, vol. 85, no. 3, pp. 1476-1483 . https://doi.org/10.1021/acs.joc.9b02490
Journal of Organic Chemistry, 85(3), 1476-1483. American Chemical Society
Neubacher, S, Saya, J M, Amore, A & Grossmann, T N 2020, ' In Situ Cyclization of Proteins (INCYPRO) : Cross-Link Derivatization Modulates Protein Stability ', Journal of Organic Chemistry, vol. 85, no. 3, pp. 1476-1483 . https://doi.org/10.1021/acs.joc.9b02490
Protein macrocyclization represents a very efficient strategy to increase the stability of protein tertiary structures. Here, we describe a panel of novel C3-symmetric tris-electrophilic agents and their use for the cyclization of proteins. These ele