Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alessia, Golluscio"'
Autor:
Alessia Golluscio, Jodene Eldstrom, Jessica J Jowais, Marta Elena Perez, Kevin Peter Cunningham, Alicia De La Cruz, Xiaoan Wu, Valentina Corradi, D Peter Tieleman, David Fedida, H Peter Larsson
Publikováno v:
eLife, Vol 13 (2024)
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolo
Externí odkaz:
https://doaj.org/article/3b70b86ed7a5417386c6095c41baafa2
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: Numerous pathogenic variants in KCNB1, which encodes the voltage-gated potassium channel, KV2.1, are linked to developmental and epileptic encephalopathies and associated with loss-of-function, -regulation, and -expression of the channel.
Externí odkaz:
https://doaj.org/article/48d5df39250d4195bac5fee05793b7ee
Publikováno v:
Frontiers in pharmacology. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fa2fb7fdaeefd7ed672a302c99a4946
https://pubmed.ncbi.nlm.nih.gov/36618935
https://pubmed.ncbi.nlm.nih.gov/36618935
Publikováno v:
Biophysical Journal. 122:386a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7418bfd740c3f92bc194d661402191ae
https://doi.org/10.1016/j.bpj.2022.11.2115
https://doi.org/10.1016/j.bpj.2022.11.2115
Publikováno v:
Handbook of experimental pharmacology. 267
In this review, we consider the pharmacology of potassium channels from the perspective of these channels as therapeutic targets. Firstly, we describe the three main families of potassium channels in humans and disease states where they are implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::857f38afe575f394bf55227bd66933fa
https://pubmed.ncbi.nlm.nih.gov/34195873
https://pubmed.ncbi.nlm.nih.gov/34195873
Publikováno v:
Pharmacology of Potassium Channels ISBN: 9783030840518
In this review, we consider the pharmacology of potassium channels from the perspective of these channels as therapeutic targets. Firstly, we describe the three main families of potassium channels in humans and disease states where they are implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b34e20725563aacabc7a79e7b2e0a26
https://doi.org/10.1007/164_2021_502
https://doi.org/10.1007/164_2021_502
Autor:
Nikita Gamper, KeWei Wang
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate g