Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Alessia, Finotti"'
Autor:
Maria Rita Gamberini, Cristina Zuccato, Matteo Zurlo, Lucia Carmela Cosenza, Alessia Finotti, Roberto Gambari
Publikováno v:
Hematology Reports, Vol 15, Iss 3, Pp 432-439 (2023)
The β-thalassemias are a group of monogenic hereditary hematological disorders caused by deletions and/or mutations of the β-globin gene, leading to low or absent production of adult hemoglobin (HbA). For β-thalassemia, sirolimus has been under cl
Externí odkaz:
https://doaj.org/article/cb0e102625de42d687cf73b2b04b12dd
Autor:
Roberto Gambari, Alessia Finotti
Publikováno v:
Cells, Vol 13, Iss 11, p 918 (2024)
The β-thalassemias are inherited genetic disorders affecting the hematopoietic system. In β-thalassemias, more than 350 mutations of the adult β-globin gene cause the low or absent production of adult hemoglobin (HbA). A clinical parameter affecti
Externí odkaz:
https://doaj.org/article/560e4740bc164af1a922e0ccab9427af
Autor:
Valentino Bezzerri, Valentina Gentili, Martina Api, Alessia Finotti, Chiara Papi, Anna Tamanini, Christian Boni, Elena Baldisseri, Debora Olioso, Martina Duca, Erika Tedesco, Sara Leo, Monica Borgatti, Sonia Volpi, Paolo Pinton, Giulio Cabrini, Roberto Gambari, Francesco Blasi, Giuseppe Lippi, Alessandro Rimessi, Roberta Rizzo, Marco Cipolli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Patients with cystic fibrosis are not reporting particularly sever outcomes upon SARS-CoV-2 infection. Here, the authors demonstrate decreased ACE2 levels is cystic fibrosis airway epithelia associated with impaired viral entry and replication.
Externí odkaz:
https://doaj.org/article/469ec52418bc4d8eb0ef6499688e03e5
Autor:
Alessia Finotti, Roberto Gambari
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Genome editing (GE) is one of the most efficient and useful molecular approaches to correct the effects of gene mutations in hereditary monogenetic diseases, including β-thalassemia. CRISPR-Cas9 gene editing has been proposed for effective correctio
Externí odkaz:
https://doaj.org/article/a77ecaa7ed004c42b0a7b484823e7b18
Autor:
Cristina Zuccato, Lucia Carmela Cosenza, Chiara Tupini, Alessia Finotti, Gianni Sacchetti, Daniele Simoni, Roberto Gambari, Ilaria Lampronti
Publikováno v:
Molecules, Vol 29, Iss 1, p 8 (2023)
Induction of fetal hemoglobin (HbF) is highly beneficial for patients carrying β-thalassemia, and novel HbF inducers are highly needed. Here, we describe a new class of promising HbF inducers characterized by an isoxazole chemical skeleton and obtai
Externí odkaz:
https://doaj.org/article/e1abf3e761f14c6eaf81ed7b2c14153a
Autor:
Roberto Gambari, Cristina Zuccato, Lucia Carmela Cosenza, Matteo Zurlo, Jessica Gasparello, Alessia Finotti, Maria Rita Gamberini, Marco Prosdocimi
Publikováno v:
Biology, Vol 12, Iss 9, p 1202 (2023)
In this review article, we present the fascinating story of rapamycin (sirolimus), a drug able to induce γ-globin gene expression and increased production of fetal hemoglobin (HbF) in erythroid cells, including primary erythroid precursor cells (ErP
Externí odkaz:
https://doaj.org/article/9b516fe69a7b4406aa1fd7419ea2538d
Autor:
Jessica Gasparello, Chiara Papi, Matteo Zurlo, Stefano Volpi, Roberto Gambari, Roberto Corradini, Alessandro Casnati, Francesco Sansone, Alessia Finotti
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2121 (2023)
One of the most appealing approaches for regulating gene expression, named the “microRNA therapeutic” method, is based on the regulation of the activity of microRNAs (miRNAs), the intracellular levels of which are dysregulated in many diseases, i
Externí odkaz:
https://doaj.org/article/61237ea7126749d5877537ce7838f30a
Autor:
Alessia Finotti, Ilaria Lampronti, Roberto Gambari, Cristina Zuccato, Marco Prosdocimi, Monica Borgatti, Lucia Carmela Cosenza
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
Drug repositioning and the relevance of orphan drug designation for β-thalassemia is reviewed. Drug repositioning and similar terms ('drug repurposing', 'drug reprofiling', 'drug redirecting', ‘drug rescue’, ‘drug re-tasking’ and/or 'drug re
Externí odkaz:
https://doaj.org/article/39076482c34641b6a1f45b12ca0a19af
Autor:
Lucia Carmela Cosenza, Jessica Gasparello, Nicola Romanini, Matteo Zurlo, Cristina Zuccato, Roberto Gambari, Alessia Finotti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 507-523 (2021)
Gene editing by the CRISPR-Cas9 nuclease system technology can be considered among the most promising strategies to correct hereditary mutations in a variety of monogenic diseases. In this paper, we present for the first time the correction, by CRISP
Externí odkaz:
https://doaj.org/article/c341716d7de144c7b048cb6790ed1339
Autor:
Chiara Tupini, Matteo Zurlo, Jessica Gasparello, Irene Lodi, Alessia Finotti, Thomas Scattolin, Fabiano Visentin, Roberto Gambari, Ilaria Lampronti
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1332 (2023)
Combined treatments employing lower concentrations of different drugs are used and studied to develop new and more effective anticancer therapeutic approaches. The combination therapy could be of great interest in the controlling of cancer. Regarding
Externí odkaz:
https://doaj.org/article/c8172d0bf8a8415a81a2c3d8e42afc6b