Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alessandro Zarpellon"'
Autor:
Sachiko Kanaji, Yosuke Morodomi, Hartmut Weiler, Alessandro Zarpellon, Robert R. Montgomery, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Type 2B von Willebrand disease (VWD) is caused by gain-of-function mutations in von Willebrand factor (VWF). Increased VWF affinity for GPIba results in loss of high molecular weight multimers and enhanced platelet clearance, both contributing to the
Externí odkaz:
https://doaj.org/article/5292c9accfd547d095570b33387baee9
Autor:
Yosuke Morodomi, Sachiko Kanaji, Brian M. Sullivan, Alessandro Zarpellon, Jennifer N. Orje, Eric Won, Ryan Shapiro, Xiang-Lei Yang, Wolfram Ruf, Paul Schimmel, Zaverio M. Ruggeri, Taisuke Kanaji
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(48)
Platelets play a role not only in hemostasis and thrombosis, but also in inflammation and innate immunity. We previously reported that an activated form of tyrosyl-tRNA synthetase (YRS ACT ) has an extratranslational activity that enhances megakaryop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c5d3c3d4822deaeac39b6b7e1f0b6a
https://pubmed.ncbi.nlm.nih.gov/36409883
https://pubmed.ncbi.nlm.nih.gov/36409883
Autor:
Meredith O'Keeffe, Rachel L. Sielski, Juan Carlos de la Torre, Patrick Skog, Armen Zeitjian, Brian R. Lawson, Deli Huang, Benjamin F. Cravatt, Kent G. Osborn, Markus Damme, David Nemazee, Therese C. Thinnes, Farnaz Kargaran, Hubertus Hochrein, Christoph Huber, Alessandro Zarpellon, Annica Mårtensson, Hayley S. Chong, John R. Teijaro, Phoebe Kimm, Amanda L. Gavin, Megan Briggs, Luc Teyton, Tanya R. Blane, Sebastian R. Schulz, Virginie Tardif, Ee Shan Pang
Publikováno v:
Nature immunology
The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linked the gene encoding phospholipase D3 (PLD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a9bdbaccba333a5fbd414c0688719c
https://doi.org/10.1038/s41590-018-0179-y
https://doi.org/10.1038/s41590-018-0179-y
Autor:
Megan J. Welch, Zaverio M. Ruggeri, Lucy E Horton, Roberto Aiolfi, Brian M. Sullivan, Brian C. Ware, Alessandro Zarpellon, Michael B. A. Oldstone
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(33)
Understanding of T cell exhaustion and successful therapy to restore T cell function was first described using Clone (Cl) 13 variant selected from the lymphocytic choriomeningitis virus (LCMV) Armstrong (ARM) 53b parental strain. T cell exhaustion pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8d1f78a09f607e3138dbe2b5327248
https://pubmed.ncbi.nlm.nih.gov/30061383
https://pubmed.ncbi.nlm.nih.gov/30061383
Autor:
Cherie T. Ng, Megan J. Welch, Brian M. Sullivan, Rosana Gonzalez-Quintial, Michael B. A. Oldstone, Alessandro Zarpellon, John R. Teijaro, Kevin B. Walsh, Argyrios N. Theofilopoulos, Zaverio M. Ruggeri, Anthony H. Nguyen, Juan Carlos de la Torre, Roberto Baccala
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8925-8930
The outcome of a viral infection reflects the balance between virus virulence and host susceptibility. The clone 13 (Cl13) variant of lymphocytic choriomeningitis virus--a prototype of Old World arenaviruses closely related to Lassa fever virus--elic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658b62fa586c4cd046177cdb32d9a77c
https://doi.org/10.1073/pnas.1408148111
https://doi.org/10.1073/pnas.1408148111
Autor:
Alessandro Zarpellon, Hui Ouyang, Zaverio M. Ruggeri, Prithu Sundd, Ekaterina K. Koltsova, Klaus Ley, Antonella Zampolli, Zbigniew Mikulski
Publikováno v:
Thrombosis and Haemostasis. 112:1252-1263
SummaryThe pathogenesis of atherosclerosis involves the interplay of haematopoietic, stromal and endothelial cells. Platelet interactions with endothelium and leukocytes are pivotal for atherosclerosis promotion. Glycoprotein (GP) Ibα is the ligand-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b4860ed12285123638836455af186
https://doi.org/10.1160/th14-02-0130
https://doi.org/10.1160/th14-02-0130
Autor:
Zaverio M. Ruggeri, Alona Merkulova, Jennifer J. Hofmann, Alessandro Zarpellon, David J. Shields, Eric A. Murphy, Sara M. Weis, Lea Scheppke, Tatiana V. Byzova, David A. Cheresh, M. Luisa Iruela-Arispe
Publikováno v:
Blood. 119:2149-2158
Vascular development and angiogenesis initially depend on endothelial tip cell invasion, which is followed by a series of maturation steps, including lumen formation and recruitment of perivascular cells. Notch ligands expressed on the endothelium an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29158cde26864e70f48815fbb8db701
https://doi.org/10.1182/blood-2011-04-348706
https://doi.org/10.1182/blood-2011-04-348706
Autor:
James D. McFadyen, Shaun P. Jackson, Yuping Yuan, Mehran Ghasemzadeh, Zane Kaplan, Zaverio M. Ruggeri, Imala Alwis, Alessandro Zarpellon, Simone M. Schoenwaelder
Publikováno v:
Nature communications. 6
Thrombin is a central regulator of leukocyte recruitment and inflammation at sites of vascular injury, a function thought to involve primarily endothelial PAR cleavage. Here we demonstrate the existence of a distinct leukocyte-trafficking mechanism r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a060dc926de096a39641091cd1f1d9
https://pubmed.ncbi.nlm.nih.gov/26204458
https://pubmed.ncbi.nlm.nih.gov/26204458
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
The pathogenesis of atherosclerosis involves the interplay of blood, stromal and endothelial cells; platelet interactions with vascular endothelium and leukocytes promote atherosclerosis. Glycoprotein (GP) Iba is the ligand-binding subunit of the pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d698a947b371c127b4dde88847722ffd
https://doi.org/10.1161/atvb.34.suppl_1.58
https://doi.org/10.1161/atvb.34.suppl_1.58
Autor:
Hui Zhou, Heyu Ni, Xi Lei, Zaverio M. Ruggeri, Fang Qian, Yiming Wang, Zhengyu Xu, Jing Liu, Karen Vanhoorelbeke, Benjamin X Li, Alexandra H. Marshall, Guohui Zhang, Xiangrong Dai, Chaofan Liang, Yan Hou, Alessandro Zarpellon, Zhongqiang Yang, Adili Reheman, Jie Shen, Yanan Zhao
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Platelet adhesion and aggregation are critical for hemostasis and atherothrombosis. Interaction between the GPIb complex and VWF initiates platelet adhesion and contributes to complete vessel occlusion, particularly at sites of stenosis. However, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a38d139437da147dc3472c7784682e4
https://doi.org/10.1161/atvb.34.suppl_1.499
https://doi.org/10.1161/atvb.34.suppl_1.499