Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Alessandro Torgovnick"'
Autor:
Gero Knittel, Tim Rehkämper, Darya Korovkina, Paul Liedgens, Christian Fritz, Alessandro Torgovnick, Yussor Al-Baldawi, Mona Al-Maarri, Yupeng Cun, Oleg Fedorchenko, Arina Riabinska, Filippo Beleggia, Phuong-Hien Nguyen, F. Thomas Wunderlich, Monika Ortmann, Manuel Montesinos-Rongen, Eugen Tausch, Stephan Stilgenbauer, Lukas P. Frenzel, Marco Herling, Carmen Herling, Jasmin Bahlo, Michael Hallek, Martin Peifer, Reinhard Buettner, Thorsten Persigehl, H. Christian Reinhardt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
ATM and TP53 mutations are associated with poor prognosis in chronic lymphocytic leukaemia (CLL). Here the authors generate mouse models of Tp53- and Atm-defective CLL mimicking the high-risk form of human disease and show that Atm-deficient CLL is s
Externí odkaz:
https://doaj.org/article/93c8b6674f2b4c01a38589c9951b35af
Autor:
Alessandro Torgovnick, Jan Michel Heger, Vasiliki Liaki, Jörg Isensee, Anna Schmitt, Gero Knittel, Arina Riabinska, Filippo Beleggia, Lucie Laurien, Uschi Leeser, Christian Jüngst, Florian Siedek, Wenzel Vogel, Niklas Klümper, Hendrik Nolte, Maike Wittersheim, Lars Tharun, Roberta Castiglione, Marcus Krüger, Astrid Schauss, Sven Perner, Manolis Pasparakis, Reinhard Büttner, Thorsten Persigehl, Tim Hucho, Grit Sophie Herter-Sprie, Björn Schumacher, Hans Christian Reinhardt
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Externí odkaz:
https://doaj.org/article/662c648938254acfa54677dfa23bd2fb
Autor:
Holger Grüll, Anna Schmitt, Filippo Beleggia, Gero Knittel, Andreas Rosenwald, Andrea Merseburg, Arndt Borkhardt, Wolfram Klapper, Gita Mall, Ron D. Jachimowicz, Hans Christian Reinhardt, Arlette Paillard, Janica L Wiederstein, Christian Fritz, Wilhelm Wößmann, Aenne Geyer, Monika Ortmann, Lukas P. Frenzel, Maike Wittersheim, Frank Wunderlich, Thorsten Persigehl, Stefan Burdach, Alessandro Torgovnick, Sven Perner, Claudia M. Wunderlich, Reinhard Büttner, Martin-Leo Hansmann, Daria Lehrmann, Olaf Utermöhlen, Marcus Krüger, Arina Riabinska, Martin Peifer, Carola Heneweer
Publikováno v:
Leukemia 34(3), 771-786 (2019). doi:10.1038/s41375-019-0618-2
Leukemia
Leukemia
The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5f9b8cfc6eed839d7085cfa21c65da
https://pub.dzne.de/record/145055
https://pub.dzne.de/record/145055
Autor:
Filippo Beleggia, Hendrik Nolte, Niklas Klümper, Vasiliki Liaki, Hans Christian Reinhardt, Lars Tharun, Alessandro Torgovnick, Florian Siedek, Sven Perner, Jörg Isensee, Jan Michel Heger, Lucie Laurien, Gero Knittel, Maike Wittersheim, Reinhard Büttner, Anna Schmitt, Manolis Pasparakis, Arina Riabinska, Uschi Leeser, Wenzel Vogel, Christian Jüngst, Roberta Castiglione, Thorsten Persigehl, Grit Herter-Sprie, Tim Hucho, Astrid Schauss, Björn Schumacher, Marcus Krüger
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1027-1039.e6 (2018)
Summary: Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to gen
Autor:
Thomas E. Johnson, Sebastian Honnen, Henok Kassahun, Björn Schumacher, Natascia Ventura, Anjumara Shaik, Silvia Maglioni, Shane L. Rea, Alfonso Schiavi, Hans Christian Reinhardt, Hilde Nilsen, Alessandro Torgovnick
Publikováno v:
EMBO reports. 19
Interventions that promote healthy aging are typically associated with increased stress resistance. Paradoxically, reducing the activity of core biological processes such as mitochondrial or insulin metabolism promotes the expression of adaptive resp
Autor:
Alessandro, Torgovnick, Jan Michel, Heger, Vasiliki, Liaki, Jörg, Isensee, Anna, Schmitt, Gero, Knittel, Arina, Riabinska, Filippo, Beleggia, Lucie, Laurien, Uschi, Leeser, Christian, Jüngst, Florian, Siedek, Wenzel, Vogel, Niklas, Klümper, Hendrik, Nolte, Maike, Wittersheim, Lars, Tharun, Roberta, Castiglione, Marcus, Krüger, Astrid, Schauss, Sven, Perner, Manolis, Pasparakis, Reinhard, Büttner, Thorsten, Persigehl, Tim, Hucho, Grit Sophie, Herter-Sprie, Björn, Schumacher, Hans Christian, Reinhardt
Publikováno v:
Cell reports. 25(4)
Cdkn1a, which encodes p21, functions as a major route for p53-mediated cell-cycle arrest. However, the consequence of Cdkn1a gene dosage on tumor suppression has not been systematically investigated. Here, we employed BAC transgenesis to generate a C
Autor:
Alessandro Torgovnick, Stephan Stilgenbauer, Arina Riabinska, Yupeng Cun, Filippo Beleggia, Manuel Montesinos-Rongen, Eugen Tausch, Marco Herling, Carmen D. Herling, Yussor Al-Baldawi, Martin Peifer, Gero Knittel, Christian Fritz, Reinhard Buettner, Paul Liedgens, Darya Korovkina, Phuong-Hien Nguyen, Mona Al-Maarri, Oleg Fedorchenko, Michael Hallek, F. Thomas Wunderlich, Monika Ortmann, Jasmin Bahlo, Lukas P. Frenzel, Thorsten Persigehl, H. Christian Reinhardt, Tim Rehkämper
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Chronic lymphocytic leukemia (CLL) remains an incurable disease. Two recurrent cytogenetic aberrations, namely del(17p), affecting TP53, and del(11q), affecting ATM, are associated with resistance against genotoxic chemotherapy (del17p) and poor outc
Publikováno v:
Zeitschrift für Gerontologie und Geriatrie. 46:623-628
The microscopic worm Caenorhabditis elegans (C. elegans) is one of the most prominent animal models for aging studies. This is underscored by the fact that most of the genes and interventions that modulate the aging process, such as the insulin/IGF p
Autor:
Jessica M. Lindvall, Alessandro Torgovnick, Bryce J. Marquis, Thomas R. Bürglin, Natascia Ventura, Olli Matilainen, Johan Henriksson, Carina I. Holmberg, Hilde Nilsen, Bryant C. Nelson, Henok Kassahun, Silvia Maglioni, Eshrat Babaie, Bernd Thiede, Pawel Jaruga, Katarzyna D. Arczewska, Gisele G. Tomazella
Publikováno v:
Nucleic Acids Research
Transcription-blocking oxidative DNA damage is believed to contribute to aging and to underlie activation of oxidative stress responses and down-regulation of insulin-like signaling (ILS) in Nucleotide Excision Repair (NER) deficient mice. Here, we p
Autor:
Natascia Ventura, Thomas E. Johnson, Alfonso Schiavi, Roberto Testi, Alessandro Torgovnick, Shane L. Rea
Publikováno v:
Aging Cell. 8:380-393
Mitochondrial pathologies underlie a number of life-shortening diseases in humans. In the nematode Caenorhabditis elegans, severely reduced expression of mitochondrial proteins involved in electron transport chain-mediated energy production also lead