Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Alessandro T. Caputo"'
Autor:
Kevin P. Guay, Roberta Ibba, J.L. Kiappes, Snežana Vasiljević, Francesco Bonì, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Juliane Brun, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Matteo De Rosa, Mario Milani, Carlos P. Modenutti, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107919- (2023)
Summary: Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promi
Externí odkaz:
https://doaj.org/article/65e937022caf475ebc2513beca012f73
Autor:
Alessandro T. Caputo, Roberta Ibba, James D. Le Cornu, Benoit Darlot, Mario Hensen, Colette B. Lipp, Gabriele Marcianò, Snežana Vasiljević, Nicole Zitzmann, Pietro Roversi
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
None of the current data processing pipelines for X-ray crystallography fragment-based lead discovery (FBLD) consults all the information available when deciding on the lattice and symmetry (i.e., the polymorph) of each soaked crystal. Often, X-ray c
Externí odkaz:
https://doaj.org/article/4ca222cc6f924253ab4d7ed74f052108
Autor:
Alessandro T. Caputo, Oliver M. Eder, Hana Bereznakova, Heleen Pothuis, Albert Ardevol, Janet Newman, Stewart Nuttall, Thomas S. Peat, Timothy E. Adams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Puromycin and the Streptomyces alboniger-derived puromycin N-acetyltransferase (PAC) enzyme form a commonly used system for selecting stably transfected cultured cells. The crystal structure of PAC has been solved using X-ray crystallography
Externí odkaz:
https://doaj.org/article/e3fd4beb677e4374affab46d03fe0260
Autor:
Rebecca L. Ambrose, Aaron M. Brice, Alessandro T. Caputo, Marina R. Alexander, Leon Tribolet, Yu Chih Liu, Timothy E. Adams, Andrew G.D. Bean, Cameron R. Stewart
Publikováno v:
Heliyon, Vol 6, Iss 6, Pp e04115- (2020)
Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously
Externí odkaz:
https://doaj.org/article/96a360ba07674e3a941ab5386b2c681f
Autor:
Yvonne Joho, Vanessa Vongsouthi, Matthew A. Spence, Jennifer Ton, Chloe Gomez, Li Lynn Tan, Joe A. Kaczmarski, Alessandro T. Caputo, Santana Royan, Colin J. Jackson, Albert Ardevol
Publikováno v:
Biochemistry. 62:437-450
Autor:
F. Hafna Ahmed, Alessandro T. Caputo, Nigel G. French, Thomas S. Peat, Jason Whitfield, Andrew C. Warden, Janet Newman, Colin Scott
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:599-612
Anthozoan chromoproteins are highly pigmented, diversely coloured and readily produced in recombinant expression systems. While they are a versatile and powerful building block in synthetic biology for applications such as biosensor development, they
Autor:
Oliver M. Eder, Stewart D. Nuttall, Albert Ardevol, Thomas S. Peat, Janet Newman, Alessandro T. Caputo, Heleen Pothuis, Timothy E. Adams, Hana Bereznakova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Puromycin and the Streptomyces alboniger-derived puromycin N-acetyltransferase (PAC) enzyme form a commonly used system for selecting stably transfected cultured cells. The crystal structure of PAC has been solved using X-ray crystallography, reveali
Autor:
Kevin P. Guay, Roberta Ibba, JL Kiappes, Maria De Benedictis, Ilaria Zeni, James D. Le Cornu, Mario Hensen, Anu V. Chandran, Anastassia L. Kantsadi, Alessandro T. Caputo, Juan I. Blanco Capurro, Yusupha Bayo, Johan C. Hill, Kieran Hudson, Andrea Lia, Snežana Vasiljević, Carlos P. Modenutti, Stephen G. Withers, Marcelo Martí, Emiliano Biasini, Angelo Santino, Daniel N. Hebert, Nicole Zitzmann, Pietro Roversi
Publikováno v:
SSRN Electronic Journal.
The Endoplasmic Reticulum (ER) glycoprotein folding Quality Control (ERQC) machinery aids folding of glycoproteins in the ER. Misfolded glycoprotein recognition and ER-retention is mediated by the ERQC checkpoint enzyme, the 170 kDa UDP-Glucose glyco
Autor:
Timothy E. Adams, Alessandro T. Caputo, Cameron R. Stewart, Leon Tribolet, Yu Chih Liu, Marina R. Alexander, Andrew G. D. Bean, Aaron M. Brice, Rebecca L. Ambrose
Publikováno v:
Heliyon, Vol 6, Iss 6, Pp e04115-(2020)
Heliyon
Heliyon
Regulation of type-I interferon (IFN) production is essential to the balance between antimicrobial defence and autoimmune disorders. The human protein-coding gene ILRUN (inflammation and lipid regulator with UBA-like and NBR1-like domains, previously
Autor:
J. L. Kiappes, Alessandro T. Caputo, Raymond A. Dwek, Pietro Roversi, Nicholas Sheets, Kelly L. Warfield, Anthony M. Treston, Matthew Duchars, Nicole Zitzmann, Johan C. Hill, Dale L. Barnard, Dominic S. Alonzi, Sujan Shresta, Julia E. Biggins
Publikováno v:
Journal of medicinal chemistry. 63(8)
Influenza and dengue viruses present a growing global threat to public health. Both viruses depend on the host endoplasmic reticulum (ER) glycoprotein folding pathway. In 2014, Sadat et al. reported two siblings with a rare genetic defect in ER α-gl