Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alessandro Schipani"'
Publikováno v:
J Antimicrob Chemother
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
OBJECTIVES: Lack of data on the pharmacokinetics of efavirenz in pregnant women at the 400 mg reduced dose currently prevents universal roll out. Population pharmacokinetic modeling was used to explore pharmacokinetic end-points at 200, 400, and 600
Autor:
Gerry Davies, Alessandro Schipani, Elizabeth Molyneux, Steve A. Ward, Rachel Mlota, Fraction K. Dzinjalamala, Saye Khoo, Henry Pertinez, Joep J. van Oosterhout, Nuria Lopez
Publikováno v:
British Journal of Clinical Pharmacology. 81:679-687
AIMS Low rifampicin plasma concentrations can lead to treatment failure and increased risk of developing drug resistant tuberculosis. The objectives of this study were to characterize the population pharmacokinetics (popPK) of rifampicin in Malawian
Autor:
Wouter H. J. Vaes, Kevin Park, Lindsay Byrne, Grzegorz Grynkiewicz, Alessandro Schipani, Jane Lass, Heili Varendi, Andrew M. Selby, Francis P. Crawley, Mark A. Turner, Sarah Siner, Esther van Duijn, Wioletta Maruszak, Rianne deLigt, Neil French, Colin R. Garner, Caroline Earnshaw
Publikováno v:
British Journal of Clinical Pharmacology. 80:157-167
Aims The aims of the study were to compare [14C]-paracetamol ([14C]-PARA) paediatric pharmacokinetics (PK) after administration mixed in a therapeutic dose or an isolated microdose and to develop further and validate accelerator mass spectrometry (AM
Publikováno v:
Clinical Pharmacokinetics. 54:107-116
In clinical practice, antiretroviral regimens are often interrupted or modified for intolerance and toxicity. The objective of this study was to develop an in vitro to in vivo extrapolation (IVIVE) approach to describe the interaction when efavirenz
Autor:
David Back, Adeniyi Olagunju, Saye Khoo, Marco Siccardi, Alessandro Schipani, Andrew Owen, Deirdre Egan
Publikováno v:
Pharmacogenetics and Genomics. 24:459-463
The CYP3A4*22 (c.522-191 CT; rs35599367) single nucleotide polymorphism has been associated with lower CYP3A4 mRNA expression and activity. We investigated the association of CYP3A4*22 with the pharmacokinetics of lopinavir through a population pharm
Publikováno v:
Pharmaceutical Nanotechnology: Innovation and Production ISBN: 9783527800681
Pharmaceutical Nanotechnology: Innovation and Production
Pharmaceutical Nanotechnology: Innovation and Production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f36511d22450046800106e8ad863598
https://doi.org/10.1002/9783527800681.ch15
https://doi.org/10.1002/9783527800681.ch15
Autor:
Saye Khoo, Alessandro Schipani, Giovanni Di Perri, Marco Simiele, Antonio D'Avolio, Howard L. McLeod, Gerry Davies, Charoen Chuchuttaworn, Sonia Rodríguez Novoa, Marco Siccardi, Janelle M. Hoskins, Vincent Soriano, Natpratou Saguenwong, Andrew Owen, David Back, Lorena Baietto, Anne M. Dvorak, Nitipatana Chierakul, Stefano Bonora, Lorena Cuenca
Publikováno v:
Antimicrobial Agents and Chemotherapy. 54:5242-5250
Atazanavir (ATV) plasma concentrations are influenced by CYP3A4 and ABCB1, which are regulated by the pregnane X receptor (PXR; NR1I2). PXR expression is correlated with CYP3A4 in liver in the absence of enzyme inducers. The PXR single nucleotide pol
Autor:
Alex Musso Buendía, Alessandro Schipani, Dolores Gonzalez Pacanowska, Orla K. Mc Carthy, Luis M. Ruiz-Pérez, Reto Brun, Marcel Kaiser, Ian H. Gilbert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3809-3812
Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel lib
Autor:
Corinne Nguyen, Isabel Leal, Dolores González-Pacanowska, Britt-Louise Sahlberg, Alessandro Schipani, Luis M Ruiz-Pérez, Nils Gunnar Johansson, Ian H. Gilbert, Alexander Musso-Buendia, Marcel Kaiser, Ganasan Kasinathan, Gian Filippo Ruda, Reto Brun
Publikováno v:
Journal of Medicinal Chemistry. 49:4183-4195
We report the discovery of novel uracil-based acyclic compounds as inhibitors of deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase), an enzyme involved in nucleotide metabolism that has been identified as a promising target for the developmen
Autor:
Alison Jayne Foster, Andrew Owen, Neill J. Liptrott, Paul Curley, Phill Roberts, James Long, Alessandro Schipani, Philip Martin, Marco Giardiello, Darren Smith, Tom O. McDonald, Saye Khoo, Marco Siccardi, Steven Paul Rannard
Publikováno v:
Advanced healthcare materials. 3(3)
Nanomedicine strategies have produced many commercial products. However, no orally dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of drug particles have demonstrated many benefits, experimentally achieving >25