Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alessandro S Nascimento"'
Autor:
Luana G Morão, Lívia R Manzine, Lívia Oliveira D Clementino, Carsten Wrenger, Alessandro S Nascimento
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271403 (2022)
Structural biology projects are highly dependent on the large-scale expression of soluble protein and, for this purpose, heterologous expression using bacteria or yeast as host systems is usually employed. In this scenario, some of the parameters to
Externí odkaz:
https://doaj.org/article/810187e41b8b4532a2c4ad3e2edc12b8
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174336 (2017)
Molecular docking is an important tool for the discovery of new biologically active molecules given that the receptor structure is known. An excellent environment for the development of new methods and improvement of the current methods is being prov
Externí odkaz:
https://doaj.org/article/5be28301e2c74819ba117df546317f95
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118790 (2015)
Peroxisome proliferator-activated receptors (PPARs) are involved in the control of carbohydrate and lipid metabolism and are considered important targets to treat diabetes mellitus and metabolic syndrome. The available PPAR ligands have several side
Externí odkaz:
https://doaj.org/article/6adb0c9c7a6144f092614ac0f193d70f
Autor:
Marcelo Vizoná Liberato, Alessandro S Nascimento, Steven D Ayers, Jean Z Lin, Aleksandra Cvoro, Rodrigo L Silveira, Leandro Martínez, Paulo C T Souza, Daniel Saidemberg, Tuo Deng, Angela Angelica Amato, Marie Togashi, Willa A Hsueh, Kevin Phillips, Mário Sérgio Palma, Francisco A R Neves, Munir S Skaf, Paul Webb, Igor Polikarpov
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e36297 (2012)
Thiazolidinediones (TZDs) act through peroxisome proliferator activated receptor (PPAR) γ to increase insulin sensitivity in type 2 diabetes (T2DM), but deleterious effects of these ligands mean that selective modulators with improved clinical profi
Externí odkaz:
https://doaj.org/article/a609d0a8ff1a460d97ac8adf04ce50fa
Autor:
Adriano de Freitas Fernandes, Diego Antonio Leonardo, Italo Augusto Cavini, Higor Vinícius Dias Rosa, Jhon Antoni Vargas, Humberto D'Muniz Pereira, Alessandro S. Nascimento, Richard Charles Garratt
Publikováno v:
Cytoskeleton (Hoboken)
Septins possess a conserved guanine nucleotide-binding (G) domain that participates in the stabilization of organized hetero-oligomeric complexes which assemble into filaments, rings and network-like structures. The fruit fly, Drosophila melanogaster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c90d845a124b9ea9dc76c736487555
https://doi.org/10.1002/cm.21740
https://doi.org/10.1002/cm.21740
Autor:
Isabella Sampaio, Felipe Domingues Quatroni, Paula Maria Pincela Lins, Alessandro S. Nascimento, Valtencir Zucolotto
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Studies have shown that the level of ascorbic acid (AA) is reduced in the brain of Alzheimer's disease (AD) patients. However, its effect on amyloid-β 1-42 (Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03053c9e7638c0317178e4afeaa9034
https://pubmed.ncbi.nlm.nih.gov/35588896
https://pubmed.ncbi.nlm.nih.gov/35588896
Publikováno v:
Computational Biology and Chemistry. 103:107830
The correct evaluation of ligand binding free energies by computational methods is still a very challenging active area of research. The most employed methods for these calculations can be roughly classified into four groups: (i) the fastest and less
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8333290954f3bbb9017cccf87f683253
https://doi.org/10.1016/j.compbiolchem.2023.107830
https://doi.org/10.1016/j.compbiolchem.2023.107830
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Infectious diseases account for 25% of the causes of death worldwide and this rate is expected to increase with the increasing rate of antibiotic resistance observed for many pathogens. Among the bacterial pathogens usually found in healthcare associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb107b4fbeba35085f7363894d40821a
Autor:
Luana G. Morão, Lívia R. Manzine, Lívia Oliveira D. Clementino, Carsten Wrenger, Alessandro S. Nascimento
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Structural biology projects are highly dependent on the large-scale expression of soluble protein and, for this purpose, heterologous expression using bacteria or yeast as host systems is usually employed. In this scenario, some of the parameters to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d485440ae46cb4c921662573b2abcb
Autor:
Ludmilla Ferreira Cardoso, Mirian Hideco Takahashi, Léa Maria Zanini Maciel, Alessandro S. Nascimento, Maria Clara C. Melo, Maria Izabel Chiamolera
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Among the inheritable forms of impaired sensitivity to thyroid hormone, resistance to thyroid hormone (RTH) due to mutations in the thyroid hormone receptor beta gene (THRB) is the first and best known described defect, revealing a wide phenotypic va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5606cd155b72833dc36bdf0190582d1f
https://doi.org/10.1007/s12020-019-02177-4
https://doi.org/10.1007/s12020-019-02177-4