Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Alessandro Fiorenzano"'
Autor:
Jessica Giacomoni, Malin Åkerblom, Mette Habekost, Alessandro Fiorenzano, Janko Kajtez, Marcus Davidsson, Malin Parmar, Tomas Björklund
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal
Externí odkaz:
https://doaj.org/article/c3d7e2d6b3b847adb1d3068e5cf75a20
Autor:
Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
3D brain organoids have been used to investigate human brain development and pathology. Here the authors establish human ventral midbrain organoids coupled with single cell sequencing to study developing and mature dopamine neurons and use silk scaff
Externí odkaz:
https://doaj.org/article/0673168cfbbc48178fafc719524f253a
Autor:
Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Human pluripotent stem cells (hPSCs) are intrinsically able to self-organize into cerebral organoids that mimic features of developing human brain tissue. These three-dimensional structures provide a unique opportunity to generate cytoarchitecture an
Externí odkaz:
https://doaj.org/article/dc93822d588747b9a5b8c9265e0e8c2f
Autor:
Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
What happens to cells on engrafting into the brain in animal models to treat Parkinson’s disease is unclear. Here, the authors use scRNA-seq to examine ventral midbrain (VM)-patterned human embryonic stem cells after functional maturation in a pre-
Externí odkaz:
https://doaj.org/article/e42834ed181548b18cc8c7636ddae20d
Autor:
Katarína Tiklová, Åsa K. Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M. Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Midbrain dopamine (mDA) neurons are significantly associated with Parkinson’s disease and yet there is no systematic molecular classification of these heterogenous group of cells. Here authors use single cell RNA sequencing of isolated mouse neuron
Externí odkaz:
https://doaj.org/article/fb22d9e2478a422ebc121e8f033474f4
Autor:
Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/6ac80cd882654bf0a6f605aa0b6b1832
Publikováno v:
Heliyon, Vol 7, Iss 1, Pp e06006- (2021)
The focal and progressive degeneration of dopaminergic (DA) neurons in ventral midbrain has made Parkinson's disease (PD) a particularly interesting target of cell-based therapies. However, ethical issues and limited tissue availability have so far h
Externí odkaz:
https://doaj.org/article/31fa67903fad49faa53afa3098635d23
Autor:
Alessandro Fiorenzano, Emilia Pascale, Miriam Gagliardi, Sara Terreri, Mariarosaria Papa, Gennaro Andolfi, Marco Galasso, Guidantonio Malagoli Tagliazucchi, Cristian Taccioli, Eduardo Jorge Patriarca, Amelia Cimmino, Maria Rosaria Matarazzo, Gabriella Minchiotti, Annalisa Fico
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1102-1114 (2018)
Summary: Ultraconserved elements (UCEs) show the peculiar feature to retain extended perfect sequence identity among human, mouse, and rat genomes. Most of them are transcribed and represent a new family of long non-coding RNAs (lncRNAs), the transcr
Externí odkaz:
https://doaj.org/article/bbcec8936cdb47ab9c8c289817ab1e11
Publikováno v:
Cells, Vol 10, Iss 6, p 1366 (2021)
Human midbrain dopamine (DA) neurons are a heterogeneous group of cells that share a common neurotransmitter phenotype and are in close anatomical proximity but display different functions, sensitivity to degeneration, and axonal innervation targets.
Externí odkaz:
https://doaj.org/article/cb33c8e7735e41b0b08cb8ee45963ebd
Autor:
Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar, Alessandro Fiorenzano
Publikováno v:
Cells, Vol 10, Iss 1, p 137 (2021)
Dopaminergic (DA) neurons derived from human pluripotent stem cells (hPSCs) represent a renewable and available source of cells useful for understanding development, developing disease models, and stem-cell therapies for Parkinson’s disease (PD). T
Externí odkaz:
https://doaj.org/article/0f9abac234384317a6324d53719a0b38