Can repetitive mechanical motion cause structural damage to axons?

Autor: Allegra Coppini, Alessandro Falconieri, Oz Mualem, Syeda Rubaiya Nasrin, Marine Roudon, Gadiel Saper, Henry Hess, Akira Kakugo, Vittoria Raffa, Orit Shefi

Publikováno v: Frontiers in Molecular Neuroscience, Vol 17 (2024)

Biological structures have evolved to very efficiently generate, transmit, and withstand mechanical forces. These biological examples have inspired mechanical engineers for centuries and led to the development of critical insights and concepts. Howev

Externí odkaz: https://doaj.org/article/fd2c687c3e0b4e029da7d9902252fb9f

Axonal plasticity in response to active forces generated through magnetic nano-pulling

Autor: Alessandro Falconieri, Sara De Vincentiis, Valentina Cappello, Domenica Convertino, Ravi Das, Samuele Ghignoli, Sofia Figoli, Stefano Luin, Frederic Català-Castro, Laura Marchetti, Ugo Borello, Michael Krieg, Vittoria Raffa

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111912- (2023)

Summary: Mechanical force is crucial in guiding axon outgrowth before and after synapse formation. This process is referred to as “stretch growth.” However, how neurons transduce mechanical input into signaling pathways remains poorly understood.

Externí odkaz: https://doaj.org/article/9ab45ee58a614195b9d976dbcd93daa9

Extremely Low Forces Induce Extreme Axon Growth

Autor: Sara De Vincentiis, Vittoria Raffa, Luciana Dente, Vincenzo Scribano, Ranieri Bizzarri, Barbara Storti, Alessandro Falconieri, Mario Costa, Valentina Cappello, Marco Mainardi

Publikováno v: The journal of neuroscience (Online) 40 (2020): 4997–5007. doi:10.1523/JNEUROSCI.3075-19.2020
info:cnr-pdr/source/autori:de Vincentiis S.; Falconieri A.; Mainardi M.; Cappello V.; Scribano V.; Bizzarri R.; Storti B.; Dente L.; Costa M.; Raffa V./titolo:Extremely Low Forces Induce Extreme Axon Growth/doi:10.1523%2FJNEUROSCI.3075-19.2020/rivista:The journal of neuroscience (Online)/anno:2020/pagina_da:4997/pagina_a:5007/intervallo_pagine:4997–5007/volume:40
J Neurosci

Stretch-growth has been defined as a process that extends axons via the application of mechanical forces. In the present article, we used a protocol based on magnetic nanoparticles (NPs) for labeling the entire axon tract of hippocampal neurons, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c235d664390a44c6e6a32346ce597c40
https://doi.org/10.1523/jneurosci.3075-19.2020

Manipulation of Axonal Outgrowth via Exogenous Low Forces

Autor: Alessandro Falconieri, Sara De Vincentiis, Vittoria Raffa, Samuele Ghignoli, Vincenzo Scribano

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 8009, p 8009 (2020)

Neurons are mechanosensitive cells. The role of mechanical force in the process of neurite initiation, elongation and sprouting; nerve fasciculation; and neuron maturation continues to attract considerable interest among scientists. Force is an endog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec6d4262b332139204a2814784c7d257
https://pubmed.ncbi.nlm.nih.gov/33126477

Recent advances in the use of magnetic nanoparticles to promote neuroregeneration

Autor: Alessandro Falconieri, Vittoria Raffa, Sara De Vincentiis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65acd3f950205aa84409254eb1610aa8
http://hdl.handle.net/11568/988710