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pro vyhledávání: '"Alessandro Dimasi"'
Autor:
Andrea Citarella, Alessandro Dimasi, Davide Moi, Daniele Passarella, Angela Scala, Anna Piperno, Nicola Micale
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1339 (2023)
The main protease (Mpro) plays a pivotal role in the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is considered a highly conserved viral target. Disruption of the catalytic activity of Mpro produces a detrimental ef
Externí odkaz:
https://doaj.org/article/00eeeba6b2bc47d191e6df9db6aefe8d
Autor:
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Alessandro Dimasi, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Clelia Giannini, Daniele Passarella
Publikováno v:
Organic & Biomolecular Chemistry. 21:3811-3824
A panel of novel cinnamic ester derivatives showed a potent inhibitory effect against SARS-CoV-2 Mpro and efficiently impaired the in vitro replication of two human coronaviruses in the low micromolar range.