Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Alessandro Bona"'
Autor:
Marta Giorgis, Donatella Boschi, Barbara Buccinnà, Stefano Sainas, Mariia Mishina, Davide Bonanni, Alice Passoni, Salam Al-Karadaghi, Yaqi Qiu, Cristina Ramondetti, Paola Circosta, Giuseppe Saglio, Marco Piccinini, Valentina Gaidano, Mohammad Houshmand, Alessandro Bona, Alessandro Cignetti, Enrico Giraudo, Carina Florina Cojocaru, Marco Lucio Lolli, Barbara Rolando, Renzo Bagnati, Agnese Chiara Pippione, Barbara Canepa
Publikováno v:
Journal of Medicinal Chemistry. 64:5404-5428
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c81addc6474b683c17e342be6dc2c
https://doi.org/10.1021/acs.jmedchem.0c01549
https://doi.org/10.1021/acs.jmedchem.0c01549
Autor:
Alessio Nocentini, Anna Di Porzio, Alessandro Bonardi, Carla Bazzicalupi, Andrea Petreni, Tarita Biver, Silvia Bua, Simona Marzano, Jussara Amato, Bruno Pagano, Nunzia Iaccarino, Stefano De Tito, Stefano Amente, Claudiu T. Supuran, Antonio Randazzo, Paola Gratteri
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small molecules has emerged as an antic
Externí odkaz:
https://doaj.org/article/72c74b1aaac342a2836205f0ff910408
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA novel series of hydantoins incorporating phthalimides has been synthesised by condensation of activated phthalimides with 1-aminohydantoin and investigated for their inhibitory activity against a panel of human (h) carbonic anhydrase (CA, E
Externí odkaz:
https://doaj.org/article/e4dede48e0c541abb1dbd975df0400c2
Autor:
Alessandro Bonaccorso, Giuseppe Falzone, Angelo Ferro, Salvatore Gambino, Giuseppe Laudani, Laura Privitera
Publikováno v:
Earth, Planets and Space, Vol 76, Iss 1, Pp 1-14 (2024)
Abstract Etna is a highly active volcano with frequent eruptions and is closely observed with different monitoring techniques. One of the monitoring methods is a network of short-base tiltmeters that provides continuous control of ground deformation.
Externí odkaz:
https://doaj.org/article/d4da3f59b0774849a00e37ac97abc60f
Autor:
Stefano, Sainas, Marta, Giorgis, Paola, Circosta, Valentina, Gaidano, Davide, Bonanni, Agnese C, Pippione, Renzo, Bagnati, Alice, Passoni, Yaqi, Qiu, Carina Florina, Cojocaru, Barbara, Canepa, Alessandro, Bona, Barbara, Rolando, Mariia, Mishina, Cristina, Ramondetti, Barbara, Buccinnà, Marco, Piccinini, Mohammad, Houshmand, Alessandro, Cignetti, Enrico, Giraudo, Salam, Al-Karadaghi, Donatella, Boschi, Giuseppe, Saglio, Marco L, Lolli
Publikováno v:
Journal of Medicinal Chemistry
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95d65008168d44ed9e2830b4469d53dd
https://pubmed.ncbi.nlm.nih.gov/33844533
https://pubmed.ncbi.nlm.nih.gov/33844533
Autor:
Rouaa Ben Chaabene, Matthew Martinez, Alessandro Bonavoglia, Bohumil Maco, Yi-Wei Chang, Gaëlle Lentini, Dominique Soldati-Favre
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002745 (2024)
Rhoptries are specialized secretory organelles conserved across the Apicomplexa phylum, essential for host cell invasion and critical for subverting of host cellular and immune functions. They contain proteins and membranous materials injected direct
Externí odkaz:
https://doaj.org/article/06ed8fb477954bc8abcfc94e0e4ec231
Autor:
Alessandro Bonari, Mauro Leucio Mattei, Giovanni Cappelli, Francesca Romano, Nicoletta Cini, Francesca Luceri, Donato Squillaci, Stefano Dugheri, Alessandra Fanelli, Nicola Mucci
Publikováno v:
Practical Laboratory Medicine, Vol 41, Iss , Pp e00424- (2024)
Background: Since ancient times, poisoning, even serious poisoning, has been known to occur during nature walks. Intentional or unintentional ingestion of toxins of animal origin is one of the possible causes of poisoning. Bufadienolide poisoning is
Externí odkaz:
https://doaj.org/article/3c292ea884f642a39ab3279ef916028e
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1, Pp 156-165 (2023)
A one-pot two-step protocol was developed for the synthesis of a series of novel 4-cyanamidobenzenesulfonamides from easily accessible methyl (4-sulfamoylphenyl)-carbamimidothioate. The new sulphonamides were investigated as inhibitors of the enzyme
Externí odkaz:
https://doaj.org/article/b78f5378e4f54145a14a8b22ba1dd3de
Discovery of the first-in-class potent and isoform-selective human carbonic anhydrase III inhibitors
Autor:
Simone Giovannuzzi, Alessandro Bonardi, Paola Gratteri, Alessio Nocentini, Claudiu T. Supuran
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Considering the unrecognised physio-pathological role of human carbonic anhydrase III (hCA III), a structure-based drug design was set up to identify the first-in-class potent and selective inhibitors of this neglected isoform. hCA III targeting was
Externí odkaz:
https://doaj.org/article/0d1cac7dbab14fcaad0a75ab557ea796