Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Alessandro Bitto"'
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Aging and obesity are common risk factors for numerous chronic pathologies, and the compounding effects of old age and increased adiposity pose a serious threat to public health. Starting from the assumption that aging and obesity may have shared und
Externí odkaz:
https://doaj.org/article/341aca0af58541e7843009afda8c5ddb
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James J. Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Externí odkaz:
https://doaj.org/article/c99404f4c52046d6b736e90ad388d71e
Autor:
Takashi K. Ito, Chenhao Lu, Jacob Khan, Quy Nguyen, Heather Z. Huang, Dayae Kim, James Phillips, Jo Tan, Yenna Lee, Tuyet Nguyen, Samy Khessib, Natalie Lim, Surapat Mekvanich, Joshua Oh, Victor V. Pineda, Weirong Wang, Alessandro Bitto, Jonathan Y. An, John F. Morton, Mitsutoshi Setou, Warren C. Ladiges, Matt Kaeberlein
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
The inactivation of ribosomal protein S6 kinase 1 (S6K1) recapitulates aspects of caloric restriction and mTORC1 inhibition to achieve prolonged longevity in invertebrate and mouse models. In addition to delaying normative aging, inhibition of mTORC1
Externí odkaz:
https://doaj.org/article/b9e4abcd91a34deea0dfa54c43c48b29
Autor:
Christopher F Bennett, Jane J Kwon, Christine Chen, Joshua Russell, Kathlyn Acosta, Nikolay Burnaevskiy, Matthew M Crane, Alessandro Bitto, Helen Vander Wende, Marissa Simko, Victor Pineda, Ryan Rossner, Brian M Wasko, Haeri Choi, Shiwen Chen, Shirley Park, Gholamali Jafari, Bryan Sands, Carissa Perez Olsen, Alexander R Mendenhall, Philip G Morgan, Matt Kaeberlein
Publikováno v:
PLoS Genetics, Vol 13, Iss 3, p e1006695 (2017)
Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously,
Externí odkaz:
https://doaj.org/article/16244a054fa74a9d8488d864fa5e9844
Autor:
Alessandro Bitto, Takashi K Ito, Victor V Pineda, Nicolas J LeTexier, Heather Z Huang, Elissa Sutlief, Herman Tung, Nicholas Vizzini, Belle Chen, Kaleb Smith, Daniel Meza, Masanao Yajima, Richard P Beyer, Kathleen F Kerr, Daniel J Davis, Catherine H Gillespie, Jessica M Snyder, Piper M Treuting, Matt Kaeberlein
Publikováno v:
eLife, Vol 5 (2016)
The FDA approved drug rapamycin increases lifespan in rodents and delays age-related dysfunction in rodents and humans. Nevertheless, important questions remain regarding the optimal dose, duration, and mechanisms of action in the context of healthy
Externí odkaz:
https://doaj.org/article/789d01e84d514ea888c6cbb9326c49be
Autor:
Rekha Bhat, Elizabeth P Crowe, Alessandro Bitto, Michelle Moh, Christos D Katsetos, Fernando U Garcia, Frederick Bradley Johnson, John Q Trojanowski, Christian Sell, Claudio Torres
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45069 (2012)
Aging is the main risk factor for Alzheimer's disease (AD); however, the aspects of the aging process that predispose the brain to the development of AD are largely unknown. Astrocytes perform a myriad of functions in the central nervous system to ma
Externí odkaz:
https://doaj.org/article/ff4588c5141641a39e02a1d9cb6d6b17
Autor:
Alessandro Bitto, Chad Lerner, Claudio Torres, Michaela Roell, Marco Malaguti, Viviana Perez, Antonello Lorenzini, Silvana Hrelia, Yuji Ikeno, Michelle Elizabeth Matzko, Roger McCarter, Christian Sell
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12592 (2010)
A reduction in IGF-I signaling has been found to increase lifespan in multiple organisms despite the fact that IGF-I is a trophic factor for many cell types and has been found to have protective effects against multiple forms of damage in acute setti
Externí odkaz:
https://doaj.org/article/e420605603604e01bfb99bab7f48bf22
Autor:
Jeremy A. Whitson, Richard Johnson, Lu Wang, Theo K. Bammler, Shin-Ichiro Imai, Huiliang Zhang, Jeanne Fredrickson, Elena Latorre-Esteves, Alessandro Bitto, Michael J. MacCoss, Peter S. Rabinovitch
Publikováno v:
GeroScience
We analyzed the effects of aging on protein abundance and acetylation, as well as the ability of the mitochondrial-targeted drugs elamipretide (SS-31) and nicotinamide mononucleotide (NMN) to reverse aging-associated changes in mouse hearts. Both dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5db666e279b22bc3cdf8c5a4d9c7b1
https://doi.org/10.1007/s11357-022-00564-w
https://doi.org/10.1007/s11357-022-00564-w
Autor:
Alessandro Bitto, Judit Villén, Lu Wang, Michael J. MacCoss, Alexander Mendenhall, Peter S. Rabinovitch, Yuliang Wang, Daniel E. L. Promislow, Warren Ladiges, Su-In Lee, Matt Kaeberlein, Maitreya J. Dunham, Jessica E. Young
Publikováno v:
GeroScience
The University of Washington Nathan Shock Center of Excellence in the Basic Biology of Aging provides leadership and resources to support the geroscience community locally, nationally, and internationally. Services are provided through our Resource C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3b113c3f9cd4bd1a4e5b2be7d28c38
https://doi.org/10.1007/s11357-021-00413-2
https://doi.org/10.1007/s11357-021-00413-2
Autor:
Alessandro Bitto, Anthony S. Grillo, Ian B. Stanaway, Bao M. G. Nguyen, Kejun Ying, Herman Tung, Kaleb Smith, Ngoc Tran, Gunnar Velikanje, Silvan R. Urfer, Jessica M. Snyder, Ernst-Bernhard Kayser, Lu Wang, Daniel L. Smith, J. Will Thompson, Laura DuBois, William DePaolo, Matt Kaeberlein
SummaryMitochondrial diseases represent a spectrum of disorders caused by impaired mitochondrial function ranging in severity from mortality during infancy to progressive adult-onset disease. Mitochondrial dysfunction is also recognized as a molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::817c65e0d1ddc61c6ca25fd0f2f3062a
https://doi.org/10.1101/2022.01.31.478591
https://doi.org/10.1101/2022.01.31.478591
