Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Alessandro B. C. Simas"'
Autor:
Daniel A. S. Kitagawa, Rafael B. Rodrigues, Thiago N. Silva, Wellington V. dos Santos, Vinicius C. V. da Rocha, Joyce S. F. D. de Almeida, Leandro B. Bernardo, Taynara Carvalho-Silva, Cintia N. Ferreira, Angelo A. T. da Silva, Alessandro B. C. Simas, Eugenie Nepovimova, Kamil Kuča, Tanos C. C. França, Samir F. de A. Cavalcante
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)
Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro
Externí odkaz:
https://doaj.org/article/64caf545eedf4c7299e2546a21467177
Autor:
Samir F. de A. Cavalcante, Alessandro B. C. Simas, Marcos C. Barcellos, Victor G. M. de Oliveira, Roberto B. Sousa, Paulo A. de M. Cabral, Kamil Kuča, Tanos C. C. França
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 414 (2020)
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare
Externí odkaz:
https://doaj.org/article/3fad8319ca9440ee84e2b8cbdf4572ba
Autor:
Jaqueline D. Senra, Aires C. Silva, Raquel V. Santos, Luiz Fernando B. Malta, Alessandro B. C. Simas
Publikováno v:
Journal of Chemistry, Vol 2017 (2017)
In this work, a new catalytic approach for the C-O activation of enol phosphates based on a palladium supported on layered double hydroxide was developed. In this case, two different ketene aminal phosphates were used as models to study the synthesis
Externí odkaz:
https://doaj.org/article/60db129ba1274c08820083a9b209ee92
Autor:
Daniel A. S. Kitagawa, Samir F. de A. Cavalcante, Reuel L. de Paula, Rafael B. Rodrigues, Leandro B. Bernardo, Munique C. J. da Silva, Thiago N. da Silva, Wellington V. dos Santos, José M. Granjeiro, Joyce S. F. D. de Almeida, Marcos C. Barcellos, Ana Beatriz de A. Correa, Tanos C. C. França, Kamil Kuča, Alessandro B. C. Simas
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 583 (2019)
Casualties caused by organophosphorus pesticides are a burden for health systems in developing and poor countries. Such compounds are potent acetylcholinesterase irreversible inhibitors, and share the toxic profile with nerve agents. Pyridinium oxime
Externí odkaz:
https://doaj.org/article/04b576b9b7084a1d8cfbf4f2aca184c0
Autor:
Reuel L. de Paula, Joyce S. F. D. de Almeida, Samir F. A. Cavalcante, Arlan S. Gonçalves, Alessandro B. C. Simas, Tanos C. C. Franca, Martin Valis, Kamil Kuca, Eugenie Nepovimova, José M. Granjeiro
Publikováno v:
Molecules, Vol 23, Iss 11, p 2954 (2018)
The present work aimed to compare the small, neutral and monoaromatic oxime, isatin-3-oxime (isatin-O), to the commercial ones, pralidoxime (2-PAM) and obidoxime, in a search for a new potential reactivator for acetylcholinesterase (AChE) inhibited b
Externí odkaz:
https://doaj.org/article/32a4eb8b5b844ae982c3efbd9cc00914
Autor:
Alessandro B. C. Simas, Vera L. P. Pereira, Cleber B. Barreto Jr., Daniel L. de Sales, Leandro L. de Carvalho
Publikováno v:
Química Nova, Vol 32, Iss 9, Pp 2473-2475 (2009)
Despite the availability of alternative methods for drying tetrahydrofuran (THF), the use of the still apparatus, wherein a THF solution containing Na-bezophenone ketyl is heated to reflux, remains widespread. We herein propose a set of procedures to
Externí odkaz:
https://doaj.org/article/a2f3d4645e8b48e6bf6dfda6eb4e4bd8
Autor:
Samir F. de A. Cavalcante, Daniel A. S. Kitagawa, Rafael B. Rodrigues, Monique Cardozo, Reuel L. de Paula, Ana Beatriz de A. Correa, Alessandro B. C. Simas
Publikováno v:
Química Nova, Vol 41, Iss 10, Pp 1192-1195
Straightforward, microscale, Ellman's cholinesterase test procedures are presented, useful for screening of novel compounds aiming at neurodegenerative diseases and antidotes towards nerve agents and pesticides. Herein, we detail the different proced
Externí odkaz:
https://doaj.org/article/d84457d1c9b64370b2f1b5bf081fb33b
Autor:
Danilo Predes, Lorena A. Maia, Isadora Matias, Hannah Paola Mota Araujo, Carolina Soares, Fernanda G. Q. Barros-Aragão, Luiz F. S. Oliveira, Renata R. Reis, Nathalia G. Amado, Alessandro B. C. Simas, Fabio A. Mendes, Flávia C. A. Gomes, Claudia P. Figueiredo, Jose G. Abreu
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12078
The Wnt/β-catenin signaling pathway dictates cell proliferation and differentiation during embryonic development and tissue homeostasis. Its deregulation is associated with many pathological conditions, including neurodegenerative disease, frequentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d8bb1cf12ca9bca8133b559f91e66e6
Autor:
Tanos C. C. França, Angelo A.T. da Silva, Leandro B. Bernardo, Eugenie Nepovimova, Vinicius C V da Rocha, Taynara Carvalho-Silva, Thiago H. Silva, Cintia N. Ferreira, Joyce S. F. D. de Almeida, Wellington V Dos Santos, Rafael B. Rodrigues, Samir F. de A. Cavalcante, Kamil Kuca, Daniel A. S. Kitagawa, Alessandro B. C. Simas
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1369-1376 (2021)
Organophosphorus poisoning caused by some pesticides and nerve agents is a life-threating condition that must be swiftly addressed to avoid casualties. Despite the availability of medical countermeasures, the clinically available compounds lack a bro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d48cd3065be20ef284226717b5ba8
https://doi.org/10.1080/14756366.2021.1916009
https://doi.org/10.1080/14756366.2021.1916009
