Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Alessandro A Sartori"'
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
DNA double-strand breaks (DSBs) are one of the most detrimental lesions, as their incorrect or incomplete repair can lead to genomic instability, a hallmark of cancer. Cells have evolved two major competing DSB repair mechanisms: Homologous recombina
Externí odkaz:
https://doaj.org/article/f04af76d95f24b46a30f2438b35d117e
Publikováno v:
Swiss Medical Weekly, Vol 143, Iss 3132 (2013)
Externí odkaz:
https://doaj.org/article/3030a8d4c36a40f0aa65d89ddcda0aab
Publikováno v:
Frontiers in Genetics, Vol 4 (2013)
DNA double-strand breaks (DSBs) are repaired by two major pathways: homologous recombination (HR) and nonhomologous end-joining (NHEJ). The choice between HR and NHEJ is highly regulated during the cell cycle. DNA-end resection, an evolutionarily con
Externí odkaz:
https://doaj.org/article/a36290c60c234867b5a64e9fef5fb1fb
Autor:
Anu Sharma, Beata Bode, Roland H Wenger, Kuno Lehmann, Alessandro A Sartori, Holger Moch, Alexander Knuth, Lotta von Boehmer, Maries van den Broek
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28217 (2011)
BACKGROUND: γ-radiation is an effective treatment for cancer. There is evidence that radiotherapy supports tumor-specific immunity. It was described that irradiation induces de novo protein synthesis and enhances antigen presentation, we therefore i
Externí odkaz:
https://doaj.org/article/e60bca425d204e78b70e27d03d17968b
Autor:
Anika Trenner, Alessandro A. Sartori
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
DNA double-strand breaks (DSBs) are highly deleterious, with a single unrepaired DSB being sufficient to trigger cell death. Compared to healthy cells, cancer cells have a higher DSB burden due to oncogene-induced replication stress and acquired defe
Externí odkaz:
https://doaj.org/article/e1d9de9440b64b93a39d1679ac6bfe34
Autor:
Diego Dibitetto, Martin Liptay, Francesca Vivalda, Ewa Gogola, Hulya Dogan, Martín G. Fernández, Alexandra Duarte, Jonas A. Schmid, Stephen T. Durant, Josep V. Forment, Ismar Klebic, Myriam Siffert, Roebi de Bruijn, Arne N. Kousholt, Nicole A. Marti, Martina Dettwiler, Claus S. Sørensen, Massimo Lopes, Alessandro A. Sartori, Jos Jonkers, Sven Rottenberg
Histone H2AX plays a key role in DNA damage signalling in the surrounding regions of DNA double-strand breaks (DSBs)1,2. In response to DNA damage, H2AX becomes phosphorylated on serine residue 139 (known as γH2AX), resulting in the recruitment of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::175ac711ecfb0ec05959a4002e1d3ac8
https://doi.org/10.1101/2023.05.22.541781
https://doi.org/10.1101/2023.05.22.541781
Table S1: Primary antibodies; Table S2: Secondary antibodies; Table S3: siRNA oligos; Figure S1, related to Figure 1: BRC4 peptide inhibits RAD51 binding to BRCA2 and RAD51 self-oligomerization; Figure S2; related to Figure 2: Efficient cellular upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80247818e0f05e9d656ae3c3b4a7e232
https://doi.org/10.1158/1535-7163.22506277
https://doi.org/10.1158/1535-7163.22506277
Under conditions of genotoxic stress, cancer cells strongly rely on efficient DNA repair to survive and proliferate. The human BRCA2 tumor suppressor protein is indispensable for the repair of DNA double-strand breaks by homologous recombination (HR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b555709e2ee1f449be184b5914d71e4
https://doi.org/10.1158/1535-7163.c.6538342.v1
https://doi.org/10.1158/1535-7163.c.6538342.v1
Autor:
Ilaria Ceppi, Elda Cannavo, Hélène Bret, Rosa Camarillo, Francesca Vivalda, Roshan Singh Thakur, Amador Romero-Franco, Alessandro A. Sartori, Pablo Huertas, Raphaël Guérois, Petr Cejka
Publikováno v:
Genes & Development, 37 (3-4)
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11-RAD50-NBS1 (MRN) to endonucleolytically cleave 5'-terminated DNA to bypass protein blocks. CtIP also promotes the DNA2 helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac9824f539b89d495c328ea2f8a122d
https://hdl.handle.net/20.500.11850/605845
https://hdl.handle.net/20.500.11850/605845
Autor:
Olga Murina, Christine von Aesch, Ufuk Karakus, Lorenza P. Ferretti, Hella A. Bolck, Kay Hänggi, Alessandro A. Sartori
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1030-1038 (2014)
The resolution of DNA interstrand crosslinks (ICLs) requires a complex interplay between several processes of DNA metabolism, including the Fanconi anemia (FA) pathway and homologous recombination (HR). FANCD2 monoubiquitination and CtIP-dependent DN
Externí odkaz:
https://doaj.org/article/988e5ca39e1a4d99a128e310b7eac278