Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Alessandra Silvani"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 303-308 (2022)
Addressing the asymmetric synthesis of oxindole-based α-aminoboronic acids, instead of the expected products we disclosed the efficient homocoupling of oxindole-based N-tert-butanesulfinyl imines, with the generation of chiral, quaternary 1,2-diamin
Externí odkaz:
https://doaj.org/article/f0e6b4abae70475aa3cd9e55ae28b46f
Autor:
Enrico M. A. Fassi, Marco Manenti, Andrea Citarella, Michele Dei Cas, Sara Casati, Nicola Micale, Tanja Schirmeister, Gabriella Roda, Alessandra Silvani, Giovanni Grazioso
Publikováno v:
Molecules, Vol 28, Iss 5, p 2356 (2023)
The COVID-19 pandemic has given a strong impetus to the search for antivirals active on SARS-associated coronaviruses. Over these years, numerous vaccines have been developed and many of these are effective and clinically available. Similarly, small
Externí odkaz:
https://doaj.org/article/8f09dc5c157241ebbceaacde68e34aae
Autor:
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Daniele Passarella, Clelia Giannini
Publikováno v:
Molecules, Vol 28, Iss 2, p 514 (2023)
SARS-CoV-2 Mpro is a chymotrypsin-like cysteine protease playing a relevant role during the replication and infectivity of SARS-CoV-2, the coronavirus responsible for COVID-19. The binding site of Mpro is characterized by the presence of a catalytic
Externí odkaz:
https://doaj.org/article/fd5e75a5ccd442329d507b6342d1c2af
Publikováno v:
Polymers, Vol 12, Iss 10, p 2396 (2020)
The first example of solvent-free, organocatalyzed, polymerization of 1,3-dioxolan-4-ones, used as easily accessible monomers for the synthesis of polylactic acid (PLA), is described here. An optimization of reaction conditions was carried out, with
Externí odkaz:
https://doaj.org/article/19843a5deb7e476dac30e346dd94d15b
Autor:
Emanuele Bassini, Stefano Gazzotti, Filomena Sannio, Leonardo Lo Presti, Jacopo Sgrignani, Jean-Denis Docquier, Giovanni Grazioso, Alessandra Silvani
Publikováno v:
Antibiotics, Vol 9, Iss 5, p 249 (2020)
The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers–three components versions, an
Externí odkaz:
https://doaj.org/article/1b289cdc4a5d40dbab698a1c7e9e488f
Autor:
Giordano Lesma, Fiorella Meneghetti, Alessandro Sacchetti, Mattia Stucchi, Alessandra Silvani
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1383-1389 (2014)
An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed. The reactions proceeded smoothly and in a stereocontrolled manner with regard to the new cent
Externí odkaz:
https://doaj.org/article/02a647561ae84b23b7b69946f43b2bc9
Autor:
Francesco Airaghi, Andrea Fiorati, Giordano Lesma, Manuele Musolino, Alessandro Sacchetti, Alessandra Silvani
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 147-154 (2013)
Aiming at restricting the conformational freedom of tryptophan-containing peptide ligands, we designed a THBC (tetrahydro-β-carboline)-DKP (diketopiperazine)-based peptidomimetic scaffold capable of arranging in an unusual α-turn conformation. The
Externí odkaz:
https://doaj.org/article/d8a4593719364517a9a670aa59667958
Publikováno v:
Molecules, Vol 22, Iss 11, p 2016 (2017)
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates
Externí odkaz:
https://doaj.org/article/9fa68edf422c4fb6999adc32a4995498
Autor:
Andrea Citarella, Davide Moi, Martina Pedrini, Helena Pérez-Peña, Stefano Pieraccini, Alessandro Dimasi, Claudio Stagno, Nicola Micale, Tanja Schirmeister, Giulia Sibille, Giorgio Gribaudo, Alessandra Silvani, Clelia Giannini, Daniele Passarella
Publikováno v:
Organic & Biomolecular Chemistry. 21:3811-3824
A panel of novel cinnamic ester derivatives showed a potent inhibitory effect against SARS-CoV-2 Mpro and efficiently impaired the in vitro replication of two human coronaviruses in the low micromolar range.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bbb8c08deeebf180f9bebf1f8c6ece
https://doi.org/10.1039/d3ob00381g
https://doi.org/10.1039/d3ob00381g
Fully regioselective synthesis of 5-hydroxyethylpyrazoles was exploited by reacting hydrazonoyl chlorides with homopropargylic alcohols in the presence of catalytic amounts of copper(I) chloride. Good yields of pyrazolic products and mild reaction co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3c9dc23a57e3ee3d8317229e88e56b
https://hdl.handle.net/2434/947589
https://hdl.handle.net/2434/947589
