Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alessandra Polara"'
Autor:
Michael Honer, Alessandra Polara, Hiroto Kuwabara, Helmut Jacobsen, Axel Pähler, Thomas Hartung, Antonello Caruso, Daria Esterhazy, Markus Stoffel, Robert F. Dannals, Dean F. Wong, Edilio Borroni, Luca C. Gobbi
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1e7a5a455c4e77c70b6a67ad02ae82
https://doi.org/10.1002/jlcr.4025
https://doi.org/10.1002/jlcr.4025
Autor:
Pascale David-Pierson, David Banner, Wolfgang Wostl, Wolfgang Guba, Emmanuel Pinard, Thorsten Muser, Harald Mauser, Hans Hilpert, Thomas Johannes Woltering, Daniela Krummenacher, Holger Fischer, Alessandra Polara, Schnider Christian, Andreas Kuglstatter, Robert Narquizian, Helmut Jacobsen, Laurence Ozmen, Roland Humm, Alessandra Bergadano, Remo Hochstrasser, Mark Rogers-Evans, Alexander V. Mayweg
Publikováno v:
Journal of Medicinal Chemistry. 56:3980-3995
An extensive fluorine scan of 1,3-oxazines revealed the power of fluorine(s) to lower the pKa and thereby dramatically change the pharmacological profile of this class of BACE1 inhibitors. The CF3 substituted oxazine 89, a potent and highly brain pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb83a85e859669cfa4b43b0b259900cf
https://doi.org/10.1021/jm400225m
https://doi.org/10.1021/jm400225m
Autor:
J. Ruth Gallimore, Gideon M. Hirschfield, Mark B. Pepys, Alessandra Polara, J. Andrew Aquilina, D Thompson, Caroline A. Sabin, Isam Sharif, Vittorio Bellotti, Rebecca M. Myers, Simon Kolstoe, Michelle C. Jenvey, Philip N. Hawkins, Melvyn C. Kahan, Martin D. Smith, Alexander J. A. Cobb, Carol V. Robinson, Stephen P Wood, Glenys A. Tennent, Gillian A. Gray, Steven V. Ley
Complement-mediated inflammation exacerbates the tissue injury of ischaemic necrosis in heart attacks and strokes, the most common causes of death in developed countries. Large infarct size increases immediate morbidity and mortality and, in survivor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf1bc2450e4f08b08521065d2de5fab
https://ora.ox.ac.uk/objects/uuid:bc7e4fca-9fa4-440f-92b5-31f85a526bcb
https://ora.ox.ac.uk/objects/uuid:bc7e4fca-9fa4-440f-92b5-31f85a526bcb
Autor:
Luca Gobbi, Michael Honer, Helmut Jacobsen, Edilio Borroni, Daria Esterházy, Hansruedi Loetscher, Dieter Muri, Alessandra Polara, Markus Stoffel, Thomas Hartung
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9d01a2eee9f3e5d3857d9a1f3628df
https://doi.org/10.1016/j.jalz.2012.05.415
https://doi.org/10.1016/j.jalz.2012.05.415
Publikováno v:
ChemInform. 33
[reaction--see text] The butane-2,3-diacetal (BDA) desymmetrized glycolic acid building block 1 undergoes efficient and highly diastereoselective lithium enolate aldol reactions with both aromatic and aliphatic aldehydes to afford, after an acidic me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bffdf5e86d55b10472132e10ad957c1
https://doi.org/10.1002/chin.200217143
https://doi.org/10.1002/chin.200217143
Publikováno v:
Tetrahedron letters. 49(41)
The mechanism of the cascade oxidative dearomatization–transannular Diels–Alder was investigated in the context of an asymmetric route to (−)-11-O-debenzoyltashironin. Although the oxidative dearomatization provides two acetal intermediates, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39d4a02fb84033794567e33eb292f9a
https://pubmed.ncbi.nlm.nih.gov/19812682
https://pubmed.ncbi.nlm.nih.gov/19812682
Autor:
Steven V. Ley, Alessandra Polara
Publikováno v:
The Journal of organic chemistry. 72(16)
1,2-Diacetals are readily prepared, rigid structural motifs that provide a wide range of opportunities for applications in natural product assembly. These uses encompass selective 1,2-diol or alpha-hydroxy acid protection, enantiotopic recognition an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f3eb32a83959360261bb422a94775a
https://pubmed.ncbi.nlm.nih.gov/17430000
https://pubmed.ncbi.nlm.nih.gov/17430000
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7890ddb9fa38be6434cc6585ec3b82a7
https://doi.org/10.1002/chin.200306089
https://doi.org/10.1002/chin.200306089
Publikováno v:
HELVETICA CHIMICA ACTA. 86(11)
The total synthesis of phytotoxic nonenolide herbarumin II (1) has been achieved by implementation of butane diacetal (BDA)-desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf837478880b173a13e33df12b26f25d
http://ora.ox.ac.uk/objects/uuid:e9c3c245-e4e1-4f07-abdf-92a79175f7cd
http://ora.ox.ac.uk/objects/uuid:e9c3c245-e4e1-4f07-abdf-92a79175f7cd
Publikováno v:
Scopus-Elsevier
ResearcherID
ResearcherID
Butane-2,3-diacetal (BDA) desymmetrised glycolic acid building block 1 undergoes highly diastereoselective lithium enolate ketone aldol reactions with a range of methyl and mono-substituted methyl ketones to yield, after acid-catalysed deprotection,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22efa950f24617fed1d19ca2fd7bb18
http://ora.ox.ac.uk/objects/uuid:16ec88a5-d892-43cf-a10c-a2edcdf5ce8f
http://ora.ox.ac.uk/objects/uuid:16ec88a5-d892-43cf-a10c-a2edcdf5ce8f