Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Alessandra Pasquo"'
Autor:
Maria Petrosino, Leonore Novak, Alessandra Pasquo, Paola Turina, Emidio Capriotti, Velia Minicozzi, Valerio Consalvi, Roberta Chiaraluce
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-23 (2023)
Abstract Mitogen-activated protein kinases 1 and 3 (MAPK1 and MAPK3), also called extracellular regulated kinases (ERK2 and ERK1), are serine/threonine kinase activated downstream by the Ras/Raf/MEK/ERK signal transduction cascade that regulates a va
Externí odkaz:
https://doaj.org/article/629e896713a64b7e8fe68e4a682f963a
Autor:
Leonore Novak, Maria Petrosino, Alessandra Pasquo, Apirat Chaikuad, Roberta Chiaraluce, Stefan Knapp, Valerio Consalvi
Publikováno v:
Cancers, Vol 15, Iss 11, p 2938 (2023)
The extracellular-signal-regulated kinase 2 (ERK2), a mitogen-activated protein kinase (MAPK) located downstream of the Ras-Raf-MEK-ERK signal transduction cascade, is involved in the regulation of a large variety of cellular processes. The ERK2, act
Externí odkaz:
https://doaj.org/article/15ce19976632445fa6d5f802833d5949
Publikováno v:
Sensors, Vol 22, Iss 21, p 8338 (2022)
Fast monitoring of water quality is a fundamental part of environmental management and protection, in particular, the possibility of qualitatively and quantitatively determining its contamination at levels that are dangerous for human health, fauna a
Externí odkaz:
https://doaj.org/article/d00de2d050054a3492414c6a81e5e7b2
Autor:
Felicia Carotenuto, Sara Politi, Arsalan Ul Haq, Fabio De Matteis, Emanuela Tamburri, Maria Letizia Terranova, Laura Teodori, Alessandra Pasquo, Paolo Di Nardo
Publikováno v:
Micromachines, Vol 13, Iss 5, p 780 (2022)
Failure of tissues and organs resulting from degenerative diseases or trauma has caused huge economic and health concerns around the world. Tissue engineering represents the only possibility to revert this scenario owing to its potential to regenerat
Externí odkaz:
https://doaj.org/article/7f2489de3cd64f0e80a97ed1aaa8bc04
Autor:
Arsalan Ul Haq, Felicia Carotenuto, Fabio De Matteis, Paolo Prosposito, Roberto Francini, Laura Teodori, Alessandra Pasquo, Paolo Di Nardo
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8550 (2021)
One of the most important features of striated cardiac muscle is the excitability that turns on the excitation-contraction coupling cycle, resulting in the heart blood pumping function. The function of the heart pump may be impaired by events such as
Externí odkaz:
https://doaj.org/article/9ef662c5009a481091291e2fa8a96b13
Autor:
Maria Petrosino, Leonore Novak, Alessandra Pasquo, Roberta Chiaraluce, Paola Turina, Emidio Capriotti, Valerio Consalvi
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5416 (2021)
Large scale genome sequencing allowed the identification of a massive number of genetic variations, whose impact on human health is still unknown. In this review we analyze, by an in silico-based strategy, the impact of missense variants on cancer-re
Externí odkaz:
https://doaj.org/article/5a0b3dd509aa49b68568b223c8072a6f
Autor:
Leonore Novak, Maria Petrosino, Daniele Santorelli, Roberta Chiaraluce, Valerio Consalvi, Alessandra Pasquo, Carlo Travaglini-Allocatelli
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5953 (2021)
Bromodomains (BRDs) are small protein interaction modules of about 110 amino acids that selectively recognize acetylated lysine in histones and other proteins. These domains have been identified in a variety of multi-domain proteins involved in trans
Externí odkaz:
https://doaj.org/article/928f6a43d5b34ed1a594a86fde683c64
Autor:
Maria Petrosino, Daniela Bonetti, Alessandra Pasquo, Laura Lori, Roberta Chiaraluce, Valerio Consalvi, Carlo Travaglini-Allocatelli
Publikováno v:
Biochemistry and Biophysics Reports, Vol 11, Iss C, Pp 99-104 (2017)
Bromodomains (BRDs) are small protein domains often present in large multidomain proteins involved in transcriptional regulation in eukaryotic cells. They currently represent valuable targets for the development of inhibitors of aberrant transcriptio
Externí odkaz:
https://doaj.org/article/7301862b8af74c558bcd25801b07fa67
Autor:
Annarita Fiorillo, Maria Petrosino, Andrea Ilari, Alessandra Pasquo, Alessandra Cipollone, Maristella Maggi, Roberta Chiaraluce, Valerio Consalvi
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0199191 (2018)
Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In
Externí odkaz:
https://doaj.org/article/aea6a3fc775d4c81a31610ead4b83318
Autor:
Laura Lori, Alessandra Pasquo, Clorinda Lori, Maria Petrosino, Roberta Chiaraluce, Cynthia Tallant, Stefan Knapp, Valerio Consalvi
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159180 (2016)
Lysine acetylation is an important epigenetic mark regulating gene transcription and chromatin structure. Acetylated lysine residues are specifically recognized by bromodomains, small protein interaction modules that read these modification in a sequ
Externí odkaz:
https://doaj.org/article/5e875bb8a65640469c42b71ff9d1f5c7