Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Alessandra Mascarello"'
Autor:
Hatylas Azevedo, Marcos Ferreira, Alessandra Mascarello, Pavel Osten, Cristiano Ruch Werneck Guimarães
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100226- (2020)
Post-traumatic stress disorder (PTSD) is a mental health condition that is triggered by a stressful event, with symptoms including exaggerated startle response, intrusive traumatic memories and nightmares. The single prolonged stress (SPS) is a multi
Externí odkaz:
https://doaj.org/article/22f80bc8ed28436fbd2e310c21e9f330
Autor:
Rafael M. Couñago, Charles K. Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H. Godoi, Carrow I. Wells, Alessandra Mascarello, Fernando H. de Souza Gama, Katlin B. Massirer, William J. Zuercher, Cristiano R. W. Guimarães, Opher Gileadi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors. However, understanding the cellular role of V
Externí odkaz:
https://doaj.org/article/d22a9c457cc045fe83ff71cae34b8e46
Autor:
Thaís C Muradás, Bruno L Abbadi, Anne D Villela, Fernanda S Macchi, Pedro F Bergo, Talita F de Freitas, Nathalia D M Sperotto, Luis F S M Timmers, Osmar Norberto de Souza, Jaqueline N Picada, Jean Fachini, Juliana Bondan da Silva, Nayara C P de Albuquerque, Maísa D Habenschus, Daniel B Carrão, Bruno A Rocha, Fernando Barbosa Junior, Anderson R M de Oliveira, Alessandra Mascarello, Patrícia Neuenfeldf, Ricardo J Nunes, Héctor R Morbidoni, Maria M Campos, Luiz A Basso, Valnês S Rodrigues-Junior
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202568 (2018)
New effective compounds for tuberculosis treatment are needed. This study evaluated the effects of a series of quinoxaline-derived chalcones against laboratorial strains and clinical isolates of M. tuberculosis. Six molecules, namely N5, N9, N10, N15
Externí odkaz:
https://doaj.org/article/c7d8583f986f47f0b00f0dee6f5f32de
Autor:
CLAUDIA P. FIGUEIREDO, NATALIA C. FERREIRA, GISELLE F. PASSOS, ROBSON DA COSTA, FERNANDA S. NEVES, CLARICE S.C. MACHADO, ALESSANDRA MASCARELLO, LOUISE D. CHIARADIA-DELATORRE, PATRÍCIA D. NEUENFELDT, RICARDO J. NUNES, YRAIMA CORDEIRO
Publikováno v:
Anais da Academia Brasileira de Ciências, Vol 87, Iss 2 suppl, Pp 1421-1434 (2015)
An altered form of the cellular prion protein, the PrPScor PrPRes, is implicated in the occurrence of the still untreatable transmissible spongiform encephalopathies. We have previously synthesized and characterized aromatic compounds that inhibit pr
Externí odkaz:
https://doaj.org/article/7c9d0eadc0b24f0895791b4cc5cc305c
Autor:
Renato Barbosa Camargos, Fabiano José Perina, Daniel Diego Costa Carvalho, Eduardo Alves, Alessandra Mascarello, Louise Domeneghini Chiaradia-Delatorre, Rosendo Augusto Yunes, Ricardo José Nunes, Denilson Ferreira Oliveira
Publikováno v:
Bioscience Journal, Vol 32, Iss 6 (2016)
Alternaria brown spot (ABS), caused by the fungus Alternaria alternata pathotype tangerine, is one of the main phytosanitary problems for mandarin growers. About 15 applications per year of harmful fungicides are required for controlling ABS disease
Externí odkaz:
https://doaj.org/article/59abe956fad54565a6aa112be5027c88
Autor:
Natalia C Ferreira, Icaro A Marques, Wesley A Conceição, Bruno Macedo, Clarice S Machado, Alessandra Mascarello, Louise Domeneghini Chiaradia-Delatorre, Rosendo Augusto Yunes, Ricardo José Nunes, Andrew G Hughson, Lynne D Raymond, Pedro G Pascutti, Byron Caughey, Yraima Cordeiro
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84531 (2014)
The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (P
Externí odkaz:
https://doaj.org/article/43799d36574b4265a3fe221bb978ffb9
Autor:
Alessandra Mascarello, Mattia Mori, Louise Domeneghini Chiaradia-Delatorre, Angela Camila Orbem Menegatti, Franco Delle Monache, Franco Ferrari, Rosendo Augusto Yunes, Ricardo José Nunes, Hernán Terenzi, Bruno Botta, Maurizio Botta
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77081 (2013)
Protein tyrosine phosphatase B (PtpB) is one of the virulence factors secreted into the host cell by Mycobacterium tuberculosis. PtpB attenuates host immune defenses by interfering with signal transduction pathways in macrophages and, therefore, it i
Externí odkaz:
https://doaj.org/article/ec2b24ff543d49f18e8dabad2ffe0a1b
Autor:
Daniela Barretto Barbosa Trivella, Marjorie Christine Paule Bruder, Fábio Cesar Bonafé Oliveira, Renata Porcaro, Joane Kathelen Rustiguel, Leonardo Bergamasco Ribeiro, Rafael de Felicio, Marcos Guilherme da Cunha, Andrey Fabricio Ziem Nascimento, Ana Carolina Mattos Zeri, Lisandra Ravanelli Pessa, Alessandra Mascarello, Cristiano Ruch Werneck Guimarães, Hatylas Azevedo, Marcia Luana Gomes Perfeito, Eduardo Pagani, Cristina Dislich Ropke
Publikováno v:
Revista Fitos. 16:176-192
A descoberta de fármacos a partir de produtos naturais vivencia uma nova era graças ao uso de tecnologias de ponta e abordagens integradas para superar as dificuldades inerentes à pesquisa com produtos naturais. Estes são substâncias químicas a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c9186321077c7fd1862e11dfe1acc6
https://doi.org/10.32712/2446-4775.2022.1346
https://doi.org/10.32712/2446-4775.2022.1346
Autor:
Marcos Ferreira, Natanael D. Segretti, Hatylas Azevedo, Valter Russo, Elisa Russo, Alessandra Mascarello, Cristiano Ruch Werneck Guimarães
Publikováno v:
Journal of Medicinal Chemistry. 64:1904-1929
The modulation of melatonin signaling in peripheral tissues holds promise for treating metabolic diseases like obesity, diabetes, and nonalcoholic steatohepatitis. Here, several benzimidazole derivatives have been identified as novel agonists of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bce5659f5d91fe2c180b3d5a9961956
https://doi.org/10.1021/acs.jmedchem.0c00627
https://doi.org/10.1021/acs.jmedchem.0c00627
Autor:
Alessandra Mascarello, Natália Marceli Stefanes, Louise Domeneghini Chiaradia-Delatorre, Maria Cláudia Santos-Silva, Ricardo José Nunes, Rosendo A. Yunes, Alisson Bigolin, Mariana Franzoni Maioral
Publikováno v:
Chemical Papers. 74:2965-2976
Currently available chemotherapeutic drugs against hematological malignancies have several adverse effects and are associated with high mortality rates. Thus, in this study we evaluated the cytotoxic effect of 26 new sulfonamide derivatives on acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2af41c63fe2c3369e0a494258e64461
https://doi.org/10.1007/s11696-019-00984-7
https://doi.org/10.1007/s11696-019-00984-7