Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alessandra M T, Souza"'
Autor:
Douglas O Escrivani, Rebecca L Charlton, Marjolly B Caruso, Gabriela A Burle-Caldas, Maria Paula G Borsodi, Russolina B Zingali, Natalia Arruda-Costa, Marcos V Palmeira-Mello, Jéssica B de Jesus, Alessandra M T Souza, Bárbara Abrahim-Vieira, Stefanie Freitag-Pohl, Ehmke Pohl, Paul W Denny, Bartira Rossi-Bergmann, Patrick G Steel
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009951 (2021)
With current drug treatments failing due to toxicity, low efficacy and resistance; leishmaniasis is a major global health challenge that desperately needs new validated drug targets. Inspired by activity of the natural chalcone 2',6'-dihydroxy-4'-met
Externí odkaz:
https://doaj.org/article/97dcebeea4914662b9ca60f477d72118
Autor:
Andreza R. Garcia, Danielle M. P. Oliveira, Ana Claudia F. Amaral, Jéssica B. Jesus, Ana Carolina Rennó Sodero, Alessandra M. T. Souza, Claudiu T. Supuran, Alane B. Vermelho, Igor A. Rodrigues, Anderson S. Pinheiro
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1100-1109 (2019)
Inhibition of Leishmania arginase leads to a decrease in parasite growth and infectivity and thus represents an attractive therapeutic strategy. We evaluated the inhibitory potential of selected naturally occurring phenolic substances on Leishmania i
Externí odkaz:
https://doaj.org/article/bac4db29ff844b0db8ebca4f524359e4
Autor:
Andreza R. Garcia, Danielle M. P. Oliveira, Jessica B. Jesus, Alessandra M. T. Souza, Ana Carolina R. Sodero, Alane B. Vermelho, Ivana C. R. Leal, Rodrigo Octavio M. A. Souza, Leandro S. M. Miranda, Anderson S. Pinheiro, Igor A. Rodrigues
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase m
Externí odkaz:
https://doaj.org/article/ff088d1c74a24a95898a1f5b7c0c8a3c
Autor:
Juliana F. R. Mello, Nathália C. Botelho, Alessandra M. T. Souza, Riethe Oliveira, Monique A. Brito, Bárbara de A. Abrahim-Vieira, Ana Carolina R. Sodero, Helena C. Castro, Lucio M. Cabral, Leonardo A. Miceli, Carlos R. Rodrigues
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 10689-10704 (2015)
Herpes simplex virus infections have been described in the medical literature for centuries, yet the the drugs available nowadays for therapy are largely ineffective and low oral bioavailability plays an important role on the inefficacy of the treatm
Externí odkaz:
https://doaj.org/article/4c44b936310b4d6fb14b26f34c18c6d2
Autor:
Leonor L. Leon, Veronica F. Amaral, Marilene M. Canto-Cavalheiro, Carlos R. Rodrigues, Júlio C. Borges, Alessandra M. T. Souza, Cesar D. Oliveira, Helena C. Castro, Marie-Luce F. Lira, Tathiane A. Proux, Karen S. Charret, Alice M. R. Bernardino, Roberta K. F. Marra
Publikováno v:
Molecules, Vol 17, Iss 11, Pp 12961-12973 (2012)
Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments for leishmaniasis due to strain resistance and/or drug side-effects. In this work we repor
Externí odkaz:
https://doaj.org/article/3c2a97f623aa4174b8ed41bf4a0b8386
Autor:
Andreza R, Garcia, Danielle M P, Oliveira, Jessica B, Jesus, Alessandra M T, Souza, Ana Carolina R, Sodero, Alane B, Vermelho, Ivana C R, Leal, Rodrigo Octavio M A, Souza, Leandro S M, Miranda, Anderson S, Pinheiro, Igor A, Rodrigues
Publikováno v:
Frontiers in Chemistry
Arginase catalyzes the hydrolysis of l-arginine into l-ornithine and urea, acting as a key enzyme in the biosynthesis of polyamines. Leishmania growth and survival is dependent on polyamine biosynthesis; therefore, inhibition of Leishmania arginase m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c5f11a131284af07520557a0cbb3b29
https://pubmed.ncbi.nlm.nih.gov/33520939
https://pubmed.ncbi.nlm.nih.gov/33520939