NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin

Autor: Talita D. Melo-Hanchuk, Priscila Ferreira Slepicka, Gabriela Vaz Meirelles, Fernanda Luisa Basei, Diogo Ventura Lovato, Daniela Campos Granato, Bianca Alves Pauletti, Romenia Ramos Domingues, Adriana Franco Paes Leme, Alessandra Luiza Pelegrini, Guido Lenz, Stefan Knapp, Jonathan M. Elkins, Jörg Kobarg

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

Abstract NEK family kinases are serine/threonine kinases that have been functionally implicated in the regulation of the disjunction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and the DNA damage respons

Externí odkaz: https://doaj.org/article/80bf2f9526eb4999bda5f11ee8002f15

The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells

Autor: Matheus Molina Silva, Gabriela Sarti Kinker, Alessandra Luiza Pelegrini, Carlos Frederico Martins Menck, Clarissa Ribeiro Reily Rocha

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports

Lung cancer patients face a dismal prognosis mainly due to the low efficacy of current available treatments. Cisplatin is the first-line chemotherapy treatment for those patients, however, resistance to this drug is a common and yet not fully underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82a35968bc3043dc60c18f4e44333f2
http://link.springer.com/article/10.1038/s41598-019-54065-6

The key role of UVA-light induced oxidative stress in human Xeroderma pigmentosum variant cells

Autor: Camila Corradi, Alessandra Luiza Pelegrini, Clarissa Ribeiro Reily Rocha, Veridiana Munford, Camila Carrião Machado Garcia, Carlos Frederico Martins Menck, Alain Sarasin, Natália Cestari Moreno

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The UVA component of sunlight induces DNA damage, which are basically responsible for skin cancer formation. Xeroderma Pigmentosum Variant (XP-V) patients are defective in the DNA polymerase pol eta that promotes translesion synthesis after sunlight-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff78d26e5d5d2fafb2bd9961572b67e

Boldine: a potential new antiproliferative drug against glioma cell lines

Autor: Christianne Gazzana Salbego, Rudimar Luiz Frozza, Mariana Maier Gaelzer, Andrés Delgado-Cañedo, Ana Paula Horn, Alessandra Luiza Pelegrini, Amélia T. Henriques, Daniéli Gerhardt, Guido Lenz

Publikováno v: Investigational New Drugs. 27:517-525

Malignant gliomas are the most common and devastating primary tumors of the central nervous system. Currently no efficient treatment is available. This study evaluated the effect and underlying mechanisms of boldine, an aporphine alkaloid of Peumus b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd53ad6bcb0d04d79f65bec99b75be41
https://doi.org/10.1007/s10637-008-9203-7

Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest

Autor: Jenifer Saffi, Guido Lenz, Dinara Jaqueline Moura, João Antonio Pêgas Henriques, Gabriela Porto Maques, Alessandra Luiza Pelegrini, Pítia Flores Ledur, Bethânia Luise Brenner

Publikováno v: Mutagenesis. 25(5)

Never in mitosis A (NIMA)-related kinases (Nek) are evolutionarily conserved proteins structurally related to the Aspergillus nidulans mitotic regulator NIMA. Nek1 is one of the 11 isoforms of the Neks identified in mammals. Different lines of eviden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c74732623694812dab8733dfc4f0f50
https://pubmed.ncbi.nlm.nih.gov/20501547