Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alessandra Lo Bianco"'
Autor:
Raffaele Sessa, Silvia Trombetti, Alessandra Lo Bianco, Giovanni Amendola, Rosa Catapano, Elena Cesaro, Fara Petruzziello, Maria D'Armiento, Giuseppe Maria Maruotti, Giuseppe Menna, Paola Izzo, Michela Grosso
Publikováno v:
Open Biology, Vol 14, Iss 2 (2024)
Transient abnormal myelopoiesis (TAM) is a Down syndrome-related pre-leukaemic condition characterized by somatic mutations in the haematopoietic transcription factor GATA-1 that result in exclusive production of its shorter isoform (GATA-1S). Given
Externí odkaz:
https://doaj.org/article/25d54d82a9fd49ac80e2cfb705873602
Autor:
Silvia Trombetti, Raffaele Sessa, Rosa Catapano, Laura Rinaldi, Alessandra Lo Bianco, Antonio Feliciello, Paola Izzo, Michela Grosso
Publikováno v:
Antioxidants, Vol 10, Iss 10, p 1603 (2021)
GATA-1 is a key regulator of hematopoiesis. A balanced ratio of its two isoforms, GATA-1FL and GATA-1S, contributes to normal hematopoiesis, whereas aberrant expression of GATA-1S alters the differentiation/proliferation potential of hematopoietic pr
Externí odkaz:
https://doaj.org/article/2ed306b24c004a5dacdcc526fced7577
Autor:
Angela Corvino, Ida Cerqua, Alessandra Lo Bianco, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elena Morelli, Elisa Perissutti, Vincenzo Santagada, Giuseppe Cirino, Elisabetta Granato, Fiorentina Roviezzo, Elisa Puliti, Caterina Bernacchioni, Antonio Lavecchia, Chiara Donati, Beatrice Severino
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8861 (2021)
S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P1-5). Increasing numbers of studies have indicated the importance of S1P3 in various pathophysiological processes. Recently, we have identified
Externí odkaz:
https://doaj.org/article/59308a81eae347be9c5cb2559c9888a6
Autor:
Silvia Trombetti, Elena Cesaro, Rosa Catapano, Raffaele Sessa, Alessandra Lo Bianco, Paola Izzo, Michela Grosso
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2470 (2021)
Myeloid leukemic cells are intrinsically under oxidative stress due to impaired reactive oxygen species (ROS) homeostasis, a common signature of several hematological malignancies. The present review focuses on the molecular mechanisms of aberrant RO
Externí odkaz:
https://doaj.org/article/3c668cc372f046e3b4bbd4c5638bec8f
Autor:
Angela, Corvino, Ida, Cerqua, Alessandra, Lo Bianco, Giuseppe, Caliendo, Ferdinando, Fiorino, Francesco, Frecentese, Elisa, Magli, Elena, Morelli, Elisa, Perissutti, Vincenzo, Santagada, Giuseppe, Cirino, Elisabetta, Granato, Fiorentina, Roviezzo, Elisa, Puliti, Caterina, Bernacchioni, Antonio, Lavecchia, Chiara, Donati, Beatrice, Severino
Publikováno v:
International Journal of Molecular Sciences
S1P is the final product of sphingolipid metabolism, which interacts with five widely expressed GPCRs (S1P1-5). Increasing numbers of studies have indicated the importance of S1P3 in various pathophysiological processes. Recently, we have identified
Autor:
Kalpana, Tilekar, Jessica D, Hess, Neha, Upadhyay, Alessandra Lo, Bianco, Markus, Schweipert, Antonio, Laghezza, Fulvio, Loiodice, Franz-Josef, Meyer-Almes, Renato J, Aguilera, Antonio, Lavecchia, Ramaa, C S
Publikováno v:
Journal of medicinal chemistry. 64(10)
Monotargeting anticancer agents suffer from resistance and target nonspecificity concerns, which can be tackled with a multitargeting approach. The combined treatment with HDAC inhibitors and PPARγ agonists has displayed potential antitumor effects.
Autor:
Neha Upadhyay, Jessica D. Hess, Antonio Laghezza, Fulvio Loiodice, Alessandra Lo Bianco, Renato J. Aguilera, Franz-Josef Meyer-Almes, Ramaa C S, Kalpana Tilekar, Antonio Lavecchia, Markus Schweipert
Monotargeting anticancer agents suffer from resistance and target nonspecificity concerns, which can be tackled with a multitargeting approach. The combined treatment with HDAC inhibitors and PPARγ agonists has displayed potential antitumor effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5083470342061006c210dfb4216994
http://hdl.handle.net/11588/876044
http://hdl.handle.net/11588/876044
Autor:
Giovanna Speranza, Antonio Lavecchia, Enrica Calleri, Marco Rabuffetti, Marcela Cristina de Moraes, Francesca Rinaldi, Luiz Cláudio Rodrigues Pereira da Silva, Gabriella Massolini, Alessandra Lo Bianco, Daniela Ubiali
Human purine nucleoside phosphorylase (HsPNP) belongs to the purine salvage pathway of nucleic acids. Genetic deficiency of this enzyme triggers apoptosis of activated T-cells due to the accumulation of deoxyguanosine triphosphate (dGTP). Therefore,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae49781474af945f4ec3c9a46ec242b1
http://hdl.handle.net/11588/876046
http://hdl.handle.net/11588/876046
Autor:
Filomena Napolitano, Federica Di Maggio, Francesca Margheri, Alessandra Mocali, Nunzia Mollo, Giuseppina Minopoli, Daniela Sarnataro, Antaripa Bhattacharya, Valeria D'Argenio, Antonella Izzo, Antonio Lavecchia, Alessandra Lo Bianco, Nunzia Montuori, Adriana Limone
Publikováno v:
Journal of Personalized Medicine
Volume 10
Issue 4
Volume 10
Issue 4
Alzheimer&rsquo
s disease (AD) is a fatal neurodegenerative disorder caused by protein misfolding and aggregation, affecting brain function and causing dementia. Amyloid beta (A&beta
), a peptide deriving from amyloid precursor protein (APP
s disease (AD) is a fatal neurodegenerative disorder caused by protein misfolding and aggregation, affecting brain function and causing dementia. Amyloid beta (A&beta
), a peptide deriving from amyloid precursor protein (APP
Autor:
Paola Izzo, Raffaele Sessa, Maria Rosaria Storino, Alessandra Lo Bianco, Michela Grosso, Mariarosaria Giuliano, Rosa Catapano, Silvia Trombetti, Marianna De Martino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69d6577b1f767338bdcea3bb6304ab4b
http://www.intechopen.com/articles/show/title/transcriptional-repressors-of-fetal-globin-genes-as-novel-therapeutic-targets-in-beta-thalassemia
http://www.intechopen.com/articles/show/title/transcriptional-repressors-of-fetal-globin-genes-as-novel-therapeutic-targets-in-beta-thalassemia