Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alessandra Livraghi-Butrico"'
Autor:
Weining Yin, Hannah L. Golliher, Amy J. Ferguson, Julia S. Kimbell, Alessandra Livraghi-Butrico, Troy D. Rogers, Barbara R. Grubb, Adam J. Kimple, Lawrence E. Ostrowski
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Background: Genetic defects in motile cilia cause primary ciliary dyskinesia (PCD), a rare disease with no specific therapeutics. Individuals with PCD often have impaired fertility and laterality defects and universally suffer from upper and lower ai
Externí odkaz:
https://doaj.org/article/7313cb29e11040f7ab3ac56f34fb3ca2
Autor:
Troy D. Rogers, Brian Button, Samir N. P. Kelada, Lawrence E. Ostrowski, Alessandra Livraghi-Butrico, Mark I. Gutay, Charles R. Esther, Barbara R. Grubb
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must be removed to keep the lower airways sterile. Thus, one might expect v
Externí odkaz:
https://doaj.org/article/8f11df437d0b4e6cbc966594a58fd2c5
Autor:
Jie Xu, Alessandra Livraghi-Butrico, Xia Hou, Carthic Rajagopalan, Jifeng Zhang, Jun Song, Hong Jiang, Hong-Guang Wei, Hui Wang, Mohamad Bouhamdan, Jinxue Ruan, Dongshan Yang, Yining Qiu, Youming Xie, Ronald Barrett, Sharon McClellan, Hongmei Mou, Qingtian Wu, Xuequn Chen, Troy D. Rogers, Kristen J. Wilkinson, Rodney C. Gilmore, Charles R. Esther Jr., Khalequz Zaman, Xiubin Liang, Michael Sobolic, Linda Hazlett, Kezhong Zhang, Raymond A. Frizzell, Martina Gentzsch, Wanda K. O’Neal, Barbara R. Grubb, Y. Eugene Chen, Richard C. Boucher, Fei Sun
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of
Externí odkaz:
https://doaj.org/article/ff264f8cd5104415abd1eba07591062e
Autor:
Gregg A. Duncan, Namho Kim, Yanerys Colon-Cortes, Jason Rodriguez, Marina Mazur, Susan E. Birket, Steven M. Rowe, Natalie E. West, Alessandra Livraghi-Butrico, Richard C. Boucher, Justin Hanes, George Aslanidi, Jung Soo Suk
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 296-304 (2018)
Diffusion of the viral vectors evaluated in inhaled gene therapy clinical trials to date are largely hindered within airway mucus, which limits their access to, and transduction of, the underlying airway epithelium prior to clearance from the lung. H
Externí odkaz:
https://doaj.org/article/5332708677764322aae6c72388bddfc5
Autor:
Barbara Sipione, Nicola Ivan Lorè, Francesca Sanvito, Giacomo Rossi, Alessia Neri, Fabrizio Gianferro, Anna Sofia Tascini, Alessandra Livraghi-Butrico, Cristina Cigana, Alessandra Bragonzi
Mutations ofCystic Fibrosis Transmembrane conductance Regulator(CFTR) lead to Cystic Fibrosis (CF), but the substantial phenotypic variations are determined by non-CFTRallelic diversity. To map novel disease phenotypes in a CF mouse model, we used Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::689a92dc1a2284866fbd9ea3ec1e643c
https://doi.org/10.1101/2023.01.31.526098
https://doi.org/10.1101/2023.01.31.526098
Autor:
Nikhil Pandey, Valentina Simon, Marina Mazur, Gijung Kwak, Richard C. Boucher, Siddharth Kaup Shenoy, Eric Han, Namho Kim, Susan E Birket, Jason Rodriguez, Jung Soo Suk, Steven M. Rowe, Justin Hanes, Anthony J. Kim, Xinyuan Zuo, Alessandra Livraghi-Butrico
Publikováno v:
Thorax
IntroductionInhaled gene therapy of muco-obstructive lung diseases requires a strategy to achieve therapeutically relevant gene transfer to airway epithelium covered by particularly dehydrated and condensed mucus gel layer. Here, we introduce a synth
Publikováno v:
Curr Opin Pharmacol
Few human genetic diseases can rely on the availability of as many and as diverse animal models as cystic fibrosis (CF), a multiorgan syndrome caused by functional absence of cystic fibrosis transmembrane regulator (CFTR). The recent development of h
Publikováno v:
European Respiratory Journal. 60:2200832
Autor:
Scott B. Biering, Sylvia A. Sarnik, Eleanor Wang, James R. Zengel, Sarah R. Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R. Jangid, Connor V. Duffy, Jin Wei, Rodney C. Gilmore, Mia Madel Alfajaro, Madison S. Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H. Yamashiro, Julia A. Belk, Adam Begeman, Jessica C. Stark, D. Judy Shon, Douglas M. Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S. Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R. Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C. Aguilar, Andreas S. Puschnik, Brian Button, Benjamin A. Pinsky, Catherine A. Blish, Ralph S. Baric, Wanda K. O’Neal, Carolyn R. Bertozzi, Craig B. Wilen, Richard C. Boucher, Jan E. Carette, Sarah A. Stanley, Eva Harris, Silvana Konermann, Patrick D. Hsu
Publikováno v:
Nature genetics, vol 54, iss 8
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infect
Autor:
Troy D. Rogers, Weining Yin, Alessandra Livraghi-Butrico, Lawrence E. Ostrowski, Kimberlie A. Burns, Barbara R. Grubb, Patrick R. Sears
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 61:312-321
Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disease caused by mutations in over 40 different genes. Individuals with PCD caused by mutations in RSPH1 (radial ...