3,4-Dihydroquinoxalin-2-one privileged motif: A journey from classical chiral tools based synthesis to modern catalytic enantioselective strategies

Autor: Alessandra Lattanzi

Publikováno v: Tetrahedron Chem, Vol 3, Iss , Pp 100027- (2022)

Optically pure 3,4-dihydroquinoxalin-2-ones, being members of the privileged quinoxaline family, received significant interest in organic synthesis, more particularly in medicinal chemistry, proving also to be useful building blocks for facile entry

Externí odkaz: https://doaj.org/article/c8ee9ad1f9b24a5c94e6ed63b906fbf4

Cover Picture: From Three‐ to Six‐Membered Heterocycles Bearing a Quaternary Stereocenter: an Asymmetric Organocatalytic Approach (Chem. Rec. 5/2023)

Autor: Alessandra Lattanzi

Publikováno v: The Chemical Record. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd6755287144ddca33a893cea0fef69c
https://doi.org/10.1002/tcr.202380501

Epoxides: Small Rings to Play with under Asymmetric Organocatalysis

Autor: Sara Meninno, Alessandra Lattanzi

Publikováno v: ACS Organic & Inorganic Au. 2:289-305

Optically pure epoxides are recognized as highly valuable products and key intermediates, useful in different areas from pharmaceutical and agrochemical industries to natural product synthesis and materials science. The predictable fate of the ring-o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49851513aef7064ad4b78f5f691c05d9
https://doi.org/10.1021/acsorginorgau.2c00009

Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: a Telescoped Approach

Autor: Sara Meninno, Alessandra Puglisi, Alessandra Lattanzi, Maurizio Benaglia, Francesca Franco

Publikováno v: The Journal of Organic Chemistry

A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and N-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75116ea069d4ab879773aa6ac879276
https://doi.org/10.1021/acs.joc.1c01270

Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter

Autor: Francesca Franco, Sara Meninno, Jacob Overgaard, Sergio Rossi, Maurizio Benaglia, Alessandra Lattanzi

Publikováno v: Franco, F, Meninno, S, Overgaard, J, Rossi, S, Benaglia, M & Lattanzi, A 2022, ' Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter ', Organic Letters, vol. 24, no. 24, pp. 4371-4376 . https://doi.org/10.1021/acs.orglett.2c01589

A highly enantioselective one-pot synthesis of functionalized triflones, bearing a quaternary stereocenter, has been developed, exploiting the Michael reaction of α-(trifluoromethylsulfonyl) aryl acetic acid esters with N-acryloyl-1H-pyrazole cataly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4759da4fc540eed2cbe5b794a09af3
http://hdl.handle.net/2434/933372