Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alessandra Cirla"'
Autor:
Alessandra Cirla, Elena Casale, Nilla Avanzi, Marina Ciomei, Viviana Desperati, Helena Posteri, Eduard R. Felder, Gianluca Papeo, Alessia Montagnoli, Arturo Galvani, Marco Guanci, Daniela Borghi, Antonella Isacchi, Daniele Donati, Sonia Rainoldi, Alessandra Scolaro, Paolo Orsini, Federico Riccardi-Sirtori
Publikováno v:
ACS Medicinal Chemistry Letters. 10:534-538
[Image: see text] Poly(ADP-ribose) polymerase-1 (PARP-1) is an enzyme involved in signaling and repair of DNA single strand breaks. PARP-1 employs NAD(+) to modify substrate proteins via the attachment of poly(ADP-ribose) chains. PARP-1 is a well est
Autor:
Arturo Galvani, Daniele Donati, Emiliana Corti, Alessandra Cirla, Paolo Orsini, Elena Casale, Francesco Sola, Mikhail Krasavin, Marina Fasolini, Enrico Pesenti, Barbara Forte, Rita Perego, Antonella Isacchi, Alina Busel, Daniela Borghi, Alessia Montagnoli, Fabio Zuccotto, Federico Riccardi-Sirtori, Eduard R. Felder, Helena Posteri, Rosita Lupi, Alexander Viktorovich Khvat, Marina Ciomei, Daniele Pezzetta, Gianluca Papeo, Matteo D'anello, Sonia Rainoldi, Francesco Caprera, Alessandra Scolaro
Publikováno v:
Journal of Medicinal Chemistry. 58:6875-6898
The nuclear protein poly(ADP-ribose) polymerase-1 (PARP-1) has a well-established role in the signaling and repair of DNA and is a prominent target in oncology, as testified by the number of candidates in clinical testing that unselectively target bo
Autor:
Christian Orrenius, Arturo Galvani, Peter K. Jackson, Paola Magnaghi, Mauro Angiolini, Steven Magnuson, Thomas O'Brien, Liviana Cozzi, Daniele Donati, Nuvoloni Stefano, Alessandra Badari, Elena Casale, Simona Rizzi, Nilla Avanzi, Laura Riceputi, Federico Riccardi Sirtori, Roberto D'Alessio, Yichin Liu, Alessandra Cirla, Silvia Cauteruccio, Beatrice Trucchi, Antonella Isacchi, Paolo Polucci, Daniela Asa, J.A. Bertrand, Malgesini Ms Beatrice
Publikováno v:
Journal of Medicinal Chemistry. 56:437-450
Valosine containing protein (VCP), also known as p97, is a member of AAA ATPase family that is involved in several biological processes and plays a central role in the ubiquitin-mediated degradation of misfolded proteins. VCP is an ubiquitously expre
Autor:
Elena Ardini, Dario Ballinari, Eduard R. Felder, Alessandra Cirla, Paolo Polucci, Arturo Galvani, Patrizia Banfi, Antonella Isacchi, Ilaria Motto, Daniele Donati, Cinzia Cristiani, Nilla Avanzi, Andrea Lombardi Borgia, Maria Menichincheri, Matteo D'anello, Marina Ciomei
Publikováno v:
Cancer Research. 78:4785-4785
RET chromosomal rearrangements initially identified in a subset of papillary thyroid cancers, as well as gain-of-function point mutations present in ca. 70% of medullary thyroid carcinomas, are well established as oncogenic events that induce constit
Autor:
Nilla Avanzi, Fabio Gasparri, Roberto D'Alessio, Barbara Salom, Graziella Sorrentino, Liviana Cozzi, Antonio Lomolino, Daniele Donati, Michele Caruso, Arturo Galvani, Steven Magnuson, Thomas O'Brien, Alessandra Cirla, Daniela Borghi, Antonella Isacchi, Daniela Asa, Ilaria Motto, Alessandra Badari, Barbara Valsasina, Simona Rizzi, Paola Magnaghi, Maurizio Pasi, Giovanni Cervi, Beatrice Malgesini, Eduard R. Felder, Sonia Troiani
Publikováno v:
Journal of medicinal chemistry. 57(24)
Valosine-containing protein (VCP), also known as p97 or cdc48 in yeast, is a highly abundant protein belonging to the AAA ATPase family involved in a number of essential cellular functions, including ubiquitin–proteasome mediated protein degradatio
Publikováno v:
Tetrahedron. 60:4019-4029
The work presents a synthetic route to the CD ring of calicheamicin and in the case of neocarzinostatin an approach to a functionalised cyclopentane-1,3-diol containing the naturally occurring naphthoate and a glucosamine motif. In the case of the NC
Autor:
Giulia Canevari, Elena Casale, Nilla Avanzi, Elena Ardini, Arturo Galvani, Nadia Amboldi, Antonella Ermoli, Daniele Donati, Dario Ballinari, Sonia Troiani, Cinzia Cristiani, Alessandra Cirla, Paolo Polucci, Federico Riccardi Sirtori, Marina Ciomei, Eduard R. Felder, Patrizia Banfi, Antonella Isacchi, Ilaria Motto, Maria Menichincheri, Francesco Caprera
Publikováno v:
Cancer Research. 77:2082-2082
RET, a receptor tyrosine kinase (RTK) expressed mainly in neural crest-derived tissues, plays a role in cell growth and differentiation and its physiological activation depends upon binding to the GDNF family. Genetic aberrations leading to constitut
Autor:
Nilla Avanzi, Sabrina Cribioli, Paola Gnocchi, Jay Bertrand, Danilo Mirizzi, Daniele Casero, Arturo Galvani, Paola Vianello, Maristella Colombo, Eduard R. Felder, Gabriele Fachin, Achille Panzeri, Lucio Ceriani, G. Canevari, Franco Della Vedova, Dario Ballinari, Cinzia Cristiani, Enrico Pesenti, Marcella Nesi, Tiziano Bandiera, Marina Ciomei, Alessandra Cirla, Maria Gabriella Brasca, Antonella Isacchi, Daniele Donati, Ilaria Motto, Simona Bindi, Marina Fasolini, Davide Carenzi
Publikováno v:
Bioorganicmedicinal chemistry. 22(17)
We report herein the discovery, structure guided design, synthesis and biological evaluation of a novel class of JAK2 inhibitors. Optimization of the series led to the identification of the potent and orally bioavailable JAK2 inhibitor 28 (NMS-P953).
Publikováno v:
Expert opinion on therapeutic patents. 23(4)
Inhibitors of the poly(ADP-ribose) polymerases (PARPs) family of proteins are currently being evaluated as potential anticancer medicines at both preclinical and clinical levels. They have the peculiarity to increase the efficacy of DNA-damaging agen
Autor:
Marco Tato, Paolo Orsini, Ermes Vanotti, Francesco Fiorentini, Arturo Galvani, Valter Croci, Fabrizio Orzi, Cristina Alli, Jurgen Moll, Maristella Colombo, Roberto D'Alessio, Alberto Bargiotti, Barbara Forte, Enrico Pesenti, Katia Martina, Clara Albanese, Matteo D'anello, Barbara Valsasina, Mario Varasi, Patrizia Giordano, Antonella Isacchi, Alessandra Cirla, Marcellino Tibolla, Antonio Pillan, Antonella Ciavolella, Alessandra Scolaro, Paola Vianello, Fulvia Roletto, Antonella Ermoli, Antonio Molinari, Daniele Volpi, Alessia Montagnoli, Corrado Santocanale, Maria Menichincheri, Francesco Colotta, Dario Ballinari, Marina Caldarelli
Publikováno v:
Journal of medicinal chemistry. 53(20)
Cdc7 serine/threonine kinase is a key regulator of DNA synthesis in eukaryotic organisms. Cdc7 inhibition through siRNA or prototype small molecules causes p53 independent apoptosis in tumor cells while reversibly arresting cell cycle progression in