Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Alessandra Castaldi"'
Autor:
Minxiao Yang, Hua Shen, Per Flodby, Michael D. Koss, Rania Bassiouni, Yixin Liu, Tea Jashashvili, Aaron Neely, Ezuka Ogbolu, Jonathan Castillo, Theresa Ryan Stueve, Daniel J. Mullen, Amy L. Ryan, John Carpten, Alessandra Castaldi, W. Dean Wallace, Beiyun Zhou, Zea Borok, Crystal N. Marconett
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113286- (2023)
Summary: Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer and presents clinically with a high degree of biological heterogeneity and distinct clinical outcomes. The current paradigm of LUAD etiology posits alveolar epithelial t
Externí odkaz:
https://doaj.org/article/6bee7a1ea43041919b5b99f6a8863aa1
Autor:
Judd C. Rice, Benjamin H. Weekley, Tomas Kanholm, Zhihui Chen, Sunyoung Lee, Daniel J. Fernandez, Rachel Abrahamson, Alessandra Castaldi, Zea Borok, Brian D. Dynlacht, Woojin An
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Background Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of the genome. Although i
Externí odkaz:
https://doaj.org/article/693bd8e673be46a79c89da26efca485f
Autor:
Pooja Hor, Vasu Punj, Ben A. Calvert, Alessandra Castaldi, Alyssa J. Miller, Gianni Carraro, Barry R. Stripp, Steven L. Brody, Jason R. Spence, Justin K. Ichida, Amy L. Ryan (Firth), Zea Borok
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Expansion of pulmonary neuroendocrine cells (PNECs) is a pathological feature of many human lung diseases. Human PNECs are inherently difficult to study due to their rarity (
Externí odkaz:
https://doaj.org/article/3b48a752bd614d27a8fbdb9eff4eef14
Autor:
Michele Miragoli, Jose L. Sanchez-Alonso, Anamika Bhargava, Peter T. Wright, Markus Sikkel, Sophie Schobesberger, Ivan Diakonov, Pavel Novak, Alessandra Castaldi, Paola Cattaneo, Alexander R. Lyon, Max J. Lab, Julia Gorelik
Publikováno v:
Cell Reports, Vol 14, Iss 1, Pp 140-151 (2016)
Arrhythmogenesis during heart failure is a major clinical problem. Regional electrical gradients produce arrhythmias, and cellular ionic transmembrane gradients are its originators. We investigated whether the nanoscale mechanosensitive properties of
Externí odkaz:
https://doaj.org/article/1d635e6cbdab41fab11e7f366de7d465
Autor:
Masafumi Horie, Alessandra Castaldi, Mitsuhiro Sunohara, Hongjun Wang, Yanbin Ji, Yixin Liu, Fan Li, Thomas A. Wilkinson, Long Hung, Hua Shen, Hidenori Kage, Ite A. Offringa, Crystal N. Marconett, Per Flodby, Beiyun Zhou, Zea Borok
Publikováno v:
Cells, Vol 9, Iss 11, p 2460 (2020)
Molecular and functional characterization of alveolar epithelial type I (AT1) cells has been challenging due to difficulty in isolating sufficient numbers of viable cells. Here we performed single-cell RNA-sequencing (scRNA-seq) of tdTomato+ cells fr
Externí odkaz:
https://doaj.org/article/ce2fcf11018c4b0d9564c1d239275256
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 12, p 4370 (2020)
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance between ROS and antioxidants contributes substantially to the physiological welfare of the cell. During pathological conditions, an altered redox equilibrium le
Externí odkaz:
https://doaj.org/article/ca0ce0fce8434516852cbc9486ab44df
Autor:
Minxiao Yang, Hua Shen, Per Flodby, Michael D. Koss, Rania Bassiouni, Yixin Liu, Tea Jashashvili, Theresa R. Stueve, Daniel J. Mullen, Amy L. Ryan, John Carpten, Alessandra Castaldi, W. Dean Wallace, Beiyun Zhou, Zea Borok, Crystal N. Marconett
Lung adenocarcinoma (LUAD) is the most common subtype of cancer arising in the distal lung. LUAD encompasses several pathologic subtypes, each with differing clinical outcomes and biological behaviors. However, the molecular and cellular underpinning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00cfefb98b35cc7a417ba940fcdb1eb0
https://doi.org/10.1101/2022.10.29.514334
https://doi.org/10.1101/2022.10.29.514334
Autor:
Beiyun Zhou, Zea Borok, Crystal N. Marconett, Megan E. Rieger, Kusum Pandit, Ite A. Offringa, Alessandra Castaldi, Masafumi Horie, Mitsuhiro Sunohara, Mickael Dubourd
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and type 2 (AT2) cells, the latter being capable of self-renewal and transdifferentiation into AT1 cells for normal maintenance and restoration of epithelial int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4413abcc5da453a0119a5ac7f2e94706
https://doi.org/10.1152/ajplung.00519.2019
https://doi.org/10.1152/ajplung.00519.2019
Autor:
Per Flodby, W. Pinson-Rose, H. Shen, K. Samimi, Y. Ji, K. Solaimanpour, Parviz Minoo, Beiyun Zhou, Zea Borok, Alessandra Castaldi, Yixin Liu, P. Zamani, A. Allen, Masafumi Horie
Publikováno v:
A10. A010 NOVEL DISCOVERIES IN LUNG BIOLOGY.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d4ee79516cc6b2510f2eeccfcb5e059
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1044
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1044