Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Alessandra Brancalion"'
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Akademický článek
Protein kinase CK2 inhibition down modulates the NF-κB and STAT3 survival pathways, enhances the cellular proteotoxic stress and synergistically boosts the cytotoxic effect of bortezomib on multiple myeloma and mantle cell lymphoma cells.
Autor: Sabrina Manni, Alessandra Brancalion, Elisa Mandato, Laura Quotti Tubi, Anna Colpo, Marco Pizzi, Rocco Cappellesso, Fortunato Zaffino, Speranza Antonia Di Maggio, Anna Cabrelle, Filippo Marino, Renato Zambello, Livio Trentin, Fausto Adami, Carmela Gurrieri, Gianpietro Semenzato, Francesco Piazza
Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75280 (2013)
CK2 is a pivotal pro-survival protein kinase in multiple myeloma that may likely impinge on bortezomib-regulated cellular pathways. In the present study, we investigated CK2 expression in multiple myeloma and mantle cell lymphoma, two bortezomib-resp
Externí odkaz: https://doaj.org/article/cf880ea560674539820be889a1f12b9a
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9
Protein kinase CK2 regulates AKT, NF-κB and STAT3 activation, stem cell viability and proliferation in acute myeloid leukemia
Autor: Carmela Gurrieri, Alessandra Brancalion, Marilena Carrino, Elisa Mandato, Gianpietro Semenzato, L Quotti Tubi, Fortunato Zaffino, Livio Trentin, Francesco Piazza, Gianni Binotto, Paolo Macaccaro, Sabrina Manni, Ketty Gianesin, E Doriguzzi Breatta, S Canovas Nunes, Renato Zambello
Publikováno v: Europe PubMed Central
Protein kinase CK2 sustains acute myeloid leukemia cell growth, but its role in leukemia stem cells is largely unknown. Here, we discovered that the CK2 catalytic α and regulatory β subunits are consistently expressed in leukemia stem cells isolate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a4ca9c0df13a9373ebe217340b48e
http://hdl.handle.net/11577/3206932
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