Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alessandra Bonito-Oliva"'
Autor:
Angelina S. Bortoletto, W. Vallen Graham, Gabriella Trout, Alessandra Bonito‐Oliva, Manija A. Kazmi, Jing Gong, Emily Weyburne, Brandy L. Houser, Thomas P. Sakmar, Ronald J. Parchem
Publikováno v:
Advanced Science, Vol 9, Iss 34, Pp n/a-n/a (2022)
Abstract Type 2 diabetes mellitus (T2D) is a major public health concern and is characterized by sustained hyperglycemia due to insulin resistance and destruction of insulin‐producing β cells. One pathological hallmark of T2D is the toxic accumula
Externí odkaz:
https://doaj.org/article/fc13ca5e48c84fccafa8805eefa0fd48
Autor:
Anastasia Falconi, Alessandra Bonito-Oliva, Martina Di Bartolomeo, Marcella Massimini, Francesco Fattapposta, Nicoletta Locuratolo, Enrico Dainese, Esterina Pascale, Gilberto Fisone, Claudio D’Addario
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Adenosine A2A receptors (A2ARs) have attracted considerable attention as an important molecular target for the design of Parkinson’s disease (PD) therapeutic compounds. Here, we studied the transcriptional regulation of the A2AR gene in human perip
Externí odkaz:
https://doaj.org/article/1e02d40f6d3e42b79cccae32927b9e76
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Non-motor symptoms, including cognitive deficits and affective disorders, are frequently diagnosed in Parkinson’s disease (PD) patients and are only partially alleviated by dopamine replacement therapy. Here, we used a 6-hydroxydopamine (6-OHDA) mo
Externí odkaz:
https://doaj.org/article/8ec60a1018384b699e964a83b591fe92
Autor:
Giuseppe Gangarossa, Manuela Di Benedetto, Gerard J O'Sullivan, Mark Dunleavy, Cristina Alcacer, Alessandra Bonito-Oliva, David C Henshall, John L Waddington, Emmanuel Valjent, Gilberto Fisone
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19415 (2011)
Activation of dopamine D1 receptors (D1Rs) has been shown to induce epileptiform activity. We studied the molecular changes occurring in the hippocampus in response to the administration of the D1-type receptor agonist, SKF 81297. SKF 81297 at 2.5 an
Externí odkaz:
https://doaj.org/article/95e3be8cc9ac47d28e87e8c24bdc3283
Autor:
Andrew C. Toader, Josue M. Regalado, Yan Ran Li, Andrea Terceros, Nakul Yadav, Suraj Kumar, Sloane Satow, Florian Hollunder, Alessandra Bonito-Oliva, Priya Rajasethupathy
Publikováno v:
Cell. 186:1369-1381.e17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1312b4181e6997493618d0f3bc57e234
https://doi.org/10.1016/j.cell.2023.02.024
https://doi.org/10.1016/j.cell.2023.02.024
Autor:
Oliver Stiedl, Sven Ove Ögren, Alessandra Bonito-Oliva, Abdu Adem, Gilberto Fisone, Nather Madjid, Sarah Holst, Åsa Konradsson-Geuken
Publikováno v:
European Neuropsychopharmacology. 29:616-628
Schizophrenia is associated with cognitive impairments related to hypofunction in glutamatergic N-methyl- D -aspartate receptor (NMDAR) transmission. Phencyclidine (PCP), a non-competitive NMDAR antagonist, models schizophrenia-like behavioral sympto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410bf5c42e7b268eedc5ce54e694112e
https://doi.org/10.1016/j.euroneuro.2019.03.007
https://doi.org/10.1016/j.euroneuro.2019.03.007
Publikováno v:
Annual Review of Medicine. 68:413-430
Alzheimer's disease (AD) is the primary cause of age-related dementia. Effective strategies to prevent and treat AD remain elusive despite major efforts to understand its basic biology and clinical pathophysiology. Significant investments in therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::888f73e5e8ba1e54707e4d504a3ff7d2
https://doi.org/10.1146/annurev-med-042915-103753
https://doi.org/10.1146/annurev-med-042915-103753
Autor:
Vallen Graham W, Deguzman J, Kim Marquette, Caroline Graff, Riyez Karim, Petro M, Thomas P. Sakmar, Rita Agostinelli, Kerry Kelleher, Lioudmila Tchistiakova, Alessandra Bonito-Oliva, Anna-Karin Lindström, Paul D. Wes, Wood Km
The hypothesis that amyloid beta peptides (Aβ) are central to the pathogenesis of sporadic Alzheimer’s disease (AD) is still hotly debated. Although several monoclonal antibodies (mAbs) against Aβ have failed in therapeutic clinical trials, two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b14dd81363a25c2bfaae8ff3a9016ed
Autor:
Marcella Massimini, Alessandra Bonito-Oliva, Anastasia Falconi, Martina Di Bartolomeo, Claudio D'Addario, Esterina Pascale, Francesco Fattapposta, Nicoletta Locuratolo, Gilberto Fisone, Enrico Dainese
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
Frontiers in Neuroscience
Frontiers in Neuroscience
Adenosine A2A receptors (A2ARs) have attracted considerable attention as an important molecular target for the design of Parkinson’s disease (PD) therapeutic compounds. Here, we studied the transcriptional regulation of the A2AR gene in human perip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71d809ce54d9531b7ccc814150eb944
http://hdl.handle.net/11575/105834
http://hdl.handle.net/11575/105834
Autor:
Erik Södersten, Xiaochen Hu, Arash Hellysaz, Giada Spigolon, Gilberto Fisone, Alessandra Bonito-Oliva, Christian Broberger, Ana Luisa Rodrigues Gomes, Klaus Hansen, Anastasia Falconi
Publikováno v:
Neuropharmacology. 107:89-99
Phosphorylation of histone H3 (H3) on serine 28 (S28) at genomic regions marked by trimethylation of lysine 27 (H3K27me3) often correlates with increased expression of genes normally repressed by Polycomb group proteins (PcG). We show that amphetamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b4b7a178e49edae8c25e0a118655e7
https://doi.org/10.1016/j.neuropharm.2016.02.037
https://doi.org/10.1016/j.neuropharm.2016.02.037