Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alessandra, Pasquarello"'
Autor:
Laurie J. Gordon, Anna-Maria Capelli, Laura Zonzini, Manuela Borriello, Romano Di-Fabio, Enrica Granci, Massimo Gianotti, Roberto Arban, Simone Spada, Barbara Bertani, Stefania Faedo, Valeria Zucchelli, Alessandra Pasquarello, Angela Worby, Steven Mark Bromidge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7092-7096
5-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}-2(1H)-quinolinones and 3,4-dihydro-2(1H)-quinolinones have been identified with different combinations of 5-HT(1) autoreceptor antagonist and hSerT potencies and excellent rat PK profiles. The avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9b2fdf2549f8ba8e5757ce71776585
https://doi.org/10.1016/j.bmcl.2010.09.085
https://doi.org/10.1016/j.bmcl.2010.09.085
Autor:
Alessandra Pasquarello, Luca Tarsi, Federica Tonelli, Romano Di Fabio, Roberto Arban, Fabrizio Micheli, Gabriella Gentile, Federica Bianchi, Susanna Cremonesi, Alberto Buson, Silvia Terreni, Alfonso Pozzan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5044-5049
Novel series of pyrrole-pyrazinone and pyrazole-pyrazinone have been identified as potent and selective Vasopressin1b receptor antagonists. Exploration of the substitution pattern around the core of these templates allowed generation of compounds wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3376c4b966ce7ae383b0eabc8a28a9
https://doi.org/10.1016/j.bmcl.2010.07.037
https://doi.org/10.1016/j.bmcl.2010.07.037
Autor:
Ilaria Sartori, Laura Zonzini, Laurie J. Gordon, Angela Worby, Stefano Fontana, Manuela Borriello, Silvia Bison, Jeannette M. Watson, Steven Mark Bromidge, Giovanna Dal Forno, Colin Philip Leslie, Alessandra Pasquarello, Anna Sava, Luca G. Moccia, Barbara Bertani, Roberto Arban, Daniele Donati, Enrica Granci, Valeria Zucchelli, Paolo Cavanni, Massimo Gianotti, Romano Di-Fabio
Publikováno v:
Journal of Medicinal Chemistry. 53:5827-5843
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT1A/B/D receptor antagonists with and wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2fb74da943dfb46e7a247dd0b3079e2
https://doi.org/10.1021/jm100482n
https://doi.org/10.1021/jm100482n
Autor:
Albert A. Jaxa-Chamiec, Daniele Donati, Silvia Davalli, Fabrizio Micheli, Marilisa Rinaldi, Giorgio Bonanomi, Giovanna Tedesco, Chiara Gallotti, Martyn D. Wood, Silvia Terreni, Marcella Petrone, Graham J. Riley, Federica Damiani, Dieter Hamprecht, Alessandra Pasquarello, Anna Checchia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3906-3912
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT 2C receptor antagonists and the discovery of a new class of potent and selective 5-HT 2C molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ba772e4f2408b566e0d2feffaaa17
https://doi.org/10.1016/j.bmcl.2006.05.034
https://doi.org/10.1016/j.bmcl.2006.05.034
Autor:
Daniela Arosio, Fabrizio Micheli, Leonardo Manzoni, Anna Bernardi, Pierfausto Seneci, and Alessandra Pasquarello
Publikováno v:
The Journal of Organic Chemistry. 66:6209-6216
The practical, stereoselective synthesis of the three diastereoisomeric 1,2-trans-dicarboxy-4,5-cyclohexanediols 1-3 (DCCHDs) is described, starting from a common precursor, easily available in both enantiomeric forms. The regioselective derivatizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59eedaa37cccf4bf7c7f1744c0185e3a
https://doi.org/10.1021/jo015570b
https://doi.org/10.1021/jo015570b
Autor:
Beatrice Oliosi, Gianluca Araldi, S. Polinelli, Giorgio Tarzia, Alessandra Pasquarello, Ftm van Amsterdam, Daniele Donati, A. Ursini
Publikováno v:
European Journal of Medicinal Chemistry. 31:215-220
Summary This paper describes the synthesis of novel derivatives 4a–i, which are structurally related to PD134308 and in which the indole moiety is replaced by other aromatic groups. Cholecystokinin-A and -B (CCK-A and CCK-B) receptor binding affini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa0545d4c138550c5c6efc8c8bd5938
https://doi.org/10.1016/0223-5234(96)89137-9
https://doi.org/10.1016/0223-5234(96)89137-9
Publikováno v:
ChemInform. 22
The hydrogenation of 3-methyl-fumaric and maleic ester mono aldehydes protected as oxazolidines of nor-ephedrine (NEPH) derivation has been studied. This transformation takes place with moderate to good π-face stereodifferentiation and allows the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::622ef45d33d560828ec1f3d9a95b9fdf
https://doi.org/10.1002/chin.199151076
https://doi.org/10.1002/chin.199151076
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45be1715246ff7946927d75b09323749
https://doi.org/10.1002/chin.199233070
https://doi.org/10.1002/chin.199233070
Autor:
Alessandra Pasquarello, Gianluca Araldi, Daniele Donati, F. T. M. Van Amsterdam, Beatrice Oliosi, S. Polinelli, Giorgio Tarzia, A. Ursini
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2417d25d852edc2516c1388060f9a87
https://doi.org/10.1002/chin.199627221
https://doi.org/10.1002/chin.199627221
Autor:
Steven M, Bromidge, Roberto, Arban, Barbara, Bertani, Silvia, Bison, Manuela, Borriello, Paolo, Cavanni, Giovanna, Dal Forno, Romano, Di-Fabio, Daniele, Donati, Stefano, Fontana, Massimo, Gianotti, Laurie J, Gordon, Enrica, Granci, Colin P, Leslie, Luca, Moccia, Alessandra, Pasquarello, Ilaria, Sartori, Anna, Sava, Jeannette M, Watson, Angela, Worby, Laura, Zonzini, Valeria, Zucchelli
Publikováno v:
Journal of medicinal chemistry. 53(15)
Bioisoteric replacement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small heterocyclic rings has led to novel series of fused tricyclic benzoxazines which are potent 5-HT(1A/B/D) receptor antagonists with and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db3e73771267ce95dfc8d88c85ab0a7e
https://pubmed.ncbi.nlm.nih.gov/20590088
https://pubmed.ncbi.nlm.nih.gov/20590088