Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Alessandra, Biasiolo"'
Autor:
Gianmarco Villano, Erica Novo, Cristian Turato, Santina Quarta, Mariagrazia Ruvoletto, Alessandra Biasiolo, Francesca Protopapa, Monica Chinellato, Andrea Martini, Elisabetta Trevellin, Marnie Granzotto, Stefania Cannito, Laura Cendron, Silvia De Siervi, Maria Guido, Maurizio Parola, Roberto Vettor, Patrizia Pontisso
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101889- (2024)
Objective: The serine protease inhibitor SerpinB3 has been described as critical mediator of liver fibrosis and it has been recently proposed as an additional hepatokine involved in NASH development and insulin resistance. Protease Activated Receptor
Externí odkaz:
https://doaj.org/article/945f4fb8656c43e38474dd471095687a
Autor:
Santina Quarta, Michele Sandre, Mariagrazia Ruvoletto, Marta Campagnolo, Aron Emmi, Alessandra Biasiolo, Patrizia Pontisso, Angelo Antonini
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1623 (2024)
In Parkinson’s disease, neuroinflammation is a double-edged sword; when inflammation occurs it can have harmful effects, despite its important role in battling infections and healing tissue. Once triggered by microglia, astrocytes acquire a reactiv
Externí odkaz:
https://doaj.org/article/095e4faa993844efbbe2abc13eab8cd7
Autor:
Monica Chinellato, Matteo Gasparotto, Santina Quarta, Mariagrazia Ruvoletto, Alessandra Biasiolo, Francesco Filippini, Luca Spiezia, Laura Cendron, Patrizia Pontisso
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1486 (2023)
In the last decades, studies on the inflammatory signaling pathways in multiple pathological contexts have revealed new targets for novel therapies. Among the family of G-protein-coupled Proteases Activated Receptors, PAR2 was identified as a driver
Externí odkaz:
https://doaj.org/article/9292cdb2792e48cdbb95309ec57ce2d8
Autor:
Cristian Turato, Mariapia Vairetti, Marta Cagna, Alessandra Biasiolo, Andrea Ferrigno, Santina Quarta, Mariagrazia Ruvoletto, Silvia De Siervi, Patrizia Pontisso, Laura Giuseppina Di Pasqua
Publikováno v:
European Journal of Histochemistry, Vol 66, Iss 4 (2022)
We have investigated the change in SerpinB3 during hepatic ischemia and the potential role of its antiprotease activity in cell protection by the administration of wild-type SerpinB3 (SerpinB3-WT) or active loop-deleted recombinant SerpinB3 protein (
Externí odkaz:
https://doaj.org/article/132dd393be9445019719bfe2e49b6ede
Autor:
Erica Novo, Andrea Cappon, Gianmarco Villano, Santina Quarta, Stefania Cannito, Claudia Bocca, Cristian Turato, Maria Guido, Marina Maggiora, Francesca Protopapa, Salvatore Sutti, Alessia Provera, Mariagrazia Ruvoletto, Alessandra Biasiolo, Beatrice Foglia, Emanuele Albano, Patrizia Pontisso, Maurizio Parola
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease worldwide. In 20-30% of patients, NAFLD can progress into non-alcoholic steatohepatitis (NASH), eventually leading to fibrosis, cirrhosis and hepatocellular c
Externí odkaz:
https://doaj.org/article/0b2f8a9cdce347ea8e3573b42a3dc766
Autor:
Santina Quarta, Andrea Cappon, Cristian Turato, Mariagrazia Ruvoletto, Stefania Cannito, Gianmarco Villano, Alessandra Biasiolo, Maristella Maggi, Francesca Protopapa, Loris Bertazza, Silvano Fasolato, Maurizio Parola, Patrizia Pontisso
Publikováno v:
Biology, Vol 12, Iss 6, p 771 (2023)
Abnormal activation of the Wnt-β-catenin signaling cascade is involved in tumor growth and dissemination. SerpinB3 has been shown to induce β-catenin, and both molecules are overexpressed in tumors, particularly in those with poor prognoses. The ai
Externí odkaz:
https://doaj.org/article/7b0a7c7106054584aa5d18b622756d12
Autor:
Alessandra Biasiolo, Michele Sandre, Stefania Ferro, Santina Quarta, Mariagrazia Ruvoletto, Gianmarco Villano, Cristian Turato, Maria Guido, Oriano Marin, Patrizia Pontisso
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 739 (2023)
SerpinB3 is a serine protease inhibitor that plays a relevant role in disease progression and cancer by increasing fibrosis, cell proliferation, and invasion, besides conferring resistance to apoptosis. The mechanisms underlying these biological acti
Externí odkaz:
https://doaj.org/article/520129d75eae49a8b20590b0373d1ce4
Autor:
Mattia Albiero, Alice Fullin, Gianmarco Villano, Alessandra Biasiolo, Santina Quarta, Simone Bernardotto, Cristian Turato, Mariagrazia Ruvoletto, Gian Paolo Fadini, Patrizia Pontisso, Margherita Morpurgo
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1944 (2022)
Foot ulcerations are a disabling complication of diabetes and no treatment is currently available based on disease mechanisms. The protein serpin B3 (SB3) was identified as a positive biomarker of successful diabetic wound healing; therefore, its exo
Externí odkaz:
https://doaj.org/article/977cc502ad384eb2ba3d79a2201780d9
Autor:
Anna Maria Tolomeo, Santina Quarta, Alessandra Biasiolo, Mariagrazia Ruvoletto, Michela Pozzobon, Giada De Lazzari, Ricardo Malvicini, Cristian Turato, Giorgio Arrigoni, Patrizia Pontisso, Maurizio Muraca
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 703 (2021)
Extracellular vesicles (EVs) are increasingly studied as vectors for drug delivery because they can transfer a variety of molecules across biological barriers. SerpinB3 is a serine protease inhibitor that has shown a protective anti-apoptotic functio
Externí odkaz:
https://doaj.org/article/7e84797b475a443e8b4f24d7cedbd8e0
Autor:
Erica Novo, Gianmarco Villano, Cristian Turato, Stefania Cannito, Claudia Paternostro, Chiara Busletta, Alessandra Biasiolo, Santina Quarta, Elisabetta Morello, Claudia Bocca, Antonella Miglietta, Ezio David, Salvatore Sutti, Mario Plebani, Emanuele Albano, Maurizio Parola, Patrizia Pontisso
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract SerpinB3 is a hypoxia- and hypoxia-inducible factor-2α-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patient
Externí odkaz:
https://doaj.org/article/c74e478e1eb44cac816dd0dfb0e444b3