PARP Inhibitors in Brain Metastases from Epithelial Ovarian Cancer through a Multimodal Patient Journey: Case Reports and Literature Review

Autor: Simona Frezzini, Giulia Tasca, Lucia Borgato, Lucia Sartor, Annamaria Ferrero, Grazia Artioli, Alessandra Modena, Alessandra Baldoni

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 14, p 7887 (2024)

Epithelial ovarian cancer (EOC) is the deadliest gynecological malignancy worldwide. Brain metastasis (BM) is quite an uncommon presentation. However, the likelihood of central nervous system (CNS) metastasization should be considered in the context

Externí odkaz: https://doaj.org/article/f09c8d82f2d3492db1564552a9092b72

Oxaliplatin prior to PARP inhibitor in BRCA-mutated ovarian cancer

Autor: Maria Ornella Nicoletto, Alessandra Baldoni, Francesco Cavallin, Andrea Grego, Cristina Falci, Margherita Nardin, Enzo Mammano, Eleonora Lai, Valter Torri

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 15 (2023)

Background: The use of PARP inhibitor (PARPi) has shown a considerable benefit in progression-free survival (PFS) in relapsed, platinum-sensitive epithelial ovarian cancer (OC). Objective: Our study aimed to investigate the impact of the last platinu

Externí odkaz: https://doaj.org/article/9ed58ccb93c04822ab98dc828d26e551

Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21)

Autor: Andrés Poveda, Anne Floquet, Jonathan A Ledermann, Rebecca Asher, Richard T Penson, Amit M Oza, Jacob Korach, Tomasz Huzarski, Sandro Pignata, Michael Friedlander, Alessandra Baldoni, Tjoung-Won Park-Simon, Kenji Tamura, Gabe S Sonke, Alla Lisyanskaya, Jae-Hoon Kim, Elias Abdo Filho, Tsveta Milenkova, Elizabeth S Lowe, Phil Rowe, Ignace Vergote, Eric Pujade-Lauraine, Tomasz Byrski, Patricia Pautier, Philipp Harter, Nicoletta Colombo, Giovanni Scambia, Maria Nicoletto, Fiona Nussey, Andrew Clamp, Richard Penson, Amit Oza, Andrés Poveda Velasco, Manuel Rodrigues, Jean-Pierre Lotz, Frédéric Selle, Isabelle Ray-Coquard, Diane Provencher, Aleix Prat Aparicio, Laura Vidal Boixader, Clare Scott, Mayu Yunokawa, Jacques Medioni, Nicolas Pécuchet, Coraline Dubot, Thibault De La Motte Rouge, Marie-Christine Kaminsky, Béatrice Weber, Alain Lortholary, Christine Parkinson, Jonathan Ledermann, Sarah Williams, Susana Banerjee, Jonathan Cosin, James Hoffman, Marie Plante, Allan Covens, Gabe Sonke, Florence Joly, Holger Hirte, Amnon Amit, Koji Matsumoto, Sergei Tjulandin, Jae Hoon Kim, Laurence Gladieff, Roberto Sabbatini, David O'Malley, Patrick Timmins, Daniel Kredentser, Nuria Laínez Milagro, Maria Pilar Barretina Ginesta, Ariadna Tibau Martorell, Alfonso Gómez De Liaño Lista, Belén Ojeda González, Linda Mileshkin, Masaki Mandai, Ingrid Boere, Petronella Ottevanger, Joo-Hyun Nam, Elias Filho, Salima Hamizi, Francesco Cognetti, David Warshal, Elizabeth Dickson-Michelson, Scott Kamelle, Nathalie McKenzie, Gustavo Rodriguez, Deborah Armstrong, Eva Chalas, Paul Celano, Kian Behbakht, Susan Davidson, Stephen Welch, Limor Helpman, Ami Fishman, Ilan Bruchim, Magdalena Sikorska, Anna Słowińska, Wojciech Rogowski, Mariusz Bidziński, Beata Śpiewankiewicz, Antonio Casado Herraez, César Mendiola Fernández, Martina Gropp-Meier, Toshiaki Saito, Kazuhiro Takehara, Takayuki Enomoto, Hidemichi Watari, Chel Hun Choi, Byoung-Gie Kim, Jae Weon Kim, Roberto Hegg

Publikováno v: Lancet Oncology, 22, 5, pp. 620-631
Lancet Oncology, 22, 620-631
The Lancet Oncology, 22(5), 620-631. Lancet Publishing Group

Contains fulltext : 241226.pdf (Publisher’s version ) (Closed access) BACKGROUND: Olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, has previously been shown to extend progression-free survival versus placebo when given to patients with re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327550b0b53fe7a798b4b4246c0e4f41
https://doi.org/10.1016/s1470-2045(21)00073-5

Mutational and Immunophenotypic Profiling of a Series of 8 Tubo-ovarian Carcinosarcomas Revealed a Monoclonal Origin of the Disease

Autor: Luisa Santoro, Giada Munari, Giovanni Battista Nardelli, Massimo Rugge, Alessandra Baldoni, Luca Dal Santo, Cristiano Lanza, Valentina Carraro, Matteo Fassan, Ornella Nicoletto, Sara Pizzi, Silvia Chiarelli, Mariangela Trento, Carlo Saccardi, Roberta Salmaso

Publikováno v: International Journal of Gynecological Pathology. 39:305-312

Carcinosarcomas are rare, highly aggressive neoplasms composed of a combination of carcinomatous and sarcomatous elements. These tumors represent a paradigmatic field for the study of intratumor heterogeneity. A series of 8 tubo-ovarian carcinosarcom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec98075fec8a14ea223dc8472ed51ed8
https://doi.org/10.1097/pgp.0000000000000645

Resistance to glucose starvation as metabolic trait of platinum-resistant human epithelial ovarian cancer cells

Autor: Gian Luca De Salvo, Angela De Paoli, Anna Pagotto, Chiara Bellio, Anna Pastò, Francesca Ricci, Giovanna Damia, Alberto Amadori, Giorgia Pilotto, Alessandra Baldoni, Stefano Indraccolo, Maria Ornella Nicoletto

Publikováno v: Oncotarget

// Anna Pasto 1 , Anna Pagotto 1 , Giorgia Pilotto 1 , Angela De Paoli 2 , Gian Luca De Salvo 2 , Alessandra Baldoni 2 , Maria Ornella Nicoletto 2 , Francesca Ricci 3 , Giovanna Damia 3 , Chiara Bellio 1 , Stefano Indraccolo 2, * , Alberto Amadori 1,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979b3e62650221b94499805172044181
http://europepmc.org/articles/PMC5351643