Výsledky vyhledávání - "Alessa Pardo"

Novel PSCA targeting scFv-fusion proteins for diagnosis and immunotherapy of prostate cancer

Autor: Mehmet Kemal Tur, Stefan Barth, Alessa Pardo, Claudia Kessler, Rainer Fischer, Stefan Gattenlöhner, Katharina Kolberg

Publikováno v: Journal of Cancer Research and Clinical Oncology. 143:2025-2038

Despite great progress in the diagnosis and treatment of localized prostate cancer (PCa), there remains a need for new diagnostic markers that can accurately distinguish indolent and aggressive variants. One promising approach is the antibody-based t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe9c10125ad98fb824310f7e418123d
https://doi.org/10.1007/s00432-017-2472-9

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Targeting c-kit receptor in neuroblastomas and colorectal cancers using stem cell factor (SCF)-based recombinant bacterial toxins

Autor: Rama Shanker Verma, Janendra K. Batra, Stefan Barth, Reinhard Rosinke, Alessa Pardo, Swati Choudhary

Publikováno v: Applied Microbiology and Biotechnology. 100:263-277

Autocrine activation of c-kit (KIT receptor tyrosine kinase) has been postulated to be a potent oncogenic driver in small cell lung cancer, neuroblastoma (NB), and poorly differentiated colorectal carcinoma (CRC). Although targeted therapy involving

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7162f7b5ffdbb5ea866f44f0aebf09a7
https://doi.org/10.1007/s00253-015-6978-2

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Targeted killing of rhabdomyosarcoma cells by a MAP-based human cytolytic fusion protein

Autor: Hannes Brehm, Rainer Fischer, Stefan Barth, Dmitrij Hristodorov, Judith Niesen, Alessa Pardo, Radoslav Mladenov, Mehmet Kemal Tur

Publikováno v: Cancer Letters. 365:149-155

The treatment of rhabdomyosarcoma (RMS) is challenging, and the prognosis remains especially poor for high-grade RMS with metastasis. The conventional treatment of RMS is based on multi-agent chemotherapy combined with resection and radiotherapy, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7266614ba1b4604caaba9cd5bb428f06
https://doi.org/10.1016/j.canlet.2015.04.004

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Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo

Autor: Theophilus Thepen, Alessa Pardo, Stefan Barth, Radoslav Mladenov, Michael Huhn, Rainer Fischer, Dmitrij Hristodorov, Anh-Tuan Pham

Publikováno v: British Journal of Cancer

Background: Antibody drug conjugates (ADCs) and immunotoxins (ITs) are promising anticancer immunotherapeutics. Despite their encouraging performance in clinical trials, both ADCs and ITs often suffer from disadvantages such as stoichiometrically und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c53d3148b3803d501465a120b042edf
https://doi.org/10.1038/bjc.2013.457

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SNAP-Tag Technology: A General Introduction

Autor: Alessa Pardo, Jenny Fitting, Christiane Puettmann, Katharina Kolberg, Stefan Barth

Publikováno v: Current Pharmaceutical Design. 19:5406-5413

Over the past few years, the SNAP-tag technology has become a methodology with great potential in a variety of applications, e.g. the (specific) visualization of individual proteins and studies of protein interaction in living cells. Furthermore, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6f957e391c56685c3b42dad4076728
https://doi.org/10.2174/13816128113199990514

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Granzyme B-based cytolytic fusion protein targeting EpCAM specifically kills triple negative breast cancer cells in vitro and inhibits tumor growth in a subcutaneous mouse tumor model

Autor: Thomas Nachreiner, Fabian Kiessling, Alessa Pardo, Dmitrij Hristodorov, Anh-Tuan Pham, Theophilus Thepen, Manal Amoury, Wijnand Helfrich, Katharina Kolberg, Stefano Di Fiore, Stefan Barth, Ahmad Fawzi Hussain, Rainer Fischer, Radoslav Mladenov

Publikováno v: Cancer letters, 372(2), 201-209. ELSEVIER IRELAND LTD

Triple-negative breast cancer (TNBC) is associated with poor prognosis and high prevalence among young premenopausal women. Unlike in other breast cancer subtypes, no targeted therapy is currently available. Overexpression of epithelial cell adhesion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d6859673fec3065cf7cb6d0350d578
https://research.rug.nl/en/publications/2e9958d4-de01-40bb-b2af-2caf41a6a400

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In vivo imaging of immunotoxin treatment using Katushka-transfected A-431 cells in a murine xenograft tumour model

Autor: Rainer Fischer, Michael Stöcker, Alessa Pardo, Theo Thepen, Florian Kampmeier, Georg Melmer, Stefan Barth

Publikováno v: Cancer Immunology, Immunotherapy. 61:1617-1626

Preclinical in vivo analyses of treatment responses are an important prerequisite to evaluate new therapeutics. Molecular in vivo imaging in the far red (FR)/near infra red (NIR) is a promising method, as it enables measurements at different time poi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::734af11eb75d2134cc8a47f2e027840c
https://doi.org/10.1007/s00262-012-1219-3

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Eukaryotic expression and secretion of EGFP-labeled annexin A5

Autor: Chris P. M. Reutelingsperger, Rainer Fischer, Christian Hetzel, Alessa Pardo, Stefan Barth, Michael Stöcker

Publikováno v: Protein Expression and Purification. 58:325-331

The Ca2+-dependent binding of annexin A5 to phosphatidylserine on cell surfaces is a reliable marker for apoptosis that is widely used in flow cytometry based apoptosis assays. In this approach, annexin A5 must be coupled to a fluorescent dye, but st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452b13c609514983928d7a3475a34477
https://doi.org/10.1016/j.pep.2007.12.009

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