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1228 CHARACTERIZATION OF NOVEL, HIGHLY POTENT NS5A INHIBITORS WITH QD DOSING POTENTIAL AND ROBUST ACTIVITY IN AN HCV CHIMERIC ANIMAL MODEL

Autor: Nicholas, J.B., Buckman, B.O., Serebryany, V., Schaefer, C.J., Kossen, K., Ruhrmund, D., Hooi, L., Aleskovski, N., Arfsten, A., Lim, S.R., Pan, L., Huang, L., Rajagopalan, R., Misialek, S., Seiwert, S.

Publikováno v: Journal of Hepatology. Mar2011 Supplement 1, Vol. 54, pS485-S485. 1p.

Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.

Autor: Rajagopalan R; InterMune Incorporated, Brisbane, California, USA pt.ravi.r@gmail.com., Pan L; InterMune Incorporated, Brisbane, California, USA., Schaefer C; InterMune Incorporated, Brisbane, California, USA., Nicholas J; InterMune Incorporated, Brisbane, California, USA., Lim S; InterMune Incorporated, Brisbane, California, USA., Misialek S; InterMune Incorporated, Brisbane, California, USA., Stevens S; InterMune Incorporated, Brisbane, California, USA., Hooi L; InterMune Incorporated, Brisbane, California, USA., Aleskovski N; InterMune Incorporated, Brisbane, California, USA., Ruhrmund D; InterMune Incorporated, Brisbane, California, USA., Kossen K; InterMune Incorporated, Brisbane, California, USA., Huang L; InterMune Incorporated, Brisbane, California, USA., Yap S; InterMune Incorporated, Brisbane, California, USA., Beigelman L; InterMune Incorporated, Brisbane, California, USA., Serebryany V; InterMune Incorporated, Brisbane, California, USA., Liu J; InterMune Incorporated, Brisbane, California, USA., Sastry S; InterMune Incorporated, Brisbane, California, USA., Seiwert S; InterMune Incorporated, Brisbane, California, USA., Buckman B; InterMune Incorporated, Brisbane, California, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Dec 27; Vol. 61 (1). Date of Electronic Publication: 2016 Dec 27 (Print Publication: 2017).