Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Alesia Y. Trakhimets"'
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 164KB, Jurkat and 697 cell cultures were treated with UNC569 (500 nM) for 1 hour. Pervanadate was added to cell cultures for 3 minutes to stabilize the phosphorylated form of Mer. Cells were harvested after 24 and after 48 hours. Mer was immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b792aace27e76d7bcaa5f15a741f4e
https://doi.org/10.1158/1535-7163.22498869.v1
https://doi.org/10.1158/1535-7163.22498869.v1
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 172KB, Jurkat cell cultures were treated with the indicated concentrations of UNC569 for 1 hour. Pervanadate was added to cell cultures for 3 minutes to stabilize the phosphorylated form of Tyro3. Tyro3 was immunoprecipitated from cell lysates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fd6e6b0eb551d5ec5540b41a540d51
https://doi.org/10.1158/1535-7163.22498872.v1
https://doi.org/10.1158/1535-7163.22498872.v1
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 294KB, TAM receptor expression in Jurkat cell line was detected by western blot analysis. Whole cell lysates were prepared and phosphorylated (denoted by p-) and total proteins were detected. Western blots representative of three independent ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaa550c21b0e6ea25a3b97df14e5550
https://doi.org/10.1158/1535-7163.22498875
https://doi.org/10.1158/1535-7163.22498875
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 634KB, Eighteen fish (Myc1-Myc18) were treated with UNC569 for 2 weeks. Animals were imaged pre- and post-treatment, with GFP intensities quantified as described in the text. Ten of 18 fish (55.6%; Myc1-Myc8, Myc10, Myc16) showed >50% regressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff6aa50828c6ca22386951e59806f8d
https://doi.org/10.1158/1535-7163.22498863
https://doi.org/10.1158/1535-7163.22498863
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Gary L. Johnson, William P. Janzen, Emily A. Hull-Ryde, Jacqueline Norris-Drouin, Catherine Simpson, Dmitri Kireev, Chao Yang, Jing Liu, Christopher T. Cummings, Debra M. Hunter, Susan Sather, Alesia Y. Trakhimets, Lance A. Batchelor, J. Kimble Frazer, Jennifer Schlegel, Deborah DeRyckere, Sandra Christoph
PDF - 358KB, Cells were plated in methylcellulose in the presence of the indicated concentrations of UNC1653 or vehicle only. Colonies were counted after eight days. Long-term colony growth of Jurkat cells in methylcellulose is shown. Mean values and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d19ae5db09dd2cc4e5bb2320ddf698a
https://doi.org/10.1158/1535-7163.22498866
https://doi.org/10.1158/1535-7163.22498866
Autor:
Chao Yang, Gary L. Johnson, Sandra Christoph, Jing Liu, Susan Sather, William P. Janzen, Deborah DeRyckere, Xiaodong Wang, Debra Hunter, Jennifer Schlegel, Catherine Simpson, Jacqueline Norris-Drouin, H. Shelton Earp, Douglas K. Graham, Alesia Y. Trakhimets, Lance Batchelor, Christopher T. Cummings, Stephen V. Frye, Emily A. Hull-Ryde, Dmitri Kireev, J. Kimble Frazer
Publikováno v:
Molecular Cancer Therapeutics. 12:2367-2377
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Although survival rates have improved, patients with certain biologic subtypes still have suboptimal outcomes. Current chemotherapeutic regimens are associated with short-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f58befc22ef4d0b8ab4fad7c1cb77ea
https://doi.org/10.1158/1535-7163.mct-13-0040
https://doi.org/10.1158/1535-7163.mct-13-0040
Autor:
Sunil Sharma, William L. Heaton, J. Kimble Frazer, Anupam Verma, David Bearrs, Steven L. Warner, Alesia Y. Trakhimets, Jared Bearrs
Publikováno v:
Blood. 118:1519-1519
Abstract 1519 INTRODUCTION: Receptor tyrosine kinases AXL and MER belong to the TYRO3 kinase family, first identified as a transforming gene in chronic myeloid leukemia and are found at high levels in various cancers, including hematopoietic malignan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fa462669ea22a893b5c9d6340635af
https://doi.org/10.1182/blood.v118.21.1519.1519
https://doi.org/10.1182/blood.v118.21.1519.1519