Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alesia N. McKeown"'
Publikováno v:
eLife, Vol 4 (2015)
Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects
Externí odkaz:
https://doaj.org/article/5189ae9b95f047f5a8cd1a86ea03eebf
Autor:
Diane Miller Downhour, Nels C. Elde, Christina R. Necessary, Kristen A. Davenport, Lara Rheinemann, Alesia N. McKeown, Wesley I. Sundquist
Most restriction factors directly recognize specific virus features to execute antiviral functions. In contrast, we recently discovered an antiviral protein, retroCHMP3, that instead impairs the host endosomal complexes required for transport (ESCRT)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e40479334ecc03cfb18077df1e4615be
https://doi.org/10.1101/2021.04.27.441704
https://doi.org/10.1101/2021.04.27.441704
Autor:
Lara Rheinemann, Diane Miller Downhour, Kristen A. Davenport, Alesia N. McKeown, Wesley I. Sundquist, Nels C. Elde
Publikováno v:
Curr Biol
Most antiviral proteins recognize specific features of viruses. In contrast, the recently described antiviral factor retroCHMP3 interferes with the "host endosomal complexes required for transport" (ESCRT) pathway to inhibit the budding of enveloped
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3fc40bcea93c6f98a3fbda92692890
https://doi.org/10.1016/j.cub.2022.02.018
https://doi.org/10.1016/j.cub.2022.02.018
Autor:
Alesia N. McKeown, Kwa-Sur Tam, Nikollaq Vozhilla, Victor J. Torres, Nels C. Elde, Sang Yong Kim, Keenan A. Lacey, Christopher J. Day, Michael P. Jennings, Sergei B. Koralov, Kristina M. Boguslawski
Publikováno v:
Science Advances
Overcoming the species specificity of the MRSA toxin LukAB with a novel mouse model establishes a role for LukAB in vivo.
Many pathogens produce virulence factors that are specific toward their natural host. Clinically relevant methicillin-resis
Many pathogens produce virulence factors that are specific toward their natural host. Clinically relevant methicillin-resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3e9437e9b1353a3379be4855e29816
http://europepmc.org/articles/PMC7065885
http://europepmc.org/articles/PMC7065885
Autor:
Eric A. Ortlund, Dave W. Anderson, Joseph W. Thornton, Michael N. Murphy, Alesia N. McKeown, Jamie T. Bridgham
Publikováno v:
Cell. 159:58-68
SummaryComplex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a02dca1096b4565541f875c768a876
https://doi.org/10.1016/j.cell.2014.09.003
https://doi.org/10.1016/j.cell.2014.09.003
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Complexes of specifically interacting molecules, such as transcription factor proteins (TFs) and the DNA response elements (REs) they recognize, control most biological processes, but little is known concerning the functional and evolutionary effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7623cecd2f41be020d2f2976599bdd25
https://pubmed.ncbi.nlm.nih.gov/26076233
https://pubmed.ncbi.nlm.nih.gov/26076233
Publikováno v:
Biochemistry. 50(5)
We report a first test of the hypothesis that the mechanism of antimicrobial, cytolytic, and amphipathic cell-penetrating peptides in model membranes is determined by the thermodynamics of insertion of the peptide into the lipid bilayer from the surf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b337b606c16a4feaecf10ae0eb93a70
https://pubmed.ncbi.nlm.nih.gov/21166473
https://pubmed.ncbi.nlm.nih.gov/21166473
Publikováno v:
Biophysical Journal. 102:90a
We previously proposed three hypotheses relating the mechanism of antimicrobial and cytolytic peptides in model membranes to the Gibbs free energies of binding and insertion into the membrane [Almeida, P. F., and Pokorny, A. (2009) Biochemistry 48, 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de047f1a5be38167aef772e41ca93097
https://doi.org/10.1016/j.bpj.2011.11.512
https://doi.org/10.1016/j.bpj.2011.11.512