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Akademický článek

A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid.

Autor: Kalmode HP; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Ravikumar O; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Paymode DJ; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Bachert J; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Burns JM; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Stringham RW; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Aleshire SL; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States., Nelson RC; Medicines for All Institute, 737 N Fifth St., Box 980100, Richmond, Virginia 23298, United States.

Publikováno v: Organic process research & development [Org Process Res Dev] 2024 Mar 27; Vol. 28 (4), pp. 1195-1204. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).

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Akademický článek

Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183.

Autor: Khairnar PV; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Aleshire SL; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Kumar Ongolu R; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Jin L; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Laidlaw MG; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Donsbach KO; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Gupton BF; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Nelson RC; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States., Shanahan CS; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23219, United States.

Publikováno v: Organic process research & development [Org Process Res Dev] 2023 Dec 09; Vol. 28 (1), pp. 273-280. Date of Electronic Publication: 2023 Dec 09 (Print Publication: 2024).

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Akademický článek

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline.

Autor: Robey JMS; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Maity S; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Aleshire SL; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Ghosh A; R&D Centre, TCG Life Sciences Pvt. Limited, Kolkata, WB 700091, India., Yadaw AK; R&D Centre, TCG Life Sciences Pvt. Limited, Kolkata, WB 700091, India., Roy S; R&D Centre, TCG Life Sciences Pvt. Limited, Kolkata, WB 700091, India., Mear SJ; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Jamison TF; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States., Sirasani G; TCG GreenChem, Inc., Richmond, Virginia 23219, United States., Senanayake CH; TCG GreenChem, Inc., Richmond, Virginia 23219, United States., Stringham RW; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Gupton BF; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Donsbach KO; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Nelson RC; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States., Shanahan CS; Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States.

Publikováno v: Organic process research & development [Org Process Res Dev] 2023 Oct 13; Vol. 27 (11), pp. 2146-2159. Date of Electronic Publication: 2023 Oct 13 (Print Publication: 2023).

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Akademický článek

Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223.

Autor: Cardoso FSP; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Kadam AL; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Nelson RC; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Tomlin JW; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Dahal D; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States., Kuehner CS; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States., Gudvangen G; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States., Arduengo AJ 3rd; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States., Burns JM; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Aleshire SL; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Snead DR; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Qu F; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States., Belmore K; Department of Chemistry and Biochemistry, The University of Alabama, Tuscaloosa, Alabama 35487-0336, United States., Ahmad S; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States., Agrawal T; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States., Sieber JD; Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, Richmond, Virginia 23284-3208, United States., Donsbach KO; Medicines for All Institute, Virginia Commonwealth University, 737 N. 5th St., Box 980100, Richmond, Virginia 23298, United States.

Publikováno v: Organic process research & development [Org Process Res Dev] 2023 Jul 12; Vol. 27 (7), pp. 1390-1399. Date of Electronic Publication: 2023 Jul 12 (Print Publication: 2023).

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