Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alesha B. Castillo"'
Autor:
Lindsey H. Remark, Kevin Leclerc, Malissa Ramsukh, Ziyan Lin, Sooyeon Lee, Backialakshmi Dharmalingam, Lauren Gillinov, Vasudev V. Nayak, Paulo El Parente, Margaux Sambon, Pablo J. Atria, Mohamed A. E. Ali, Lukasz Witek, Alesha B. Castillo, Christopher Y, Park, Ralf H. Adams, Aristotelis Tsirigos, Sophie M. Morgani, Philipp Leucht
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts and more adipocytes leading to a loss of skeletal integrity. The molecular mechanisms that underlie this detrimental tra
Externí odkaz:
https://doaj.org/article/0d64cab140164afb8b8aaf26ab3db645
Autor:
Pablo J. Atria, Alesha B. Castillo
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Bones constantly change and adapt to physical stress throughout a person’s life. Mechanical signals are important regulators of bone remodeling and repair by activating skeletal stem and progenitor cells (SSPCs) to proliferate and differentiate int
Externí odkaz:
https://doaj.org/article/c4315d927791475d81caddde8fe156af
Publikováno v:
Journal of Clinical and Translational Science, Vol 2, Pp 35-35 (2018)
OBJECTIVES/SPECIFIC AIMS: Our goal is to assess age-related changes in osteogenic stem cell populations of bone tissue. We hypothesize that aging mice have reduced osteogenic capacity in response to physical stimulation due to aging-associated declin
Externí odkaz:
https://doaj.org/article/60eeca341e204ea0bcd3bde87db03df0
Autor:
Alexandra M Burr, Pamela Cabahug Zuckerman, Alesha B Castillo, Nicola C Partridge, Biju Parekkadan
Publikováno v:
Exp Biol Med (Maywood)
Delivering the parathyroid hormone (PTH) gene has been attempted preclinically in a handful of studies, but delivering full-length PTH (1–84) using adeno-associated viral (AAV) vectors has not. Given the difficulty in achieving therapeutic levels o
Autor:
Pamela Cabahug-Zuckerman, Chao Liu, Pablo Atria, Cinyee Cai, Emily Fang, Shahar Qureshi, Rikki Rooklin, Cesar Ponce, Camila Morocho, Alesha B. Castillo
Increased physical loading of the skeleton activates new bone formation ensuring its ability to meet mechanical demands over time; however, the capacity of bone to respond to mechanical stimulation diminishes with age. Osteocytes, the cells embedded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62bee843e4425014e932205f35156474
https://doi.org/10.1101/2022.08.25.505279
https://doi.org/10.1101/2022.08.25.505279
Autor:
Tareq Anani, Alesha B. Castillo
Publikováno v:
Bone. 154
Fracture healing is a complex, multistep process that is highly sensitive to mechanical signaling. To optimize repair, surgeons prescribe immediate weight-bearing as-tolerated within 24 hours after surgical fixation; however, this recommendation is b
Autor:
Bo Abrahamsen, Robert A. Adler, Sara Ajjour, Mohammad Mehdi Alemi, Dennis E. Anderson, Timothy R. Arnett, Mariam A. Assaad, Ghada T. Ballane, Roland Baron, J.H. Duncan Bassett, Douglas C. Bauer, William A. Bauman, Kristen M. Beavers, Sarah D. Berry, John P. Bilezikian, Emmanuel Biver, Dana Bliuc, Lynda F. Bonewald, Adele L. Boskey, Mary L. Bouxsein, Nathalie Bravenboer, Todd T. Brown, Susan V. Bukata, Katelyn Burkhart, Ernesto Canalis, Christopher Cardozo, Alesha B. Castillo, Jane A. Cauley, Jacqueline R. Center, Julia C. Chen, Roberto Civitelli, Adi Cohen, Felicia Cosman, Carolyn J. Crandall, Brooke M. Crawford, Natalie E. Cusano, Francisco J.A. de Paula, Kim Delbaere, David W. Dempster, Dima L. Diab, Ingrid Dick-de-Paula, Linda A. DiMeglio, Matthew T. Drake, Alanna M.K. Dubrovsky, Luca D’Onofrio, Richard Eastell, Grahame J. Elder, Ghada A. El-Hajj Fuleihan, Kristine E. Ensrud, Serge Ferrari, Bernard Freudenthal, Harry K. Genant, Louis C. Gerstenfeld, Lora Giangregorio, Evelien Gielen, Deborah T. Gold, Steven R. Goldring, Catherine M. Gordon, Francesca Gori, Gail A. Greendale, James F. Griffith, Peyman Hadji, Christopher J. Hernandez, Jonathan Hoggatt, Denise K. Houston, Amira I. Hussein, Christopher R. Jacobs, Xuezhi Jiang, James D. Johnston, Risa Kagan, Lamya Karim, Carrie Karvonen-Gutierrez, Wendy B. Katzman, Masanobu Kawai, Sundeep Khosla, Douglas P. Kiel, Saija A. Kontulainen, Paul Kostenuik, Alexandra Krez, Henry Kronenberg, Rajiv Kumar, Nancy E. Lane, Lisa Langsetmo, Michaël R. Laurent, L. Lawenius, Sergey Leikin, William D. Leslie, E. Michael Lewiecki, Minghao Liu, Yi Liu, Stephen R. Lord, Joseph Lorenzo, Nina S. Ma, Naim M. Maalouf, Robert Marcus, Michael R. McClung, Marcela Moraes Mendes, Paul D. Miller, Madhusmita Misra, Mahshid Mohseni, Elise F. Morgan, Suzanne N. Morin, Mona Al Mukaddam, Chris J.J. Mulder, Nandini Nair, Nicola Napoli, Nat Nasomyont, Dorothy A. Nelson, Jeri W. Nieves, Robert Nissenson, Claes Ohlsson, Christina V. Oleson, Laura Ortinau, Eric Orwoll, Susan M. Ott, Roberto Pacifici, Andrea Palermo, A.M. Parfitt, Dongsu Park, Sylvain Provot, Sonia Bhandari Randhawa, John F. Randolph, Fernando Rivadeneira, Pamela Gehron Robey, Lauren Robinson, Tara Rogers-Soeder, G. David Roodman, Clifford J. Rosen, Kenneth G. Saag, Shivani Sahni, Khashayar Sakhaee, David T. Scadden, Anne L. Schafer, Ernestina Schipani, Monica C. Serra, Jay R. Shapiro, Catherine Sherrington, James M. Shikany, Shonni J. Silverberg, Andrea J. Singer, K. Sjögren, Peter J. Snyder, Emily M. Stein, Christine M. Swanson, Pawel Szulc, Pamela Taxel, Peter J. Tebben, Sarah E. Twardowski, André G. Uitterlinden, Rachana Vaidya, Cristianna Vallera, Adriaan A. van Bodegraven, Bram C.J. van der Eerden, Marjolein C.H. van der Meulen, André J. van Wijnen, Dirk Vanderschueren, Jean Wactawski-Wende, Laura Watts, Nelson B. Watts, Ashley A. Weaver, Robert S. Weinstein, Graham R. Williams, Joy Wu, Karin C. Wu, Michael T. Yin, Elaine W. Yu, Hua Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cce6be4ef85b41d83683049082f9d16
https://doi.org/10.1016/b978-0-12-813073-5.00087-3
https://doi.org/10.1016/b978-0-12-813073-5.00087-3
Publikováno v:
Marcus and Feldman's Osteoporosis ISBN: 9780128130735
This chapter reviews the state of knowledge with respect to skeletal mechanobiology. Forms of tissue-level mechanical stimulation are first described, including electromagnetic fields, strain, fluid flow, vibration, and damage. The resulting biophysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7097aadac42d3608f74e095aa5125a3f
https://doi.org/10.1016/b978-0-12-813073-5.00014-9
https://doi.org/10.1016/b978-0-12-813073-5.00014-9
Mechanical signals are primary regulators of bone mass, architecture and repair, with load-induced changes in size and shape typically favoring a more mechanically competent structure. This article discusses the cells involved in bone mechanotransduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61767b8712f2c1053f9711971137950f
https://doi.org/10.1016/b978-0-12-801238-3.11209-7
https://doi.org/10.1016/b978-0-12-801238-3.11209-7
Autor:
Sara Temiyasathit, W Joyce Tang, Philipp Leucht, Charles T Anderson, Stefanie D Monica, Alesha B Castillo, Jill A Helms, Tim Stearns, Christopher R Jacobs
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33368 (2012)
Primary cilia, solitary microtubule-based structures that grow from the centriole and extend into the extracellular space, have increasingly been implicated as sensors of a variety of biochemical and biophysical signals. Mutations in primary cilium-r
Externí odkaz:
https://doaj.org/article/a3d3e702911849fa8a3700d20b871ce2