Nanocomposite treatment reduces disease and lethality in a murine model of acute graft-versus-host disease and preserves anti-tumor effects.

Autor: Priscila T T Bernardes, Bárbara M Rezende, Carolina B Resende, Talles P De Paula, Alesandra C Reis, William A Gonçalves, Elias G Vieira, Maurício V B Pinheiro, Danielle G Souza, Marina G M Castor, Mauro M Teixeira, Vanessa Pinho

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123004 (2015)

Graft versus host disease (GVHD) is an immunological disorder triggered by bone marrow transplantation that affects several organs, including the gastrointestinal tract and liver. Fullerenes and their soluble forms, fullerols, are nanocomposites with

Externí odkaz: https://doaj.org/article/cf3b79820cbc42fe841700d26e8eb3ae

ROCK Inhibition Drives Resolution of Acute Inflammation by Enhancing Neutrophil Apoptosis

Autor: Vivian Louise Soares de Oliveira, Lirlândia P. Sousa, Mauro M. Teixeira, Rayssa Maciel Athayde, Vanessa Pinho, Alesandra C. Reis, Denise A. Perez, Bárbara M. Rezende, Luisa Rezende, Izabela Galvão, William Antonio Gonçalves

Publikováno v: Cells, Vol 8, Iss 9, p 964 (2019)
Cells
Volume 8
Issue 9

Uncontrolled inflammation leads to tissue damage and it is central for the development of chronic inflammatory diseases and autoimmunity. An acute inflammatory response is finely regulated by the action of anti-inflammatory and pro-resolutive mediato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd32259773f1030439fc8e886e3b965a
https://www.mdpi.com/2073-4409/8/9/964

Author response for 'Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation'

Autor: Vanessa Pinho, Mauro M. Teixeira, Lirlândia P. Sousa, José Hugo de Sousa Gomes, Fernão Castro Braga, Denise A. Perez, Lucas S. Ribeiro, Izabela Galvão, Rayssa Maciel Athayde, Rodrigo Maia de Pádua, Alesandra C. Reis, Juliana P. Vago, Julia Dias da Silva, Bárbara M. Rezende

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d8a884dfe67a9f6a17f20ddc6f58c24
https://doi.org/10.1002/eji.201848049/v2/response1

Angiotensin-(1–7) Promotes Resolution of Eosinophilic Inflammation in an Experimental Model of Asthma

Autor: Maria da Glória Rodrigues-Machado, Aline C. Oliveira, Maria José Campagnole-Santos, Lívia Corrêa Barroso, Robson A.S. Santos, Mauro M. Teixeira, Vanessa Pinho, Daisy Motta-Santos, Denise A. Perez, Lucíola S. Barcelos, Alesandra C. Reis, Giselle Santos Magalhães, Juliana Fabiana Gregório

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology

Defective apoptosis of eosinophils, the main leukocyte in the pathogenesis of asthma, and delay in its removal lead to lung damage and loss of pulmonary function due to failure in the resolution of inflammation. Here we investigated the ability of an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5b44d5e3df303f7529106e704d8129
http://journal.frontiersin.org/article/10.3389/fimmu.2018.00058/full

Inhibition of 5-lipoxygenase alleviates graft-versus-host disease

Autor: Mauro M. Teixeira, Denise A. Perez, Carolina Braga de Resende, Marina G. M. Castor, William Antonio Gonçalves, Priscila T. T. Bernardes, Milene Alvarenga Rachid, Thiago M. Cunha, Fabiana S. Machado, Lisia Esper, Rayssa Maciel Athayde, Alesandra C. Reis, Bárbara M. Rezende, Vanessa Pinho

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Journal of Experimental Medicine

Rezende et al. report that the transplant of 5-lipoxygenase (5-LO)−deficient leukocytes protects mice from GVHD. Treatment with the 5-LO inhibitor zileuton or a LTB4 antagonist at the initial phase of the transplant achieves similar protective effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9888c4f5f9f89ff0765411f99d82fc81