Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ales Medek"'
Publikováno v:
Journal of pharmaceutical sciences. 110(4)
Physical or chemical interactions between drug product (DP) components can occur during manufacturing and/or upon storage; and may alter DP shelf life and performance. In this work a new Powder X-ray Diffraction (PXRD) peak was observed in DP under a
Publikováno v:
Molecular Pharmaceutics. 15:962-974
Methods were developed to systematically screen different polymer-surfactant combinations for the purpose of enhancing amorphous active pharmaceutical ingredient (API) solubility while maintaining its physical stability. Itraconazole (ITZ) was chosen
Autor:
Phillip W. Snyder, Praveen Mudunuri, Ales Medek, Santosh Kumar, Andrey Peresypkin, Wojciech Dworakowski, Song Bin, Philip Bransford, Edward G. Randles
Publikováno v:
Journal of pharmaceutical sciences. 108(2)
This article describes the discovery and characterization of nanocolloidal structures formed between VX-985 (an orally administered inhibitor of hepatitis C virus protease) and the bile salt, sodium taurocholate at concentrations of the latter >4 mM.
Autor:
Phillip W. Snyder, Jerry Tanoury, Ales Medek, Brian R. Mcclain, Steve Johnston, W. Patrick Walters, Dragutin Knezic, James P. Griffith, Patrick R. Connelly, Brian Patrick Quinn, Yuegang Zhang, Eleni Dokou, Philip Bransford
Publikováno v:
Biophysical Chemistry. 196:100-108
As compounds are optimized for greater potency during pharmaceutical discovery, their aqueous solubility often decreases, making them less viable as orally-administered drugs. To investigate whether potency and insolubility share a common origin, we
Publikováno v:
Journal of Pharmaceutical Sciences. 101:1475-1485
During milling, components are subjected to shear and tensile stresses, which can result in physical phase transformations. The purpose of the work described in this report is to understand the pathway by which two test compounds, d -salicin and γ-i
Publikováno v:
Journal of Pharmaceutical Sciences. 93:697-712
In this study, we have examined the acid–base characteristics of various citrate buffer systems alone and in the presence of the pH indicator dye, bromophenol blue, in aqueous solution, and after lyophilization to produce amorphous material. Fourie
Autor:
Ales Medek and, Lucio Frydman
Publikováno v:
Journal of the American Chemical Society. 122:684-691
Multinuclear solid-state nuclear magnetic resonance methods (59Co, 13C, 15N, and 31P NMR) were applied at natural abundance to the structural and dynamic analysis of cyanocobalamin (vitamin B12) polymorphs. These studies involved recrystallizing a se
Publikováno v:
Journal of Biomolecular NMR. 18:229-238
An approach is described for rapidly determining protein structures by NMR that utilizes proteins containing 13C-methyl labeled Val, Leu, and Ile (delta1) and protonated Phe and Tyr in a deuterated background. Using this strategy, the key NOEs that d
Autor:
Ales Medek, Lucio Frydman
Publikováno v:
Journal of Magnetic Resonance. 138:298-307
The present work discusses a new 2D NMR method for characterizing the principal values and relative orientations of the electric field gradient and the chemical shift tensors of half-integer quadrupolar sites. The technique exploits the different con
Publikováno v:
The Journal of Physical Chemistry A. 103:4830-4835
The acquisition of distortion-free solid-state nuclear magnetic resonance (NMR) powder line shapes from half-integer spin systems possessing large quadrupole couplings is exemplified on cobaltophthalocyanine complexes. The acquisition of ideal-like s