Výsledky vyhledávání - "Ales Machara"

Akademický článek

DSSBU: A novel mass spectrometry-cleavable analogue of the BS3 cross-linker

Autor: Swati, Banerjee, Jakub, Sýs, Aleš, Machara, Petra, Junková, Martin, Hubálek

Publikováno v: In Journal of Proteomics 6 January 2025 310

structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor

Autor: Jan Hodek, Jakub Hejdánek, Ales Machara, Jan Konvalinka, Milan Kožíšek, Jan Weber, Pavlína Řezáčová, Kateřina Radilová, Petr Pachl

Publikováno v: Antiviral research. 185

Influenza viruses can cause severe respiratory infections in humans, leading to nearly half a million deaths worldwide each year. Improved antiviral drugs are needed to address the threat of development of novel pandemic strains. Current therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76abffb793ac6b35b0880f59a029f9f3
https://pubmed.ncbi.nlm.nih.gov/33166574

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Identification and Enantiodivergent Synthesis of (5Z,9S)-Tetradec-5-en-9-olide, a Queen-Specific Volatile of the Termite Silvestritermes minutus

Autor: Klára Dolejšová, Jan Křivánek, Lucie Bednárová, Pavlína Kyjaková, Ales Machara, Robert Hanus, Jana Havlíčková, Pavel Majer

Publikováno v: Journal of Natural Products. 81:2266-2274

The queens of social insects differ from sterile colony members in many aspects of their physiology. Besides adaptations linked with their specialization for reproduction and extended lifespan, the queens also invest in the maintenance of their repro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9371b421fd97cd9bbef28123fc71352f
https://doi.org/10.1021/acs.jnatprod.8b00632

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Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1

Autor: Petr Pachl, Jana Pokorná, Ales Machara, Milan Kožíšek, Pavlína Řezáčová, Pavel Majer, Kateřina Rojíková, Václav Navrátil, Carlos Berenguer Albiñana, Jason Hudlicky, Jan Konvalinka, Václav Zima

Publikováno v: Bioorganicmedicinal chemistry. 27(13)

This study focuses on design, synthesis and in vitro evaluation of inhibitory potency of two series of sialylmimetic that target an exosite ("150-cavity") adjacent to the active site of influenza neuraminidases from A/California/07/2009 (H1N1) pandem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfddee6b55c0413d3e34bdcbcaeb476c
https://pubmed.ncbi.nlm.nih.gov/31128993

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Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

Autor: Miroslav Flieger, Jan Weber, Jan Konvalinka, Ales Machara, Jindřich Fanfrlík, Pavel Majer, Jiří Brynda, Jan Hodek, Milan Kožíšek, Kateřina Radilová, Elena Karlukova, Václav Zima, Carlos Berenguer Albiñana

Publikováno v: European Journal of Medicinal Chemistry. 208:112754

The biological effects of flavonoids on mammal cells are diverse, ranging from scavenging free radicals and anti-cancer activity to anti-influenza activity. Despite appreciable effort to understand the anti-influenza activity of flavonoids, there is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ec9f1e0b411567edc3c46fb3f07bce
https://doi.org/10.1016/j.ejmech.2020.112754

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Direct Synthesis of Noroxymorphone from Thebaine: Unusual CeIVOxidation of a Methoxydiene-Iron Complex to an Enone-γ-Nitrate

Autor: D. Phillip Cox, Mary Ann A. Endoma-Arias, Ivana Císařová, Tomas Hudlicky, Ales Machara

Publikováno v: European Journal of Organic Chemistry. 2016:1500-1503

Noroxymorphone was prepared from thebaine in seven operations. The key steps involved the successive N- and O-demethylations of an iron tricarbonyl complex of thebaine followed by the unusual ceric ammonium nitrate oxidation of the methoxydiene moiet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9e38545844f0707fea578450c587da8
https://doi.org/10.1002/ejoc.201600153

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A MODULAR SYNTHESIS OFN-BENZOTRIAZOLE UREAS USING ALKYLATION OF 5-NITROBENZOTRIAZOLE

Autor: Martin Kotora, Jan Konvalinka, Ales Machara

Publikováno v: ChemistrySelect. 1:101-107

N-Alkylations of monosubstituted benzotriazoles yield isomeric products with distinct topology, i. e. 1H- or to 2H-isomers. Therefore, the molecular shape of these compounds varies and this results in distinct biological and physical properties. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a7ba0076cf240a3da5031690ab2bf85
https://doi.org/10.1002/slct.201600025

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Reinvestigation of acetylation of 3,4-dihydroxybenzaldehyde and reconciliation of previously reported analytical data

Autor: Carlos Berenguer Albiñana, Tomas Hudlicky, Ales Machara, John J. Hayward

Publikováno v: Tetrahedron Letters. 57:1019-1021

Acetylation of 3,4-dihydroxybenzaldehyde was reinvestigated. The results in the regiochemical outcome were analyzed in detail by NMR methods and compared with previously published data.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6692979b63d0dd65ffa3406339e34141
https://doi.org/10.1016/j.tetlet.2016.01.075

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ChemInform Abstract: A Modular Synthesis of N-Benzotriazole Ureas Using Alkylation of 5-Nitrobenzotriazole

Autor: Martin Kotora, Jan Konvalinka, Ales Machara

Publikováno v: ChemInform. 47

Various alkyl-amino-benzotriazoles obtained by reduction of the corresponding nitro compounds are used as starting materials for the synthesis of urea derivatives.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60d60d2e2ea4a1e662c4fb9de43352c0
https://doi.org/10.1002/chin.201626113

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