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Akademický článek

Modulation of Gut Microbiome and Autism Symptoms of ASD Children Supplemented with Biological Response Modifier: A Randomized, Double-Blinded, Placebo-Controlled Pilot Study

Autor: Jela Hrnciarova, Klara Kubelkova, Vanda Bostik, Ivan Rychlik, Daniela Karasova, Vladimir Babak, Magdalena Datkova, Katerina Simackova, Ales Macela

Publikováno v: Nutrients, Vol 16, Iss 13, p 1988 (2024)

The etiology and mechanisms of autism and autism spectrum disorder (ASD) are not yet fully understood. There is currently no treatment for ASD for providing significant improvement in core symptoms. Recent studies suggest, however, that ASD is associ

Externí odkaz: https://doaj.org/article/23acb0cbbae645229d3cd81606a8a8a1

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Akademický článek

Innate Immune Recognition, Integrated Stress Response, Infection, and Tumorigenesis

Autor: Klara Kubelkova, Vanda Bostik, Lokesh Joshi, Ales Macela

Publikováno v: Biology, Vol 12, Iss 4, p 499 (2023)

Engagement of PRRs in recognition of PAMPs or DAMPs is one of the processes that initiates cellular stress. These sensors are involved in signaling pathways leading to induction of innate immune processes. Signaling initiated by PRRs is associated wi

Externí odkaz: https://doaj.org/article/ac9b175dc6164493beb174c72e5be7d8

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Akademický článek

Early infection-induced natural antibody response

Autor: Klara Kubelkova, Tomas Hudcovic, Hana Kozakova, Jaroslav Pejchal, Ales Macela

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract There remains to this day a great gap in understanding as to the role of B cells and their products—antibodies and cytokines—in mediating the protective response to Francisella tularensis, a Gram-negative coccobacillus belonging to the g

Externí odkaz: https://doaj.org/article/783d0f22cbe14f2ab15a2718817c36e4

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Akademický článek

Francisella and Antibodies

Autor: Klara Kubelkova, Ales Macela

Publikováno v: Microorganisms, Vol 9, Iss 10, p 2136 (2021)

Immune responses to intracellular pathogens depend largely upon the activation of T helper type 1-dependent mechanisms. The contribution of B cells to establishing protective immunity has long been underestimated. Francisella tularensis, including a

Externí odkaz: https://doaj.org/article/cac51d70d92241faae4477c2a6857262

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Akademický článek

Innate Immune Recognition: An Issue More Complex Than Expected

Autor: Klara Kubelkova, Ales Macela

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)

Primary interaction of an intracellular bacterium with its host cell is initiated by activation of multiple signaling pathways in response to bacterium recognition itself or as cellular responses to stress induced by the bacterium. The leading molecu

Externí odkaz: https://doaj.org/article/3bd9da3c1de94ddc8a7712107c30a9bc

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Akademický článek

Why Does SARS-CoV-2 Infection Induce Autoantibody Production?

Autor: Ales Macela, Klara Kubelkova

Publikováno v: Pathogens, Vol 10, Iss 3, p 380 (2021)

SARS-CoV-2 infection induces the production of autoantibodies, which is significantly associated with complications during hospitalization and a more severe prognosis in COVID-19 patients. Such a response of the patient’s immune system may reflect

Externí odkaz: https://doaj.org/article/3eff3a09e58b43b0b9dfa0d14c3fd6fa

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Akademický článek

Innate Immune Recognition: Implications for the Interaction of Francisella tularensis with the Host Immune System

Autor: Zuzana Krocova, Ales Macela, Klara Kubelkova

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)

The intracellular bacterial pathogen Francisella tularensis causes serious infectious disease in humans and animals. Moreover, F. tularensis, a highly infectious pathogen, poses a major concern for the public as a bacterium classified under Category

Externí odkaz: https://doaj.org/article/b55582e92bb6435a9dad02f0db7488c8

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Akademický článek

Entry of Francisella tularensis into Murine B Cells: The Role of B Cell Receptors and Complement Receptors.

Autor: Lenka Plzakova, Zuzana Krocova, Klara Kubelkova, Ales Macela

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132571 (2015)

Francisella tularensis, the etiological agent of tularemia, is an intracellular pathogen that dominantly infects and proliferates inside phagocytic cells but can be seen also in non-phagocytic cells, including B cells. Although protective immunity is

Externí odkaz: https://doaj.org/article/4996b99a86d140799d963d92ca066d4f

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