Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ales Drobek"'
Autor:
Andrea Ujevic, Daniela Knizkova, Alzbeta Synackova, Michaela Pribikova, Tijana Trivic, Anna Dalinskaya, Ales Drobek, Veronika Niederlova, Darina Paprckova, Roldan De Guia, Petr Kasparek, Jan Prochazka, Juraj Labaj, Olha Fedosieieva, Bernhard Florian Roeck, Ondrej Mihola, Zdenek Trachtulec, Radislav Sedlacek, Ondrej Stepanek, Peter Draber
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by regulating the activation of TBK1 kinase. Mice lacking either TANK
Externí odkaz:
https://doaj.org/article/9b7940ea388e4264884e77c454cce6f0
Autor:
Haobo Zhang, Léa Bernaleau, Maeva Delacrétaz, Ed Hasanovic, Ales Drobek, Hermann Eibel, Manuele Rebsamen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112916- (2023)
Summary: Endolysosomal Toll-like receptors (TLRs) play crucial roles in immune responses to pathogens, while aberrant activation of these pathways is associated with autoimmune diseases, including systemic lupus erythematosus (SLE). The endolysosomal
Externí odkaz:
https://doaj.org/article/6e5cfdfc81ad45c69d7f5c47d7b8e156
Autor:
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Publikováno v:
eLife, Vol 12 (2023)
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we identified that Tregs increase the quo
Externí odkaz:
https://doaj.org/article/1259c927d0e9455aaea1c7377dffc5bd
Autor:
Darina Paprckova, Veronika Niederlova, Alena Moudra, Ales Drobek, Michaela Pribikova, Sarka Janusova, Kilian Schober, Ales Neuwirth, Juraj Michalik, Martina Huranova, Veronika Horkova, Michaela Cesnekova, Michaela Simova, Jan Prochazka, Jana Balounova, Dirk H. Busch, Radislav Sedlacek, Martin Schwarzer, Ondrej Stepanek
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mature T cells are selected for recognizing self-antigens with low to intermediate affinity in the thymus. Recently, the relative differences in self-reactivity among individual T-cell clones were appreciated as important factors regulating their fat
Externí odkaz:
https://doaj.org/article/3d221b08845a4bd9b620763e054dec64
Autor:
Veronika Horkova, Ales Drobek, Daniel Mueller, Celine Gubser, Veronika Niederlova, Lena Wyss, Carolyn G. King, Dietmar Zehn, Ondrej Stepanek
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1504-1514.e7 (2020)
Summary: Overtly self-reactive T cells are removed during thymic selection. However, it has been recently established that T cell self-reactivity promotes protective immune responses. Apparently, the level of self-reactivity of mature T cells must be
Externí odkaz:
https://doaj.org/article/4442a1007c8244559d23d9147e2200f3
Autor:
Matous Hrdinka, Kritika Sudan, Sissy Just, Ales Drobek, Ondrej Stepanek, Dirk Schlüter, Dirk Reinhold, Bryen A Jordan, Patricia Gintschel, Burkhart Schraven, Michael R Kreutz
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162863 (2016)
Transmembrane adaptor proteins (TRAPs) are important organisers for the transduction of immunoreceptor-mediated signals. Prr7 is a TRAP that regulates T cell receptor (TCR) signalling and potently induces cell death when overexpressed in human Jurkat
Externí odkaz:
https://doaj.org/article/bbb679c5e2df474abed259812b0a0946
Autor:
Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek
Publikováno v:
Nature Immunology. 24:174-185
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e5771858f2dd70484f422099c8b4e
https://doi.org/10.1038/s41590-022-01366-0
https://doi.org/10.1038/s41590-022-01366-0
Autor:
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2857041c2c03a18ec255c7325fd3a87
https://doi.org/10.7554/elife.79342.sa2
https://doi.org/10.7554/elife.79342.sa2
Autor:
Tomas Brdicka, Orest V. Matveichuk, Majd B. Protty, Vladimir Korinek, Jana Pokorná, Ales Drobek, Veronika Kanderova, Nataliia Pavliuchenko, Simon Borna, Matej Fabisik, Daniela Glatzová, Michael G. Tomlinson, Katarzyna Kwiatkowska, Iva Splichalova, Pavla Angelisova, Julia Starkova, Jarmila Králová, Petr Stanek, Meritxell Alberich-Jorda, Tereza Skopcova
Publikováno v:
Journal of Cellular and Molecular Medicine
WW domain binding protein 1‐like (WBP1L), also known as outcome predictor of acute leukaemia 1 (OPAL1), is a transmembrane adaptor protein, expression of which correlates with ETV6‐RUNX1 (t(12;21)(p13;q22)) translocation and favourable prognosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ca4208dff1914e4fc5043fb2cc9d7d
http://europepmc.org/articles/PMC6991692
http://europepmc.org/articles/PMC6991692
Autor:
Ales Drobek, Juraj Michalik, Helene Rossez, Iva Malatova, Ondrej Stepanek, Marek Kovar, Hana Vecerova, Veronika Niederlova, Sarka Janusova, Virginie Galati, Jirina Kovarova, Oksana Tsyklauri, Tereza Chadimova
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anti-cancer immunity. In this study, we identified that Tregs increase the qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599aeca3e9b07d430f109c214a4a66f9
https://doi.org/10.1101/2021.11.10.467495
https://doi.org/10.1101/2021.11.10.467495