Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alenka Lovy"'
Autor:
Ulises Ahumada-Castro, Galdo Bustos, Eduardo Silva-Pavez, Andrea Puebla-Huerta, Alenka Lovy, César Cárdenas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
In the last few years, metabolism has been shown to be controlled by cross-organelle communication. The relationship between the endoplasmic reticulum and mitochondria/lysosomes is the most studied; here, inositol 1,4,5-triphosphate (IP3) receptor (I
Externí odkaz:
https://doaj.org/article/b70527f940a24b41b11e74605904d11d
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phos
Externí odkaz:
https://doaj.org/article/b67169bc7cc04f7f849a894ad6e05bc4
Autor:
Alenka Lovy, Ulises Ahumada-Castro, Galdo Bustos, Paula Farias, Christian Gonzalez-Billault, Jordi Molgó, Cesar Cardenas
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mitochondria are highly dynamic organelles constantly undergoing fusion and fission. Ca2+ regulates many aspects of mitochondrial physiology by modulating the activity of several mitochondrial proteins. We previously showed that inhibition of constit
Externí odkaz:
https://doaj.org/article/568b3b200b074c67af61273d92420285
Autor:
Pablo Cruz, Ulises Ahumada-Castro, Galdo Bustos, Jordi Molgó, Daniela Sauma, Alenka Lovy, César Cárdenas
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 651 (2021)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an i
Externí odkaz:
https://doaj.org/article/d888ea1ab06f4bc7b9bd6464eaa09fd9
Autor:
César Cárdenas, Marioly Müller, Andrew McNeal, Alenka Lovy, Fabian Jaňa, Galdo Bustos, Felix Urra, Natalia Smith, Jordi Molgó, J. Alan Diehl, Todd W. Ridky, J. Kevin Foskett
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2313-2324 (2016)
In the absence of low-level ER-to-mitochondrial Ca2+ transfer, ATP levels fall, and AMPK-dependent, mTOR-independent autophagy is induced as an essential survival mechanism in many cell types. Here, we demonstrate that tumorigenic cancer cell lines,
Externí odkaz:
https://doaj.org/article/89987c5281d74189a1019aec52f6b6f5
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient availability, which is sustained by a metabolic reprograming now recognized as a hallmark of cancer. Warburg was the first to establish the relationship betwee
Externí odkaz:
https://doaj.org/article/f7c1399b9a0f4f8bb17e538909428c92
Publikováno v:
Frontiers in Oncology, Vol 7 (2017)
Recent evidence highlights that the cancer cell energy requirements vary greatly from normal cells and that cancer cells exhibit different metabolic phenotypes with variable participation of both glycolysis and oxidative phosphorylation. NADH–ubiqu
Externí odkaz:
https://doaj.org/article/7656124c30a94342abe68f21bc66a9ee
Autor:
Paula Farias, Armen Zakarian, Jordi Molgó, Artur K. Mailyan, Maša Podunavac, Jeffrey J. Jackson, Cesar Cardenas, Hernan Huerta, Alenka Lovy
Publikováno v:
Angewandte Chemie (International ed. in English), vol 60, iss 20
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2021, 60 (20), pp.11278-11282. ⟨10.1002/anie.202102259⟩
Angew Chem Int Ed Engl
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2021, 60 (20), pp.11278-11282. ⟨10.1002/anie.202102259⟩
Angew Chem Int Ed Engl
The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B is based on the early application of Ireland-Claisen rearrangement, macrolactamization, and a late-stage installation of the oxaquinolizidine units by lacta
Autor:
Melany Rios, Fabián Jaña, José Rivas, Muniswamy Madesh, Galdo Bustos, Eduardo A. Sagredo, Alenka Lovy, Félix A. Urra, Zhiwei Dong, Pablo Cruz, Oscar Cerda, Carla Basualto-Alarcón, César Cárdenas
Publikováno v:
Mitochondrion. 49:73-82
Cytosolic calcium (cCa2+) entry into mitochondria is facilitated by the mitochondrial membrane potential (ΔΨm), an electrochemical gradient generated by the electron transport chain (ETC). Is has been assumed that as long as mutations that affect t
Autor:
Galdo, Bustos, Ulises, Ahumada-Castro, Eduardo, Silva-Pavez, Andrea, Puebla, Alenka, Lovy, J, Cesar Cardenas
Publikováno v:
International review of cell and molecular biology. 363
Cancer is a leading cause of death worldwide. All major tumor suppressors and oncogenes are now recognized to have fundamental connections with metabolic pathways. A hallmark feature of cancer cells is a reprogramming of their metabolism even when nu